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NCOA3 nuclear receptor coactivator 3 [ Homo sapiens (human) ]

Gene ID: 8202, updated on 23-Sep-2014
Official Symbol
NCOA3provided by HGNC
Official Full Name
nuclear receptor coactivator 3provided by HGNC
Primary source
HGNC:HGNC:7670
Locus tag
RP5-1049G16.3
See related
Ensembl:ENSG00000124151; HPRD:03570; MIM:601937; Vega:OTTHUMG00000033061
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42
Summary
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]
See NCOA3 in Epigenomics, MapViewer
Location:
20q12
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 20 NC_000020.11 (47501857..47656877)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (46130601..46285621)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723442 Neighboring gene ribosomal protein L35a pseudogene Neighboring gene ribosomal protein S3A pseudogene Neighboring gene sulfatase 2 Neighboring gene spermidine synthase pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
NHGRI GWA Catalog
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of nuclear receptor coactivator 3 (NCOA3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat NCOA3 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
tat p/CIP binds to HIV-1 Tat and enhances Tat-stimulated HIV-1 LTR promoter transactivation PubMed
tat HIV-1 Tat may function as an adaptor molecule, efficiently stimulating the processes of transcription initiation and elongation through potentiation of the coupling of p160 co-activators and the P-TEFb complex PubMed
nucleocapsid gag Nuclear receptor coactivator 3 (NCOA3) is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC141848

Gene Ontology Provided by GOA

Function Evidence Code Pubs
androgen receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ligand-dependent nuclear receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ligand-dependent nuclear receptor transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 
nuclear hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
thyroid hormone receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
androgen receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
developmental growth IEA
Inferred from Electronic Annotation
more info
 
histone acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone acetylation IEA
Inferred from Electronic Annotation
more info
 
labyrinthine layer morphogenesis IEA
Inferred from Electronic Annotation
more info
 
mammary gland branching involved in thelarche IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
receptor transactivation TAS
Traceable Author Statement
more info
PubMed 
regulation of RNA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
vagina development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
nuclear receptor coactivator 3
Names
nuclear receptor coactivator 3
CBP-interacting protein
receptor-associated coactivator 3
amplified in breast cancer 1 protein
steroid receptor coactivator protein 3
class E basic helix-loop-helix protein 42
thyroid hormone receptor activator molecule 1
NP_001167558.1
NP_001167559.1
NP_006525.2
NP_858045.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016810.1 

    Range
    5001..160021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001174087.1NP_001167558.1  nuclear receptor coactivator 3 isoform c

    See proteins identical to NP_001167558.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (c) compared to isoform a.
    Source sequence(s)
    AB209863, AL034418, DB091786
    UniProtKB/TrEMBL
    Q59EE8
    Conserved Domains (6) summary
    pfam08815
    Location:10451092
    Nuc_rec_co-act; Nuclear receptor coactivator
    cd00083
    Location:3487
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:121186
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:12901347
    DUF1518; Domain of unknown function (DUF1518)
    pfam08832
    Location:618704
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:264375
    PAS_11; PAS domain
  2. NM_001174088.1NP_001167559.1  nuclear receptor coactivator 3 isoform d

    See proteins identical to NP_001167559.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses three alternate in-frame splice sites compared to variant 1, resulting in a shorter isoform (d) compared to isoform a.
    Source sequence(s)
    AF036892, AL034418, DB091786
    Consensus CDS
    CCDS54472.1
    UniProtKB/Swiss-Prot
    Q9Y6Q9
    Related
    ENSP00000361065, OTTHUMP00000031717, ENST00000371997, OTTHUMT00000080404
    Conserved Domains (6) summary
    pfam08815
    Location:10401087
    Nuc_rec_co-act; Nuclear receptor coactivator
    cd00083
    Location:3487
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:121186
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:12821339
    DUF1518; Domain of unknown function (DUF1518)
    pfam08832
    Location:628714
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:264385
    PAS_11; PAS domain
  3. NM_006534.3NP_006525.2  nuclear receptor coactivator 3 isoform b

    See proteins identical to NP_006525.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.
    Source sequence(s)
    AF012108, AL034418, DB091786
    Consensus CDS
    CCDS13406.1
    UniProtKB/Swiss-Prot
    Q9Y6Q9
    Related
    ENSP00000361073, OTTHUMP00000031716, ENST00000372004, OTTHUMT00000080403
    Conserved Domains (6) summary
    pfam08815
    Location:10451092
    Nuc_rec_co-act; Nuclear receptor coactivator
    cd00083
    Location:3487
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:121186
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:12871344
    DUF1518; Domain of unknown function (DUF1518)
    pfam08832
    Location:618704
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:264375
    PAS_11; PAS domain
  4. NM_181659.2NP_858045.1  nuclear receptor coactivator 3 isoform a

    See proteins identical to NP_858045.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF016031, AL034418, DB091786
    Consensus CDS
    CCDS13407.1
    UniProtKB/Swiss-Prot
    Q9Y6Q9
    Conserved Domains (6) summary
    pfam08815
    Location:10451092
    Nuc_rec_co-act; Nuclear receptor coactivator
    cd00083
    Location:3487
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:121186
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:12911348
    DUF1518; Domain of unknown function (DUF1518)
    pfam08832
    Location:618704
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:264375
    PAS_11; PAS domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 

    Range
    47501857..47656877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000152.1 

    Range
    42872332..43026949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 

    Range
    46033477..46188916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)