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RIPK2 receptor-interacting serine-threonine kinase 2 [ Homo sapiens (human) ]

Gene ID: 8767, updated on 19-Jul-2014
Official Symbol
RIPK2provided by HGNC
Official Full Name
receptor-interacting serine-threonine kinase 2provided by HGNC
Primary source
HGNC:10020
Locus tag
WUGSC:H_RG437L15.1
See related
Ensembl:ENSG00000104312; HPRD:04585; MIM:603455; Vega:OTTHUMG00000163809
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCK; RICK; RIP2; CARD3; GIG30; CARDIAK
Summary
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]
See RIPK2 in Epigenomics, MapViewer
Location:
8q21
Exon count :
11
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 8 NC_000008.11 (89757733..89791064)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (90769335..90803292)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene keratin, type II cytoskeletal 8-like Neighboring gene uncharacterized LOC101929709 Neighboring gene uncharacterized LOC101929758 Neighboring gene cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) pseudogene 6 Neighboring gene oxidative stress induced growth inhibitor family member 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common genetic variation and performance on standardized cognitive tests.
NHGRI GWA Catalog
Genomewide association study of leprosy.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
CARD domain binding IDA
Inferred from Direct Assay
more info
PubMed 
CARD domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
LIM domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
signal transducer activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
JNK cascade TAS
Traceable Author Statement
more info
 
MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
MyD88-independent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
TRIF-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of MAPK activity TAS
Traceable Author Statement
more info
 
adaptive immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipoteichoic acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to muramyl dipeptide IDA
Inferred from Direct Assay
more info
 
cellular response to peptidoglycan IEA
Inferred from Electronic Annotation
more info
 
defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
innate immune response IDA
Inferred from Direct Assay
more info
 
innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS
Traceable Author Statement
more info
 
nucleotide-binding oligomerization domain containing 1 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
Inferred from Direct Assay
more info
 
nucleotide-binding oligomerization domain containing signaling pathway TAS
Traceable Author Statement
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
 
positive regulation of T-helper 1 cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T-helper 1 type immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of alpha-beta T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chemokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of immature T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interferon-alpha production NAS
Non-traceable Author Statement
more info
 
positive regulation of interferon-beta production NAS
Non-traceable Author Statement
more info
 
positive regulation of interferon-gamma production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-12 production NAS
Non-traceable Author Statement
more info
 
positive regulation of interleukin-2 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 
positive regulation of peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 
positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein ubiquitination NAS
Non-traceable Author Statement
more info
 
positive regulation of transcription from RNA polymerase II promoter NAS
Non-traceable Author Statement
more info
 
positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
response to exogenous dsRNA IEA
Inferred from Electronic Annotation
more info
 
response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
response to interleukin-12 IEA
Inferred from Electronic Annotation
more info
 
response to interleukin-18 IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
stress-activated MAPK cascade TAS
Traceable Author Statement
more info
 
toll-like receptor 10 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 2 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
toll-like receptor 2 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 3 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 4 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 5 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 9 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor TLR1:TLR2 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor TLR6:TLR2 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytoskeleton IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
protein complex IDA
Inferred from Direct Assay
more info
 
vesicle IDA
Inferred from Direct Assay
more info
 
Preferred Names
receptor-interacting serine/threonine-protein kinase 2
Names
receptor-interacting serine/threonine-protein kinase 2
RIP-2
CARD-carrying kinase
growth-inhibiting gene 30
tyrosine-protein kinase RIPK2
receptor-interacting protein 2
CARD-containing IL-1 beta ICE-kinase
CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase
receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase
NP_003812.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033016.1 

    Range
    5001..38318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003821.5NP_003812.1  receptor-interacting serine/threonine-protein kinase 2

    See proteins identical to NP_003812.1

    Status: REVIEWED

    Source sequence(s)
    AI824070, AY358814, DA040898
    Consensus CDS
    CCDS6247.1
    UniProtKB/Swiss-Prot
    O43353
    Related
    ENSP00000220751, OTTHUMP00000224990, ENST00000220751, OTTHUMT00000375686
    Conserved Domains (3) summary
    cd08786
    Location:438524
    Blast Score: 438
    CARD_RIP2_CARD3; Caspase activation and recruitment domain of Receptor Interacting Protein 2
    pfam00069
    Location:21287
    Blast Score: 453
    Pkinase; Protein kinase domain
    cl09925
    Location:22291
    Blast Score: 401
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000008.11 

    Range
    89757733..89791064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251092.2XP_005251149.1  

    See proteins identical to XP_005251149.1

    UniProtKB/Swiss-Prot
    O43353
    Conserved Domains (2) summary
    cd08786
    Location:301387
    Blast Score: 431
    CARD_RIP2_CARD3; Caspase activation and recruitment domain of Receptor Interacting Protein 2
    cl09925
    Location:4154
    Blast Score: 226
    PKc_like; Protein Kinases, catalytic domain

Alternate HuRef

Genomic

  1. AC_000140.1 

    Range
    85980380..86013697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 

    Range
    90811006..90844310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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