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    BCL2L11 BCL2-like 11 (apoptosis facilitator) [ Homo sapiens (human) ]

    Gene ID: 10018, updated on 30-Jun-2015
    Official Symbol
    BCL2L11provided by HGNC
    Official Full Name
    BCL2-like 11 (apoptosis facilitator)provided by HGNC
    Primary source
    HGNC:HGNC:994
    See related
    Ensembl:ENSG00000153094; HPRD:04828; MIM:603827; Vega:OTTHUMG00000131256
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BAM; BIM; BOD
    Summary
    The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]
    Orthologs
    See BCL2L11 in Epigenomics, MapViewer
    Location:
    2q13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (111120618..111168445)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (111878491..111926022)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene acyl-CoA oxidase-like Neighboring gene uncharacterized LOC105373556 Neighboring gene uncharacterized LOC400997 Neighboring gene uncharacterized LOC101927260 Neighboring gene uncharacterized LOC101927283

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
    NHGRI GWA Catalog
    A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
    NHGRI GWA Catalog
    Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
    NHGRI GWA Catalog
    Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.
    NHGRI GWA Catalog
    Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates BIM expression in Tat-infected Jurkat T cells PubMed
    tat HIV-1 Tat acetylation at position K28 stimulates its activity to induce the translocation of Bim, a pro-apoptotic protein of the Bcl-2 family, from microtubules to mitochondria PubMed
    tat HIV-1 Tat (amino acids 36-39) binds tubulin alpha/beta dimers and polymerized microtubules leading to the alteration of microtubule dynamics and activation of a mitochondria-dependent apoptotic pathway that is facilitated by the Bcl-2 relative Bim PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    B cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    T cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    apoptotic process involved in embryonic digit morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    brain development IEA
    Inferred from Electronic Annotation
    more info
     
    cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular process regulating host cell cycle in response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    developmental pigmentation IEA
    Inferred from Electronic Annotation
    more info
     
    ear development IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kidney development IEA
    Inferred from Electronic Annotation
    more info
     
    male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland development IEA
    Inferred from Electronic Annotation
    more info
     
    myeloid cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    neurotrophin TRK receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of IRE1-mediated unfolded protein response TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    positive regulation of apoptotic process by virus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of fibroblast apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of intrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of mitochondrial membrane permeability involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of release of cytochrome c from mitochondria IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    post-embryonic organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    programmed cell death TAS
    Traceable Author Statement
    more info
     
    regulation of developmental pigmentation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    spleen development IEA
    Inferred from Electronic Annotation
    more info
     
    thymocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    thymus development IEA
    Inferred from Electronic Annotation
    more info
     
    tube formation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    BIM-BCL-2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    BIM-BCL-xl complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    bcl-2-like protein 11
    Names
    bcl-2 interacting mediator of cell death
    bcl-2 interacting protein Bim
    bcl-2-related ovarian death agonist

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029006.1 RefSeqGene

      Range
      5001..52532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_620

    mRNA and Protein(s)

    1. NM_001204106.1NP_001191035.1  bcl-2-like protein 11 isoform 11

      See identical proteins and their annotated locations for NP_001191035.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11, also known as BimS) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (11) is shorter, compared to isoform 1.
      Source sequence(s)
      AC096670, AI268146, AK290377, AY305714
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:4676
      Bclx_interact; Bcl-x interacting, BH3 domain
    2. NM_001204107.1NP_001191036.1  bcl-2-like protein 11 isoform 12

      See identical proteins and their annotated locations for NP_001191036.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) uses an alternate in-frame splice site in the 5' coding region, contains two alternate internal exons, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (12) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AC096670, AI268146, AK290377, AY423442
      Consensus CDS
      CCDS56132.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000481423, ENST00000615946
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:4676
      Bclx_interact; Bcl-x interacting, BH3 domain
    3. NM_001204108.1NP_001191037.1  bcl-2-like protein 11 isoform 13

