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    INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa [ Homo sapiens (human) ]

    Gene ID: 8821, updated on 26-Jun-2015
    Official Symbol
    INPP4Bprovided by HGNC
    Official Full Name
    inositol polyphosphate-4-phosphatase, type II, 105kDaprovided by HGNC
    Primary source
    HGNC:HGNC:6075
    See related
    Ensembl:ENSG00000109452; HPRD:06322; MIM:607494; Vega:OTTHUMG00000161341
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]
    Orthologs
    See INPP4B in Epigenomics, MapViewer
    Location:
    4q31.21
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (142028028..142846535, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (142949181..143767604, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377456 Neighboring gene interleukin 15 Neighboring gene ribosomal protein L5 pseudogene 13 Neighboring gene LSM3 U6 small nuclear RNA and mRNA degradation associated pseudogene 4 Neighboring gene uncharacterized LOC101927613 Neighboring gene uncharacterized LOC105377457 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 4 pseudogene Neighboring gene uncharacterized LOC105377623 Neighboring gene ubiquitin specific peptidase 38

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC132014

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol trisphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    inositol phosphate metabolic process TAS
    Traceable Author Statement
    more info
     
    negative regulation of osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol biosynthetic process TAS
    Traceable Author Statement
    more info
     
    phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-3-phosphate biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    phospholipid metabolic process TAS
    Traceable Author Statement
    more info
     
    regulation of bone remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    type II inositol 3,4-bisphosphate 4-phosphatase
    Names
    type II inositol 3,4-bisphosphate 4-phosphatase
    inositol polyphosphate 4-phosphatase II; 4-phosphatase II
    inositol polyphosphate 4-phosphatase type II
    inositol polyphosphate-4-phosphatase, type II, 105kD
    type II inositol-3,4-bisphosphate 4-phosphatase
    NP_001095139.1
    NP_003857.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101669.1NP_001095139.1  type II inositol 3,4-bisphosphate 4-phosphatase

      See identical proteins and their annotated locations for NP_001095139.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      BC017924, BC072447, BP360389, BX649090
      Consensus CDS
      CCDS3757.1
      UniProtKB/Swiss-Prot
      O15327
      Related
      ENSP00000262992, ENST00000262992
      Conserved Domains (1) summary
      cd04048
      Location:39175
      C2A_Copine; C2 domain first repeat in Copine
    2. NM_003866.2NP_003857.2  type II inositol 3,4-bisphosphate 4-phosphatase

      See identical proteins and their annotated locations for NP_003857.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      BC017924, BC072447, BP360389, BX649090
      Consensus CDS
      CCDS3757.1
      UniProtKB/Swiss-Prot
      O15327
      Conserved Domains (1) summary
      cd04048
      Location:39175
      C2A_Copine; C2 domain first repeat in Copine

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

      Range
      142028028..142846535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714402.1XP_006714465.1  

      See identical proteins and their annotated locations for XP_006714465.1

      UniProtKB/Swiss-Prot
      O15327
      Related
      ENSP00000423954, OTTHUMP00000220071, ENST00000508116, OTTHUMT00000364593
      Conserved Domains (1) summary
      cd04048
      Location:39175
      C2A_Copine; C2 domain first repeat in Copine
    2. XM_005263322.1XP_005263379.1  

      Conserved Domains (1) summary
      cd04048
      Location:39175
      C2A_Copine; C2 domain first repeat in Copine
    3. XM_011532393.1XP_011530695.1  

      Conserved Domains (1) summary
      cd04048
      Location:39175
      C2A_Copine; C2 domain first repeat in Copine
    4. XM_011532391.1XP_011530693.1  

      See identical proteins and their annotated locations for XP_011530693.1

      Conserved Domains (1) summary
      cd04048
      Location:39175
      C2A_Copine; C2 domain first repeat in Copine
    5. XM_006714400.2XP_006714463.1  

      See identical proteins and their annotated locations for XP_006714463.1

      Conserved Domains (1) summary
      cd04048
      Location:39175
      C2A_Copine; C2 domain first repeat in Copine
    6. XM_011532395.1XP_011530697.1  

      See identical proteins and their annotated locations for XP_011530697.1

    7. XM_011532394.1XP_011530696.1  

      See identical proteins and their annotated locations for XP_011530696.1

    8. XM_011532392.1XP_011530694.1  

      See identical proteins and their annotated locations for XP_011530694.1

      Conserved Domains (1) summary
      cd04048
      Location:39175
      C2A_Copine; C2 domain first repeat in Copine
    9. XM_006714401.2XP_006714464.1  

      See identical proteins and their annotated locations for XP_006714464.1

      UniProtKB/TrEMBL
      E7EQN9
      Conserved Domains (1) summary
      cd04048
      Location:39175
      C2A_Copine; C2 domain first repeat in Copine
    10. XM_006714403.2XP_006714466.1  

    11. XM_005263323.2XP_005263380.1  

      Related
      ENSP00000421065, OTTHUMP00000220069, ENST00000514525, OTTHUMT00000364591
    12. XM_005263325.2XP_005263382.1  

      Related
      ENSP00000426207, OTTHUMP00000220068, ENST00000511838, OTTHUMT00000364590
    13. XM_011532396.1XP_011530698.1  

      Conserved Domains (1) summary
      cd04048
      Location:39175
      C2A_Copine; C2 domain first repeat in Copine
    14. XM_006714404.2XP_006714467.1  

      Conserved Domains (1) summary
      cd04048
      Location:39175
      C2A_Copine; C2 domain first repeat in Copine

    RNA

    1. XR_938791.1 RNA Sequence

    2. XR_938790.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      142926560..143744866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)