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    CUL2 cullin 2 [ Homo sapiens (human) ]

    Gene ID: 8453, updated on 30-Jun-2015
    Official Symbol
    CUL2provided by HGNC
    Official Full Name
    cullin 2provided by HGNC
    Primary source
    HGNC:HGNC:2552
    See related
    Ensembl:ENSG00000108094; HPRD:06786; MIM:603135; Vega:OTTHUMG00000017950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Orthologs
    See CUL2 in Epigenomics, MapViewer
    Location:
    10p11.21
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (35008551..35126899, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (35297479..35379570, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376491 Neighboring gene uncharacterized LOC105376492 Neighboring gene microRNA 3611 Neighboring gene RNA, U7 small nuclear 77 pseudogene Neighboring gene cAMP responsive element modulator Neighboring gene ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 pseudogene 4

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif is identified to have a physical interaction with Cullin 2 (CUL2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Cellular response to hypoxia, organism-specific biosystem (from REACTOME)
      Cellular response to hypoxia, organism-specific biosystemOxygen plays a central role in the functioning of human cells: it is both essential for normal metabolism and toxic. To begin the annotation of stress responses in Reactome, we have annotated one asp...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • ECV complex, organism-specific biosystem (from KEGG)
      ECV complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • ECV complex, conserved biosystem (from KEGG)
      ECV complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
    • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
      HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
    • Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem (from Pathway Interaction Database)
      Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem
      Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, organism-specific biosystem (from REACTOME)
      Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, organism-specific biosystemHIF-alpha subunits, comprising HIF1A (Bruick and McKnight 2001, Ivan et al. 2001, Jaakkola et al. 2001), HIF2A (Percy et al. 2008, Furlow et al. 2009), and HIF3A (Maynard et al. 2003), are hydroxylat...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Regulation of Hypoxia-inducible Factor (HIF) by oxygen, organism-specific biosystem (from REACTOME)
      Regulation of Hypoxia-inducible Factor (HIF) by oxygen, organism-specific biosystemIn the presence of oxygen members of the transcription factor family HIF-alpha, comprising HIF1A, HIF2A (EPAS1), and HIF3A, are hydroxylated on proline residues by PHD1 (EGLN2), PHD2 (EGLN1), and PHD...
    • Renal cell carcinoma, organism-specific biosystem (from KEGG)
      Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Renal cell carcinoma, conserved biosystem (from KEGG)
      Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Clone Names

    • MGC131970

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Cul2-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198777.1NP_001185706.1  cullin-2 isoform c

      See identical proteins and their annotated locations for NP_001185706.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AI089201, AK095217, AL392046, BC009591
      Consensus CDS
      CCDS7179.1
      UniProtKB/Swiss-Prot
      Q13617
      Related
      ENSP00000363883, OTTHUMP00000019436, ENST00000374751, OTTHUMT00000047537
      Conserved Domains (3) summary
      smart00182
      Location:424568
      CULLIN; Cullin
      pfam00888
      Location:14645
      Cullin; Cullin family
      pfam10557
      Location:672739
      Cullin_Nedd8; Cullin protein neddylation domain
    2. NM_001198778.1NP_001185707.1  cullin-2 isoform a

      See identical proteins and their annotated locations for NP_001185707.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AI089201, AL392046, BC009591, DC401811
      Consensus CDS
      CCDS55709.1
      UniProtKB/Swiss-Prot
      Q13617
      Conserved Domains (3) summary
      smart00182
      Location:443587
      CULLIN; Cullin
      pfam00888
      Location:33664
      Cullin; Cullin family
      pfam10557
      Location:691758
      Cullin_Nedd8; Cullin protein neddylation domain
    3. NM_001198779.1NP_001185708.1  cullin-2 isoform b

      See identical proteins and their annotated locations for NP_001185708.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AI089201, AK310225, AL392046, BC009591, DC401811
      Consensus CDS
      CCDS73086.1
      UniProtKB/TrEMBL
      A0A0A0MTN0
      UniProtKB/Swiss-Prot
      Q13617
      Related
      ENSP00000444856, ENST00000537177
      Conserved Domains (3) summary
      smart00182
      Location:437581
      CULLIN; Cullin
      pfam00888
      Location:27658
      Cullin; Cullin family
      pfam10557
      Location:685752
      Cullin_Nedd8; Cullin protein neddylation domain
    4. NM_003591.3NP_003582.2  cullin-2 isoform c

      See identical proteins and their annotated locations for NP_003582.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AI089201, AL392046, BC009591, DC401936
      Consensus CDS
      CCDS7179.1
      UniProtKB/Swiss-Prot
      Q13617
      Related
      ENSP00000363881, OTTHUMP00000019440, ENST00000374749, OTTHUMT00000047542
      Conserved Domains (3) summary
      smart00182
      Location:424568
      CULLIN; Cullin
      pfam00888
      Location:14645
      Cullin; Cullin family
      pfam10557
      Location:672739
      Cullin_Nedd8; Cullin protein neddylation domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

      Range
      35008551..35126899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519745.1XP_011518047.1  

      See identical proteins and their annotated locations for XP_011518047.1

      Conserved Domains (3) summary
      smart00182
      Location:487631
      CULLIN; Cullin
      pfam00888
      Location:77708
      Cullin; Cullin family
      pfam10557
      Location:735802
      Cullin_Nedd8; Cullin protein neddylation domain
    2. XM_011519743.1XP_011518045.1  

      See identical proteins and their annotated locations for XP_011518045.1

      Conserved Domains (3) summary
      smart00182
      Location:487631
      CULLIN; Cullin
      pfam00888
      Location:77708
      Cullin; Cullin family
      pfam10557
      Location:735802
      Cullin_Nedd8; Cullin protein neddylation domain
    3. XM_011519744.1XP_011518046.1  

      See identical proteins and their annotated locations for XP_011518046.1

      Conserved Domains (3) summary
      smart00182
      Location:487631
      CULLIN; Cullin
      pfam00888
      Location:77708
      Cullin; Cullin family
      pfam10557
      Location:735802
      Cullin_Nedd8; Cullin protein neddylation domain
    4. XM_011519747.1XP_011518049.1  

      See identical proteins and their annotated locations for XP_011518049.1

      Related
      ENSP00000363880, OTTHUMP00000019437, ENST00000374748, OTTHUMT00000047538
      Conserved Domains (3) summary
      smart00182
      Location:424568
      CULLIN; Cullin
      pfam00888
      Location:14645
      Cullin; Cullin family
      pfam10557
      Location:672739
      Cullin_Nedd8; Cullin protein neddylation domain
    5. XM_011519746.1XP_011518048.1  

      See identical proteins and their annotated locations for XP_011518048.1

      Conserved Domains (3) summary
      smart00182
      Location:424568
      CULLIN; Cullin
      pfam00888
      Location:14645
      Cullin; Cullin family
      pfam10557
      Location:672739
      Cullin_Nedd8; Cullin protein neddylation domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      35298728..35380758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)