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    PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [ Homo sapiens (human) ]

    Gene ID: 5743, updated on 2-Aug-2015
    Official Symbol
    PTGS2provided by HGNC
    Official Full Name
    prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)provided by HGNC
    Primary source
    HGNC:HGNC:9605
    See related
    Ensembl:ENSG00000073756; HPRD:02599; MIM:600262; Vega:OTTHUMG00000035473
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS
    Summary
    Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
    Orthologs
    See PTGS2 in Epigenomics, MapViewer
    Location:
    1q25.2-q25.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (186671812..186680427, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (186640944..186649559, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724919 Neighboring gene phosducin Neighboring gene PARK2 co-regulated-like pseudogene Neighboring gene PTGS2 antisense NFKB1 complex-mediated expression regulator RNA Neighboring gene phospholipase A2, group IVA (cytosolic, calcium-dependent)

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of prostaglandin-endoperoxide synthase 2 (PTGS2) in human B cells PubMed
    env Overexpression of NF-kappaB inhibitory subunit, IkappaBalpha, completely abrogates gp120-induced COX-2 activity PubMed
    env HIV-1 envelope protein gp120 is able to induce COX-2 mRNA and protein in human neuroblastoma cell lines that express CXCR4 and CCR5 but not CD4; gp120 induces COX-2 promoter transcription through NF-kappaB and activating protein-1 (AP-1) sites PubMed
    env HIV-1 clade B gp120 induces higher levels of expression of the neuropathogenic molecule cyclooxygenase-2 (COX-2)-mediated arachidonic acid by-products, prostaglandin E2 (PGE2) and thromboxane A2 receptor (TBXA2R) compared to clade C gp120 PubMed
    env HIV-1 gp120 increases the intracellular concentrations of prostaglandin E2 and leukotriene B4 by upregulating the activity and expression of the arachidonate-metabolizing enzymes prostaglandin H synthase and 5-lipoxygenase, respectively PubMed
    env Preincubation of human astrocytoma cells with HIV-1 gp120 produces a significant increase of nitrite and PGE2 in cell supernatants; the effect of gp120 on both nitrite and PGE2 production is inhibited by antagonists of NO synthase or cyclooxygenase PubMed
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of prostaglandin-endoperoxide synthase 2 (PTGS2; prostaglandin G/H synthase and cyclooxygenase) in peptide-treated PBMCs PubMed
    Tat tat Transcription factors NFAT and AP-1 (c-Jun/c-Fos) are required for HIV-1 Tat-induced upregulation of COX-2 PubMed
    tat HIV-1 Tat-induced cyclooxygenase (COX)-2 expression and prostaglandin E2 (PGE2) synthesis increase Leishmania growth in HIV-1-infected macrophages PubMed
    Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

