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IFIT3 interferon-induced protein with tetratricopeptide repeats 3 [ Homo sapiens (human) ]

Gene ID: 3437, updated on 13-Jan-2015
Official Symbol
IFIT3provided by HGNC
Official Full Name
interferon-induced protein with tetratricopeptide repeats 3provided by HGNC
Primary source
HGNC:HGNC:5411
Locus tag
RP11-149I23.4
See related
Ensembl:ENSG00000119917; HPRD:05228; MIM:604650; Vega:OTTHUMG00000018708
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P60; IRG2; IFI60; IFIT4; ISG60; RIG-G; CIG-49; GARG-49
Orthologs
See IFIT3 in Epigenomics, MapViewer
Location:
10q24
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 10 NC_000010.11 (89327845..89340968)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (91087602..91100725)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene lipase A, lysosomal acid, cholesterol esterase Neighboring gene interferon-induced protein with tetratricopeptide repeats 2 Neighboring gene uncharacterized LOC101926887 Neighboring gene interferon-induced protein with tetratricopeptide repeats 6, pseudogene Neighboring gene interferon-induced protein with tetratricopeptide repeats 1B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 and the viral protein Tat modulate the expression of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3; IFIT4) in immature dendritic cells and monocyte-derived macrophages PubMed
tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including IFIT4, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
Vif vif HIV-1 Vif downregulates the expression of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3/4) in Vif-expression T cells PubMed
Vpu vpu The expression of IFIT3 is enhanced in Vpu-deficient HIV-1-infected cells as compared to that in wild-type-infected cells PubMed

Go to the HIV-1, Human Interaction Database

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
    Interferon alpha/beta signaling, organism-specific biosystemType I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, wher...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to interferon-alpha IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
interferon-induced protein with tetratricopeptide repeats 3
Names
interferon-induced protein with tetratricopeptide repeats 3
CIG49
IFIT-3
IFIT-4
ISG-60
IFI-60K
interferon-induced 60 kDa protein
retinoic acid-induced gene G protein
interferon-induced protein with tetratricopeptide repeats 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031683.3NP_001026853.1  interferon-induced protein with tetratricopeptide repeats 3 isoform a

    See proteins identical to NP_001026853.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. Variants 1 and 2 both encode isoform a, using different start codons but encoding identical proteins.
    Source sequence(s)
    AL353751, BC001383, BM790031, DB268497
    Consensus CDS
    CCDS31241.1
    UniProtKB/Swiss-Prot
    O14879
    UniProtKB/TrEMBL
    Q5T765
    Related
    ENSP00000360876, OTTHUMP00000020060, ENST00000371811, OTTHUMT00000049295
    Conserved Domains (4) summary
    PRK02603
    Location:184341
    PRK02603; photosystem I assembly protein Ycf3; Provisional
    cd00189
    Location:213288
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam13414
    Location:141204
    TPR_11; TPR repeat
    pfam13424
    Location:51126
    TPR_12; Tetratricopeptide repeat
  2. NM_001289758.1NP_001276687.1  interferon-induced protein with tetratricopeptide repeats 3 isoform b

    See proteins identical to NP_001276687.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon compared to variant 1. The resulting isoform (b) uses a translation initiation site at a downstream AUG that results in an isoform (b) with a shorter N-terminus compared to isoform 1. Variants 3 and 4 both encode the same isoform (b).
    Source sequence(s)
    AL353751, BM790031, DA160435, DA673951
    Conserved Domains (3) summary
    PRK02603
    Location:132289
    PRK02603; photosystem I assembly protein Ycf3; Provisional
    cd00189
    Location:161236
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam13424
    Location:174
    TPR_12; Tetratricopeptide repeat
  3. NM_001289759.1NP_001276688.1  interferon-induced protein with tetratricopeptide repeats 3 isoform b

    See proteins identical to NP_001276688.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and contains an alternate exon compared to variant 1. The resulting isoform (b) uses a translation initiation site at a downstream AUG that results in an isoform (b) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL353751, BM790031, BU509201, DB268497
    Conserved Domains (3) summary
    PRK02603
    Location:132289
    PRK02603; photosystem I assembly protein Ycf3; Provisional
    cd00189
    Location:161236
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam13424
    Location:174
    TPR_12; Tetratricopeptide repeat
  4. NM_001549.5NP_001540.2  interferon-induced protein with tetratricopeptide repeats 3 isoform a

    See proteins identical to NP_001540.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1 and 2 both encode isoform a, using different start codons but encoding identical proteins.
    Source sequence(s)
    AK290427, AL353751, BM790031, DA160435
    Consensus CDS
    CCDS7402.1
    UniProtKB/Swiss-Prot
    O14879
    UniProtKB/TrEMBL
    Q5T765
    Related
    ENSP00000360883, OTTHUMP00000020059, ENST00000371818, OTTHUMT00000049294
    Conserved Domains (4) summary
    PRK02603
    Location:184341
    PRK02603; photosystem I assembly protein Ycf3; Provisional
    cd00189
    Location:213288
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam13414
    Location:141204
    TPR_11; TPR repeat
    pfam13424
    Location:51126
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000010.11 

    Range
    89327845..89340968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 

    Range
    91369659..91382788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000142.1 

    Range
    84721782..84734913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)