      See identical proteins and their annotated locations for NP_001191037.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (13) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AC096670, AI268146, AK290377, AY423443
      Consensus CDS
      CCDS56135.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000482175, ENST00000622509
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:131166
      Bclx_interact; Bcl-x interacting, BH3 domain
    4. NM_001204109.1NP_001191038.1  bcl-2-like protein 11 isoform 14

      See identical proteins and their annotated locations for NP_001191038.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) lacks an internal exon, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (14) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AC096670, AI268146, AK290377, AY428962
      Consensus CDS
      CCDS56136.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000481030, ENST00000610735
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    5. NM_001204110.1NP_001191039.1  bcl-2-like protein 11 isoform 15

      See identical proteins and their annotated locations for NP_001191039.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) uses an alternate in-frame splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (15) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AC096670, AI268146, AK290377, DQ849200
      Consensus CDS
      CCDS56133.1
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:4676
      Bclx_interact; Bcl-x interacting, BH3 domain
    6. NM_001204111.1NP_001191040.1  bcl-2-like protein 11 isoform 16

      See identical proteins and their annotated locations for NP_001191040.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) lacks an in-frame segment in the 5' coding region, and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (16) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC096670, AI268146, AK290377, DQ849201
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    7. NM_001204112.1NP_001191041.1  bcl-2-like protein 11 isoform 17

      See identical proteins and their annotated locations for NP_001191041.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) lacks an alternate in-frame segment in the 5' coding region, lacks an internal exon, and contains an alternate internal exon, compared to variant 1. The resulting isoform (17) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AC096670, AI268146, AK290377, DQ849202
      Consensus CDS
      CCDS56131.1
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    8. NM_001204113.1NP_001191042.1  bcl-2-like protein 11 isoform 18

      See identical proteins and their annotated locations for NP_001191042.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) lacks an alternate in-frame segment and differs in the 3' UTR and coding sequence, compared to variant 1. The resulting isoform (18) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC096670, AK290377, AW629314
      Consensus CDS
      CCDS74559.1
      UniProtKB/TrEMBL
      A0A0A0MRE7
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000350398, ENST00000357757
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    9. NM_006538.4NP_006529.1  bcl-2-like protein 11 isoform 6

      See identical proteins and their annotated locations for NP_006529.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6, also known as BimL) lacks an in-frame segment in the 5' coding coding region, compared to variant 1. The resulting isoform (6) is shorter, compared to isoform 1.
      Source sequence(s)
      AC096670, AF032458, AI268146, AK290377, BC033694
      Consensus CDS
      CCDS42731.1
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:71106
      Bclx_interact; Bcl-x interacting, BH3 domain
    10. NM_138621.4NP_619527.1  bcl-2-like protein 11 isoform 1

      See identical proteins and their annotated locations for NP_619527.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as BimEL) encodes the longest isoform (1).
      Source sequence(s)
      AC096670, AI268146, BC033694
      Consensus CDS
      CCDS2089.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000376943, OTTHUMP00000161927, ENST00000393256, OTTHUMT00000254022
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:131166
      Bclx_interact; Bcl-x interacting, BH3 domain
    11. NM_138622.3NP_619528.1  bcl-2-like protein 11 isoform 2

      See identical proteins and their annotated locations for NP_619528.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as Bim-alpha1) contains an alternate internal exon and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AB071195, AC096670, AI268146, AK290377
      Consensus CDS
      CCDS74560.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000481652, ENST00000621302
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:131166
      Bclx_interact; Bcl-x interacting, BH3 domain
    12. NM_138623.3NP_619529.1  bcl-2-like protein 11 isoform 3

      See identical proteins and their annotated locations for NP_619529.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as Bim-ACD and Bim-alpha2) lacks a 5' segment, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AB071196, AC096670, AI268146, AK290377
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000478133, ENST00000620862
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:71106
      Bclx_interact; Bcl-x interacting, BH3 domain
    13. NM_138624.3NP_619530.1  bcl-2-like protein 11 isoform 4

      See identical proteins and their annotated locations for NP_619530.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as Bim-beta1) contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AB071197, AC096670, AI268146, AK290377
      Consensus CDS
      CCDS56134.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000479714, ENST00000619294
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    14. NM_138625.3NP_619531.1  bcl-2-like protein 11 isoform 5