    Go to the HIV-1, Human Interaction Database

    • Arachidonic acid metabolism, organism-specific biosystem (from KEGG)
      Arachidonic acid metabolism, organism-specific biosystem
      Arachidonic acid metabolism
    • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
      Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
    • Arachidonic acid metabolism, conserved biosystem (from KEGG)
      Arachidonic acid metabolism, conserved biosystem
      Arachidonic acid metabolism
    • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      C-MYB transcription factor network, organism-specific biosystem
      C-MYB transcription factor network
    • C20 prostanoid biosynthesis, organism-specific biosystem (from BIOCYC)
      C20 prostanoid biosynthesis, organism-specific biosystemGeneral Background A subclass of eicosanoids, the C20 prostanoids comprise of prostaglandins, thromboxanes and prostacyclins. They are all lipid compounds derived from the ω6 essential fatty ...
    • C20 prostanoid biosynthesis, conserved biosystem (from BIOCYC)
      C20 prostanoid biosynthesis, conserved biosystemGeneral Background A subclass of eicosanoids, the C20 prostanoids comprise of prostaglandins, thromboxanes and prostacyclins. They are all lipid compounds derived from the ω6 essential fatty ...
    • Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    • Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem (from Pathway Interaction Database)
      Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem
      Calcium signaling in the CD4+ TCR pathway
    • Chemical carcinogenesis, organism-specific biosystem (from KEGG)
      Chemical carcinogenesis, organism-specific biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
    • Chemical carcinogenesis, conserved biosystem (from KEGG)
      Chemical carcinogenesis, conserved biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
    • Eicosanoid Synthesis, organism-specific biosystem (from WikiPathways)
      Eicosanoid Synthesis, organism-specific biosystemIn biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or i...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Metabolism of vitamins and cofactors, organism-specific biosystem (from REACTOME)
      Metabolism of vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only ...
    • Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem (from REACTOME)
      Metabolism of water-soluble vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only ...
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • Nicotinamide salvaging, organism-specific biosystem (from REACTOME)
      Nicotinamide salvaging, organism-specific biosystemNicotinamide (NAM) levels are modulated by the action of three enzymes involved in nicotinamide salvaging. They are nicotinamide deaminase, nicotinamide phosphoribosyltransferase and nicotinate phosp...
    • Nicotinate metabolism, organism-specific biosystem (from REACTOME)
      Nicotinate metabolism, organism-specific biosystemNicotinate (niacin) and nicotinamide are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP+). When NAD+ and NADP+ are intercha...
    • Ovarian steroidogenesis, organism-specific biosystem (from KEGG)
      Ovarian steroidogenesis, organism-specific biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
    • Ovarian steroidogenesis, conserved biosystem (from KEGG)
      Ovarian steroidogenesis, conserved biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
    • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
      Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • Oxytocin signaling pathway, conserved biosystem (from KEGG)
      Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Prostaglandin Synthesis and Regulation, organism-specific biosystem (from WikiPathways)
      Prostaglandin Synthesis and Regulation, organism-specific biosystem
      Prostaglandin Synthesis and Regulation
    • Regulation of lipolysis in adipocytes, organism-specific biosystem (from KEGG)
      Regulation of lipolysis in adipocytes, organism-specific biosystemLipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs as energy substrates, is a unique function of white adipose tissue. ...
    • Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
      Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
    • Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
      Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
    • S1P1 pathway, organism-specific biosystem (from Pathway Interaction Database)
      S1P1 pathway, organism-specific biosystem
      S1P1 pathway
    • Selenium Pathway, organism-specific biosystem (from WikiPathways)
      Selenium Pathway, organism-specific biosystem
      Selenium Pathway
    • Serotonergic synapse, organism-specific biosystem (from KEGG)
      Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
    • Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
      Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem
      Signaling mediated by p38-alpha and p38-beta
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Synthesis of 15-eicosatetraenoic acid derivatives, organism-specific biosystem (from REACTOME)
      Synthesis of 15-eicosatetraenoic acid derivatives, organism-specific biosystemThe 15-eicosatetraenoic acids: 15-hydroperoxy-eicosatetraenoic acid (15-HpETE), 15-hydroxyeicosatetraenoic acid (15-HETE) and 15-oxo-eicosatetraenoic acid (15-oxoETE) are formed after the initial st...
    • Synthesis of Prostaglandins (PG) and Thromboxanes (TX), organism-specific biosystem (from REACTOME)
      Synthesis of Prostaglandins (PG) and Thromboxanes (TX), organism-specific biosystemThe bioactive prostaglandin (PG) signalling molecules, including PGA2, PGE2, PGF2a, and PGI2 (prostacyclin) are synthesised from arachidonic acid and its products by various prostaglandin synthase ty...
    • TNF signaling pathway, organism-specific biosystem (from KEGG)
      TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
    • TNF signaling pathway, conserved biosystem (from KEGG)
      TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
    • VEGF signaling pathway, organism-specific biosystem (from KEGG)
      VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGF signaling pathway, conserved biosystem (from KEGG)
      VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • aspirin triggered resolvin D biosynthesis, organism-specific biosystem (from BIOCYC)
      aspirin triggered resolvin D biosynthesis, organism-specific biosystemGeneral Background The ω 3 polyunsaturated fatty acids are known to be essential for proper neuronal and immune function. Deficiencies in these important fatty acids are associated with mental...
    • aspirin triggered resolvin D biosynthesis, conserved biosystem (from BIOCYC)
      aspirin triggered resolvin D biosynthesis, conserved biosystemGeneral Background The ω 3 polyunsaturated fatty acids are known to be essential for proper neuronal and immune function. Deficiencies in these important fatty acids are associated with mental...
    • aspirin triggered resolvin E biosynthesis, organism-specific biosystem (from BIOCYC)
      aspirin triggered resolvin E biosynthesis, organism-specific biosystemGeneral Background Resolvins (resolution phase interaction products) are a new class of anti-inflammatory mediators derived from the ω 3 fatty acids eicosapentaenoate and docosahexaenoate. Tho...
    • aspirin triggered resolvin E biosynthesis, conserved biosystem (from BIOCYC)
      aspirin triggered resolvin E biosynthesis, conserved biosystemGeneral Background Resolvins (resolution phase interaction products) are a new class of anti-inflammatory mediators derived from the ω 3 fatty acids eicosapentaenoate and docosahexaenoate. Tho...
    • aspirin-triggered lipoxin biosynthesis, organism-specific biosystem (from BIOCYC)
      aspirin-triggered lipoxin biosynthesis, organism-specific biosystemGeneral Background Lipoxins belong to the eicosanoid family, have a distinct conjugated tetraene structure and are generated from : ARACHIDONIC_ACID. These lipid derived mediators play an important ...
    • aspirin-triggered lipoxin biosynthesis, conserved biosystem (from BIOCYC)
      aspirin-triggered lipoxin biosynthesis, conserved biosystemGeneral Background Lipoxins belong to the eicosanoid family, have a distinct conjugated tetraene structure and are generated from |FRAME: ARACHIDONIC_ACID|. These lipid derived mediators play an imp...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    arachidonate 15-lipoxygenase activity TAS
    Traceable Author Statement
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    peroxidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    prostaglandin-endoperoxide synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    NAD metabolic process TAS
    Traceable Author Statement
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    arachidonic acid metabolic process TAS
    Traceable Author Statement
    more info
     
