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    MARK2 MAP/microtubule affinity-regulating kinase 2 [ Homo sapiens (human) ]

    Gene ID: 2011, updated on 30-Jun-2015
    Official Symbol
    MARK2provided by HGNC
    Official Full Name
    MAP/microtubule affinity-regulating kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:3332
    See related
    Ensembl:ENSG00000072518; HPRD:02753; MIM:600526
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EMK1; EMK-1; PAR-1; Par1b; Par-1b
    Summary
    This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
    Orthologs
    See MARK2 in Epigenomics, MapViewer
    Location:
    11q13.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (63838928..63911020)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63606400..63678492)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 84 Neighboring gene atherin-like Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex, subunit g, pseudogene 1 Neighboring gene uncharacterized LOC105369336 Neighboring gene transfer RNA-Arg (CCT) 9-1 Neighboring gene REST corepressor 2 Neighboring gene N(alpha)-acetyltransferase 40, NatD catalytic subunit

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Clone Names

    • MGC99619

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    tau-protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    activation of protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    establishment of cell polarity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    establishment of cell polarity TAS
    Traceable Author Statement
    more info
    PubMed 
    establishment or maintenance of epithelial cell apical/basal polarity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion degradation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    mitochondrion localization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-threonine phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basal cortex IEA
    Inferred from Electronic Annotation
    more info
     
    lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule bundle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    serine/threonine-protein kinase MARK2
    Names
    ELKL motif kinase 1
    MARK2
    PAR1 homolog b
    Ser/Thr protein kinase PAR-1B
    serine/threonine protein kinase EMK
    NP_001034558.2
    NP_001156768.1
    NP_001156769.1
    NP_004945.4
    NP_059672.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029771.1 RefSeqGene

      Range
      5001..77093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001039469.2NP_001034558.2  serine/threonine-protein kinase MARK2 isoform d

      See identical proteins and their annotated locations for NP_001034558.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
      Source sequence(s)
      AB188493, AK225766, AP003780, BC008771, BM719402
      Consensus CDS
      CCDS53649.1
      UniProtKB/Swiss-Prot
      Q7KZI7
      Related
      ENSP00000385751, ENST00000402010
      Conserved Domains (4) summary
      cd12201
      Location:689787
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:53304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:322363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    2. NM_001163296.1NP_001156768.1  serine/threonine-protein kinase MARK2 isoform e

      See identical proteins and their annotated locations for NP_001156768.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame exons in the 3' coding region, compared to variant 4. The resulting isoform (e) lacks two internal segments, compared to isoform d.
      Source sequence(s)
      AB188493, AK225766, AP003780, BM719402
      Consensus CDS
      CCDS53650.1
      UniProtKB/Swiss-Prot
      Q7KZI7
      Conserved Domains (4) summary
      cd12201
      Location:620718
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:53304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:322363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    3. NM_001163297.1NP_001156769.1  serine/threonine-protein kinase MARK2 isoform f

      See identical proteins and their annotated locations for NP_001156769.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks three alternate in-frame exons and uses an alternate in-frame splice site, compared to variant 4. The resulting isoform (f) lacks two internal segments and 1 internal residue, compared to isoform d.
      Source sequence(s)
      AB188493, AK225766, AP003780, BM719402
      Consensus CDS
      CCDS53651.1
      UniProtKB/Swiss-Prot
      Q7KZI7
      Conserved Domains (4) summary
      cd12201
      Location:610708
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:53304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:322363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    4. NM_004954.4NP_004945.4  serine/threonine-protein kinase MARK2 isoform c

      See identical proteins and their annotated locations for NP_004945.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region and uses an alternate in-frame splice site in the central coding region, compared to variant 4. The resulting isoform (c) lacks two internal segments and 1 internal residue, compared to isoform d.
      Source sequence(s)
      AB188493, AK225766, AP003780, BC084540, BM719402
      Consensus CDS
      CCDS8051.2
      UniProtKB/Swiss-Prot
      Q7KZI7
      Related
      ENSP00000367041, ENST00000377810
      Conserved Domains (4) summary
      cd12201
      Location:625723
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:53304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:322363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    5. NM_017490.3NP_059672.2  serine/threonine-protein kinase MARK2 isoform a

      See identical proteins and their annotated locations for NP_059672.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, lacks an in-frame exon, and uses an alternate in-frame splice site, compared to variant 4. The resulting isoform (a) has a shorter N-terminus and lacks an internal segment and 1 internal residue, compared to isoform d.
      Source sequence(s)
      AK290339, AP003780, BM719402, BT007342, DA855402
      Consensus CDS
      CCDS41665.1
      UniProtKB/TrEMBL
      A8K2S4
      UniProtKB/Swiss-Prot
      Q7KZI7
      Conserved Domains (4) summary
      cd12201
      Location:646744
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:20271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:289330
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:19271
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

      Range
      63838928..63911020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544789.1XP_011543091.1  

      Conserved Domains (4) summary
      cd12201
      Location:709807
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    2. XM_011544792.1XP_011543094.1  

      Conserved Domains (4) summary
      cd12201
      Location:694792
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    3. XM_011544790.1XP_011543092.1  

      Conserved Domains (4) summary
      cd12201
      Location:700798
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    4. XM_011544793.1XP_011543095.1  

      Conserved Domains (4) summary
      cd12201
      Location:685783
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    5. XM_011544797.1XP_011543099.1  

      Conserved Domains (4) summary
      cd12201
      Location:640738
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    6. XM_011544795.1XP_011543097.1  

      Conserved Domains (4) summary
      cd12201
      Location:646744
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    7. XM_011544791.1XP_011543093.1  

      Conserved Domains (4) summary
      cd12201
      Location:699797
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    8. XM_011544794.1XP_011543096.1  

      Conserved Domains (4) summary
      cd12201
      Location:654752
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    9. XM_011544796.1XP_011543098.1  

      Conserved Domains (4) summary
      cd12201
      Location:645743
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    10. XM_011544798.1XP_011543100.1  

      Conserved Domains (4) summary
      cd12201
      Location:630728
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    RNA

    1. XR_949802.1 RNA Sequence

    2. XR_949801.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      63489428..63561505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)