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    CSE1L CSE1 chromosome segregation 1-like (yeast) [ Homo sapiens (human) ]

    Gene ID: 1434, updated on 30-Jun-2015
    Official Symbol
    CSE1Lprovided by HGNC
    Official Full Name
    CSE1 chromosome segregation 1-like (yeast)provided by HGNC
    Primary source
    HGNC:HGNC:2431
    See related
    Ensembl:ENSG00000124207; HPRD:03217; MIM:601342; Vega:OTTHUMG00000033046
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAS; CSE1; XPO2
    Summary
    Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
    Orthologs
    See CSE1L in Epigenomics, MapViewer
    Location:
    20q13
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 20 NC_000020.11 (49046246..49096960)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (47662783..47713497)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene CSE1L antisense RNA 1 Neighboring gene synaptosomal-associated protein, 23kDa pseudogene Neighboring gene staufen double-stranded RNA binding protein 1 Neighboring gene actin related protein 2/3 complex, subunit 3 pseudogene 1 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 27

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of proneness to anger.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates chromosome segregation 1-like (yeast) in HEK 293T cells PubMed
    integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies nuclear import-export proteins Exp2 and RanBP9 as IN-binding partners PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC117283, MGC130036, MGC130037

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Ran GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    importin-alpha export receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    protein export from nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    exportin-2
    Names
    cellular apoptosis susceptibility protein
    chromosome segregation 1-like protein
    exp2
    importin-alpha re-exporter

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256135.1NP_001243064.1  exportin-2 isoform 2

      See identical proteins and their annotated locations for NP_001243064.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AI018123, AI973168, BC109314, DC402014, EF426455
      Consensus CDS
      CCDS58773.1
      UniProtKB/Swiss-Prot
      P55060
      Related
      ENSP00000379495, ENST00000396192
      Conserved Domains (4) summary
      smart00913
      Location:29102
      IBN_N; Importin-beta N-terminal domain
      COG5657
      Location:21879
      CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
      pfam03378
      Location:471906
      CAS_CSE1; CAS/CSE protein, C-terminus
      pfam08506
      Location:156470
      Cse1; Cse1
    2. NM_001316.3NP_001307.2  exportin-2 isoform 1

      See identical proteins and their annotated locations for NP_001307.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).
      Source sequence(s)
      AI018123, AI973168, BC109314, DC402014
      Consensus CDS
      CCDS13412.1
      UniProtKB/Swiss-Prot
      P55060
      Related
      ENSP00000262982, OTTHUMP00000043373, ENST00000262982, OTTHUMT00000080345
      Conserved Domains (4) summary
      smart00913
      Location:29102
      IBN_N; Importin-beta N-terminal domain
      COG5657
      Location:21935
      CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
      pfam03378
      Location:527962
      CAS_CSE1; CAS/CSE protein, C-terminus
      pfam08506
      Location:156526
      Cse1; Cse1

    RNA

    1. NR_045796.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks 3 consecutive exons, and uses alternate splice sites at 2 other exons compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon (with a strong Kozak signal), as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI018123, AI973168, AK300589, BC109314, DC402014

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p2 Primary Assembly

      Range
      49046246..49096960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528599.1XP_011526901.1  

      Conserved Domains (4) summary
      smart00913
      Location:29102
      IBN_N; Importin-beta N-terminal domain
      COG5657
      Location:21935
      CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
      pfam03378
      Location:527942
      CAS_CSE1; CAS/CSE protein, C-terminus
      pfam08506
      Location:156526
      Cse1; Cse1

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      47567020..47617675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177436.1: Suppressed sequence

      Description
      NM_177436.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.