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KLF4 Kruppel-like factor 4 (gut) [ Homo sapiens (human) ]

Gene ID: 9314, updated on 24-May-2015
Official Symbol
KLF4provided by HGNC
Official Full Name
Kruppel-like factor 4 (gut)provided by HGNC
Primary source
HGNC:HGNC:6348
See related
Ensembl:ENSG00000136826; MIM:602253; Vega:OTTHUMG00000020449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EZF; GKLF
Orthologs
See KLF4 in MapViewer
Location:
9q31
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (107484852..107489766, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (110247133..110252047, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene glutamate receptor ionotropic, NMDA 2D-like Neighboring gene RAD23 homolog B (S. cerevisiae) Neighboring gene long intergenic non-protein coding RNA 1509 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 32 Neighboring gene uncharacterized LOC105376206 Neighboring gene uncharacterized LOC105376205

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4.
NHGRI GWA Catalog
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA polymerase II transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription IDA
Inferred from Direct Assay
more info
PubMed 
core promoter proximal region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
sequence-specific DNA binding transcription factor recruiting transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription cofactor binding IEA
Inferred from Electronic Annotation
more info
 
transcription regulatory region DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular response to cycloheximide IEA
Inferred from Electronic Annotation
more info
 
cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to laminar fluid shear stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to peptide IEA
Inferred from Electronic Annotation
more info
 
epidermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
epidermis morphogenesis IEA
Inferred from Electronic Annotation
more info
 
fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
mesodermal cell fate determination TAS
Traceable Author Statement
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of chemokine (C-X-C motif) ligand 2 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of heterotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of inflammatory response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of interleukin-8 biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of muscle hyperplasia IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of response to cytokine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cellular protein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hemoglobin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of telomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
post-embryonic camera-type eye development IEA
Inferred from Electronic Annotation
more info
 
post-embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of phosphatidylinositol 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
somatic stem cell maintenance TAS
Traceable Author Statement
more info
 
stem cell maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
Krueppel-like factor 4
Names
Krueppel-like factor 4
endothelial Kruppel-like zinc finger protein
epithelial zinc finger protein EZF
gut-enriched krueppel-like factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004235.4NP_004226.3  Krueppel-like factor 4

    See identical proteins and their annotated locations for NP_004226.3

    Status: VALIDATED

    Source sequence(s)
    AF105036, AL360218, BU739190, DN995850
    Consensus CDS
    CCDS6770.2
    UniProtKB/Swiss-Prot
    O43474
    Related
    ENSP00000363804, OTTHUMP00000021862, ENST00000374672, OTTHUMT00000053556
    Conserved Domains (2) summary
    COG5048
    Location:391474
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:442467
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    107484852..107489766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252305.1XP_005252362.1  

    See identical proteins and their annotated locations for XP_005252362.1

    UniProtKB/Swiss-Prot
    O43474
    Conserved Domains (2) summary
    COG5048
    Location:425508
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:476501
    zf-H2C2_2; Zinc-finger double domain

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    110393822..110398611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)