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    Pdcd4 programmed cell death 4 [ Mus musculus (house mouse) ]

    Gene ID: 18569, updated on 8-Aug-2016
    Official Symbol
    Pdcd4provided by MGI
    Official Full Name
    programmed cell death 4provided by MGI
    Primary source
    MGI:MGI:107490
    See related
    Ensembl:ENSMUSG00000024975
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ma3; Tis; D19Ucla1
    Orthologs
    Location:
    19 D2; 19 48.73 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (53892231..53929861)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (53966721..54004351)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 20 Neighboring gene predicted gene 16299 Neighboring gene predicted gene, 41863 Neighboring gene predicted gene, 30990 Neighboring gene BBSome interacting protein 1 Neighboring gene soc-2 (suppressor of clear) homolog (C. elegans) Neighboring gene adrenergic receptor, alpha 2a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • PI3K/Akt/mTOR signaling pathway, organism-specific biosystem (from LIPID MAPS)
      PI3K/Akt/mTOR signaling pathway, organism-specific biosystem
      PI3K/Akt/mTOR signaling pathway
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell aging ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myofibroblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    programmed cell death protein 4
    Names
    protein MA-3
    topoisomerase-inhibitor suppressed protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168491.1NP_001161963.1  programmed cell death protein 4

      See identical proteins and their annotated locations for NP_001161963.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC117612
      Consensus CDS
      CCDS29903.1
      UniProtKB/Swiss-Prot
      Q61823
      Related
      ENSMUSP00000025931, ENSMUST00000025931
      Conserved Domains (1) summary
      smart00544
      Location:327440
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    2. NM_001168492.1NP_001161964.1  programmed cell death protein 4

      See identical proteins and their annotated locations for NP_001161964.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 3' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC117612, BC055739
      Consensus CDS
      CCDS29903.1
      UniProtKB/Swiss-Prot
      Q61823
      Related
      ENSMUSP00000133135, ENSMUST00000165617
      Conserved Domains (1) summary
      smart00544
      Location:327440
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    3. NM_011050.4NP_035180.2  programmed cell death protein 4

      See identical proteins and their annotated locations for NP_035180.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC117612, AK134366
      Consensus CDS
      CCDS29903.1
      UniProtKB/Swiss-Prot
      Q61823
      Related
      ENSMUSP00000073975, ENSMUST00000074371
      Conserved Domains (1) summary
      smart00544
      Location:327440
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      53892231..53929861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526762.3XP_006526825.1  

      See identical proteins and their annotated locations for XP_006526825.1

      UniProtKB/Swiss-Prot
      Q61823
      Conserved Domains (1) summary
      smart00544
      Location:327440
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins