Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    NARS asparaginyl-tRNA synthetase [ Homo sapiens (human) ]

    Gene ID: 4677, updated on 9-Jun-2016
    Official Symbol
    NARSprovided by HGNC
    Official Full Name
    asparaginyl-tRNA synthetaseprovided by HGNC
    Primary source
    HGNC:HGNC:7643
    See related
    Ensembl:ENSG00000134440 HPRD:00154; MIM:108410; Vega:OTTHUMG00000180125
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASNRS; NARS1
    Summary
    Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    18q21.31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 18 NC_000018.10 (57600656..57621945, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (55267888..55289177, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene one cut homeobox 2 Neighboring gene ferrochelatase Neighboring gene uncharacterized LOC100505549 Neighboring gene ATPase phospholipid transporting 8B1 Neighboring gene transfer RNA-Gly (TCC) 5-1

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, asparaginyl-tRNA synthetase (NARS), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with NARS is decreased by RRE PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    asparagine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    asparaginyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA aminoacylation for protein translation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    asparagine--tRNA ligase, cytoplasmic
    Names
    asparagine tRNA ligase 1, cytoplasmic
    asparaginyl-tRNA synthetase, cytoplasmic
    NP_004530.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004539.3NP_004530.1  asparagine--tRNA ligase, cytoplasmic

      See identical proteins and their annotated locations for NP_004530.1

      Status: VALIDATED

      Source sequence(s)
      BC001687, DC302277, U79254
      Consensus CDS
      CCDS32837.1
      UniProtKB/Swiss-Prot
      O43776
      Related
      ENSP00000256854, OTTHUMP00000263398, ENST00000256854, OTTHUMT00000449872
      Conserved Domains (3) summary
      COG0017
      Location:125548
      AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd00776
      Location:225544
      AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
      cd04323
      Location:127209
      AsnRS_cyto_like_N; AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p7 Primary Assembly

      Range
      57600656..57621945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005266700.1XP_005266757.1  

      See identical proteins and their annotated locations for XP_005266757.1

      Conserved Domains (3) summary
      COG0017
      Location:124547
      AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd00776
      Location:224543
      AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
      cd04323
      Location:126208
      AsnRS_cyto_like_N; AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018929.2 Alternate CHM1_1.1

      Range
      55263118..55284404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)