      See identical proteins and their annotated locations for NP_619531.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as Bim-beta3) uses an alternate splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AB071199, AC096670, AI268146, AK290377
      UniProtKB/TrEMBL
      A0A0C4DH20
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    15. NM_138626.3NP_619532.1  bcl-2-like protein 11 isoform 7

      See identical proteins and their annotated locations for NP_619532.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7, also known as Bim-ABC and Bim-beta2) lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (7) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB071198, AC096670, AI268146, AK290377
      Consensus CDS
      CCDS74561.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000484360, ENST00000622612
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    16. NM_138627.3NP_619533.1  bcl-2-like protein 11 isoform 8

      See identical proteins and their annotated locations for NP_619533.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8, also known as Bim-A and Bim-beta4) uses an alternate splice site in the 5' coding region, and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (8) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB071200, AC096670, AI268146, AK290377
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    17. NM_207002.3NP_996885.1  bcl-2-like protein 11 isoform 9

      See identical proteins and their annotated locations for NP_996885.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9, also known as Bim-gamma) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (9) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AA890664, AC096670, AK290377, AY352518
      Consensus CDS
      CCDS2092.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000338374, ENST00000337565
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    18. NM_207003.2NP_996886.1  bcl-2-like protein 11 isoform 10

      See identical proteins and their annotated locations for NP_996886.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10, also known as Bim-alpha3) uses an alternate splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (10) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AC096670, AI268146, AK290377, AY305715
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:4676
      Bclx_interact; Bcl-x interacting, BH3 domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

      Range
      111120618..111168445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510463.1XP_011508765.1  

      Conserved Domains (2) summary
      pfam06773
      Location:2157
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:148183
      Bclx_interact; Bcl-x interacting, BH3 domain
    2. XM_005263556.2XP_005263613.1  

      See identical proteins and their annotated locations for XP_005263613.1

      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:131166
      Bclx_interact; Bcl-x interacting, BH3 domain
    3. XM_005263561.2XP_005263618.1  

      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:71106
      Bclx_interact; Bcl-x interacting, BH3 domain
    4. XM_005263551.1XP_005263608.1  

      Conserved Domains (2) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:225260
      Bclx_interact; Bcl-x interacting, BH3 domain
    5. XM_005263554.1XP_005263611.1  

      Conserved Domains (1) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
    6. XM_005263553.1XP_005263610.1  

      Conserved Domains (2) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:165200
      Bclx_interact; Bcl-x interacting, BH3 domain
    7. XM_005263559.1XP_005263616.1  

      Conserved Domains (2) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:140170
      Bclx_interact; Bcl-x interacting, BH3 domain
    8. XM_005263550.2XP_005263607.1  

      Conserved Domains (2) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:225260
      Bclx_interact; Bcl-x interacting, BH3 domain
    9. XM_005263552.2XP_005263609.1  

      Conserved Domains (2) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:165200
      Bclx_interact; Bcl-x interacting, BH3 domain
    10. XM_005263555.2XP_005263612.1  

      Conserved Domains (2) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:136170
      Bclx_interact; Bcl-x interacting, BH3 domain
    11. XM_011510462.1XP_011508764.1  

      Conserved Domains (1) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
    12. XM_011510465.1XP_011508767.1  

      Conserved Domains (1) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
    13. XM_011510461.1XP_011508763.1  

      Conserved Domains (1) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
    14. XM_011510464.1XP_011508766.1  

      Conserved Domains (1) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
    15. XM_005263557.3XP_005263614.1  

      See identical proteins and their annotated locations for XP_005263614.1

      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:131166
      Bclx_interact; Bcl-x interacting, BH3 domain

    RNA

    1. XR_244801.1 RNA Sequence

    2. XR_922830.1 RNA Sequence

    3. XR_922829.1 RNA Sequence

    4. XR_922828.1 RNA Sequence

    5. XR_244802.2 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      111882732..111930286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)