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    COG3 component of oligomeric golgi complex 3 [ Homo sapiens (human) ]

    Gene ID: 83548, updated on 14-Apr-2016
    Official Symbol
    COG3provided by HGNC
    Official Full Name
    component of oligomeric golgi complex 3provided by HGNC
    Primary source
    HGNC:HGNC:18619
    See related
    Ensembl:ENSG00000136152 HPRD:08443; MIM:606975; Vega:OTTHUMG00000016855
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SEC34
    Summary
    This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result in multiple deficiencies in protein glycosylation. The protein encoded by this gene is involved in ER-Golgi transport.[provided by RefSeq, Jun 2011]
    Orthologs
    Location:
    13q14.13
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 13 NC_000013.11 (45464895..45536698)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (46039030..46110833)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 30 Neighboring gene SLC25A30 antisense RNA 1 Neighboring gene peptidylprolyl isomerase A pseudogene 25 Neighboring gene glutamate rich 6B Neighboring gene RNA, 5S ribosomal pseudogene 27 Neighboring gene TIMM9 pseudogene 3

    Replication interactions

    Interaction Pubs
    Knockdown of component of oligomeric golgi complex 3 (COG3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

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    • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
      Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
    • COPI-mediated anterograde transport, organism-specific biosystem (from REACTOME)
      COPI-mediated anterograde transport, organism-specific biosystemThe ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2...
    • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
      ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
      Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    ER to Golgi vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ER to Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
     
    Golgi organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intra-Golgi vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to organelle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retrograde transport, vesicle recycling within Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    retrograde vesicle-mediated transport, Golgi to ER IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    Golgi transport complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cis-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    trans-Golgi network membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    conserved oligomeric Golgi complex subunit 3
    Names
    COG complex subunit 3
    p94
    tethering factor SEC34
    vesicle-docking protein SEC34 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031431.3NP_113619.2  conserved oligomeric Golgi complex subunit 3

      See identical proteins and their annotated locations for NP_113619.2

      Status: REVIEWED

      Source sequence(s)
      AF332595, AF349676, BP396616, DC307455
      Consensus CDS
      CCDS9398.1
      UniProtKB/Swiss-Prot
      Q96JB2
      Related
      ENSP00000258654, OTTHUMP00000018352, ENST00000349995, OTTHUMT00000044777
      Conserved Domains (1) summary
      pfam04136
      Location:126282
      Sec34; Sec34-like family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p2 Primary Assembly

      Range
      45464895..45536698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011535267.1XP_011533569.1  

      Conserved Domains (1) summary
      pfam04136
      Location:126282
      Sec34; Sec34-like family
    2. XM_011535268.1XP_011533570.1  

      Related
      ENSP00000481332, OTTHUMP00000275154, ENST00000617493, OTTHUMT00000474891
      Conserved Domains (1) summary
      pfam04136
      Location:126282
      Sec34; Sec34-like family
    3. XM_011535266.1XP_011533568.1  

      See identical proteins and their annotated locations for XP_011533568.1

      Conserved Domains (1) summary
      pfam04136
      Location:158
      Sec34; Sec34-like family

    RNA

    1. XR_429222.2 RNA Sequence

    2. XR_245400.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018924.2 Alternate CHM1_1.1

      Range
      46007708..46079775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001204476.1: Suppressed sequence

      Description
      NM_001204476.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.