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AEBP1 AE binding protein 1 [ Homo sapiens (human) ]

Gene ID: 165, updated on 5-Apr-2015
Official Symbol
AEBP1provided by HGNC
Official Full Name
AE binding protein 1provided by HGNC
Primary source
HGNC:HGNC:303
See related
Ensembl:ENSG00000106624; HPRD:04281; MIM:602981; Vega:OTTHUMG00000023362
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACLP
Summary
This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013]
Orthologs
See AEBP1 in MapViewer
Location:
7p13
Exon count:
21
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (44104320..44114565)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44143960..44154164)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene microRNA 6838 Neighboring gene polymerase (DNA directed), mu Neighboring gene uncharacterized LOC102724964 Neighboring gene microRNA 4649 Neighboring gene polymerase (DNA directed), delta 2, accessory subunit Neighboring gene RNA, 5S ribosomal pseudogene 230

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ33612

Gene Ontology Provided by GOA

Process Evidence Code Pubs
muscle organ development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
adipocyte enhancer-binding protein 1
Names
adipocyte enhancer-binding protein 1
aortic carboxypeptidase-like protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129.4NP_001120.3  adipocyte enhancer-binding protein 1 precursor

    See proteins identical to NP_001120.3

    Status: REVIEWED

    Source sequence(s)
    BC038588, BM672693, DB213495
    Consensus CDS
    CCDS5476.1
    UniProtKB/Swiss-Prot
    Q8IUX7
    Related
    ENSP00000223357, OTTHUMP00000159251, ENST00000223357, OTTHUMT00000250993
    Conserved Domains (3) summary
    cd03869
    Location:560903
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cd11308
    Location:907982
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cd00057
    Location:386539
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    44104320..44114565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515162.1XP_011513464.1  

    Conserved Domains (3) summary
    cd03869
    Location:534877
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cd11308
    Location:881956
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cd00057
    Location:360513
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    44147805..44158013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)