    bone mineralization IEA
    Inferred from Electronic Annotation
    more info
     
    brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to ATP IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to UV IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to fluid shear stress IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cyclooxygenase pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclooxygenase pathway TAS
    Traceable Author Statement
    more info
     
    decidualization IEA
    Inferred from Electronic Annotation
    more info
     
    embryo implantation IEA
    Inferred from Electronic Annotation
    more info
     
    hair cycle IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    learning IEA
    Inferred from Electronic Annotation
    more info
     
    lipoxygenase pathway TAS
    Traceable Author Statement
    more info
     
    maintenance of blood-brain barrier IEA
    Inferred from Electronic Annotation
    more info
     
    memory IEA
    Inferred from Electronic Annotation
    more info
     
    movement of cell or subcellular component TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of synaptic transmission, dopaminergic IEA
    Inferred from Electronic Annotation
    more info
     
    nicotinamide metabolic process TAS
    Traceable Author Statement
    more info
     
    ovulation IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of brown fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of cell migration involved in sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of fever generation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of fibroblast growth factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of platelet-derived growth factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of prostaglandin biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transforming growth factor beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of vascular endothelial growth factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    prostaglandin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    prostaglandin biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    prostaglandin metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of blood pressure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of inflammatory response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    response to fatty acid IEA
    Inferred from Electronic Annotation
    more info
     
    response to fructose IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    response to lithium ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to manganese ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    response to vitamin D IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    vitamin metabolic process TAS
    Traceable Author Statement
    more info
     
    water-soluble vitamin metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    caveola IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    PubMed 
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    prostaglandin G/H synthase 2
    Names
    PGH synthase 2
    PHS II
    cyclooxygenase 2b
    prostaglandin H2 synthase 2
    NP_000954.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028206.2 RefSeqGene

      Range
      5001..13616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000963.3NP_000954.1  prostaglandin G/H synthase 2 precursor

      See identical proteins and their annotated locations for NP_000954.1

      Status: REVIEWED

      Source sequence(s)
      AL033533, BC013734, BM978796, DA277667, KF455116
      Consensus CDS
      CCDS1371.1
      UniProtKB/Swiss-Prot
      P35354
      Related
      ENSP00000356438, OTTHUMP00000033524, ENST00000367468, OTTHUMT00000086157
      Conserved Domains (3) summary
      cd09816
      Location:75562
      prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
      cd00054
      Location:1954
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam03098
      Location:122560
      An_peroxidase; Animal haem peroxidase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

      Range
      186671812..186680427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      188062673..188071288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)