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    SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 [ Homo sapiens (human) ]

    Gene ID: 2542, updated on 3-Jan-2016
    Official Symbol
    SLC37A4provided by HGNC
    Official Full Name
    solute carrier family 37 (glucose-6-phosphate transporter), member 4provided by HGNC
    Primary source
    HGNC:HGNC:4061
    See related
    Ensembl:ENSG00000137700; HPRD:04052; MIM:602671
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G6PT1; G6PT2; G6PT3; GSD1b; GSD1c; GSD1d; TRG19; TRG-19; PRO0685
    Summary
    This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009]
    Orthologs
    See SLC37A4 in Epigenomics, MapViewer
    Location:
    11q23.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (119024351..119030906, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118895061..118901616, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 84 Neighboring gene ribosomal protein S25 Neighboring gene trafficking protein particle complex 4 Neighboring gene microRNA 3656 Neighboring gene hypoxia up-regulated 1 Neighboring gene VPS11, CORVET/HOPS core subunit

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Carbohydrate digestion and absorption, organism-specific biosystem (from KEGG)
      Carbohydrate digestion and absorption, organism-specific biosystemDietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates. These carbohydrates are digested t...
    • Carbohydrate digestion and absorption, conserved biosystem (from KEGG)
      Carbohydrate digestion and absorption, conserved biosystemDietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates. These carbohydrates are digested t...
    • Glucose transport, organism-specific biosystem (from REACTOME)
      Glucose transport, organism-specific biosystemCells take up glucose by facilitated diffusion, via glucose transporters (GLUTs) associated with the plasma membrane, a reversible reaction (Joost and Thorens 2001). Four tissue-specific GLUT isoform...
    • Hexose transport, organism-specific biosystem (from REACTOME)
      Hexose transport, organism-specific biosystemHexoses, notably fructose, glucose, and galactose, generated in the lumen of the small intestine by breakdown of dietary carbohydrate are taken up by enterocytes lining the microvilli of the small in...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
      Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
    • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
      SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC15729

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    glucose-6-phosphate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose-6-phosphate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transporter activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    carbohydrate metabolic process TAS
    Traceable Author Statement
    more info
     
    glucose homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    glucose transport TAS
    Traceable Author Statement
    more info
     
    glucose-6-phosphate transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose-6-phosphate transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hexose transport TAS
    Traceable Author Statement
    more info
     
    mitophagy in response to mitochondrial depolarization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    transmembrane transport TAS
    Traceable Author Statement
    more info
     
    transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    xenophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum NAS
    Non-traceable Author Statement
    more info
    PubMed 
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    integral component of endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    glucose-6-phosphate translocase
    Names
    glucose-5-phosphate transporter
    glucose-6-phosphatase, transport (glucose) protein 3
    glucose-6-phosphatase, transport (glucose-6-phosphate) protein 1
    glucose-6-phosphatase, transport (phosphate/pyrophosphate) protein 2
    microsomal glucose-6-phosphate transporter
    transformation-related gene 19 protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013331.1 RefSeqGene

      Range
      5001..11555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_187

    mRNA and Protein(s)

    1. NM_001164277.1NP_001157749.1  glucose-6-phosphate translocase isoform 1

      See identical proteins and their annotated locations for NP_001157749.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript variant. Variants 1, 4, and 5 encode the same protein (isoform 1).
      Source sequence(s)
      AK289642, AP003392, BC015650, BM506735, DC295438
      UniProtKB/TrEMBL
      A0A024R3H9
      UniProtKB/TrEMBL
      A8K0S7
      UniProtKB/Swiss-Prot
      O43826
      Related
      ENSP00000475241, ENST00000545985
      Conserved Domains (2) summary
      cd06174
      Location:14415
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00881
      Location:18397
      2A0104; phosphoglycerate transporter family protein
    2. NM_001164278.1NP_001157750.1  glucose-6-phosphate translocase isoform 2

      See identical proteins and their annotated locations for NP_001157750.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a longer protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK312628, AP003392, BC014663, BC064563, BM506735, DC295438
      UniProtKB/TrEMBL
      A0A024R3L1
      UniProtKB/Swiss-Prot
      O43826
      Related
      ENSP00000476176, ENST00000357590
      Conserved Domains (2) summary
      cd06174
      Location:14437
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00881
      Location:18419
      2A0104; phosphoglycerate transporter family protein
    3. NM_001164279.1NP_001157751.1  glucose-6-phosphate translocase isoform 3

      See identical proteins and their annotated locations for NP_001157751.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream translational start codon, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AK300646, BC064563, BM506735, DC295438
      UniProtKB/TrEMBL
      B4DUH2
      UniProtKB/Swiss-Prot
      O43826
      Related
      ENSP00000475991, ENST00000538950
      Conserved Domains (1) summary
      cd06174
      Location:4342
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    4. NM_001164280.1NP_001157752.1  glucose-6-phosphate translocase isoform 1

      See identical proteins and their annotated locations for NP_001157752.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 4, and 5 encode the same protein (isoform 1).
      Source sequence(s)
      BC002400, BC064563, BM506735
      UniProtKB/TrEMBL
      A0A024R3H9
      UniProtKB/Swiss-Prot
      O43826
      Conserved Domains (2) summary
      cd06174
      Location:14415
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00881
      Location:18397
      2A0104; phosphoglycerate transporter family protein
    5. NM_001467.5NP_001458.1  glucose-6-phosphate translocase isoform 1

      See identical proteins and their annotated locations for NP_001458.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 4, and 5 encode the same protein (isoform 1).
      Source sequence(s)
      BC014663, BM506735, DC295438
      UniProtKB/TrEMBL
      A0A024R3H9
      UniProtKB/Swiss-Prot
      O43826
      Related
      ENSP00000476242, ENST00000330775
      Conserved Domains (2) summary
      cd06174
      Location:14415
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00881
      Location:18397
      2A0104; phosphoglycerate transporter family protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

      Range
      119024351..119030906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p2 PATCHES

    Genomic

    1. NW_009646203.1 Reference GRCh38.p2 PATCHES

      Range
      45951..52505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      118781352..118787906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)