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    SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2 [ Homo sapiens (human) ]

    Gene ID: 7355, updated on 24-Aug-2015
    Official Symbol
    SLC35A2provided by HGNC
    Official Full Name
    solute carrier family 35 (UDP-galactose transporter), member A2provided by HGNC
    Primary source
    HGNC:HGNC:11022
    See related
    Ensembl:ENSG00000102100; HPRD:02441; MIM:314375; Vega:OTTHUMG00000024129
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UGT; CDGX; UGAT; UGT1; UGT2; UGTL; CDG2M; UGALT; UDP-Gal-Tr
    Summary
    This gene encodes a member of the nucleotide-sugar transporter family. The encoded protein is a multi-pass membrane protein. It transports UDP-galactose from the cytosol into Golgi vesicles, where it serves as a glycosyl donor for the generation of glycans. Mutations in this gene cause congenital disorder of glycosylation type IIm (CDG2M). Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
    Orthologs
    See SLC35A2 in Epigenomics, MapViewer
    Location:
    Xp11.23-p11.22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (48903180..48911958, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48760459..48769235, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor Neighboring gene translocase of inner mitochondrial membrane 17 homolog B (yeast) Neighboring gene polyglutamine binding protein 1 Neighboring gene Pim-2 proto-oncogene, serine/threonine kinase Neighboring gene OTU deubiquitinase 5

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of solute carrier family 35 (UDP-galactose transporter), member A2 (SLC35A2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    UDP-galactose transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sugar:proton symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    UDP-galactose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    UDP-galactose transport TAS
    Traceable Author Statement
    more info
    PubMed 
    galactose metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    proton transport IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane transport TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    UDP-galactose translocator
    Names
    solute carrier family 35 (UDP-galactose transporter), member 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034300.1 RefSeqGene

      Range
      5001..13779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032289.2NP_001027460.1  UDP-galactose translocator isoform b

      See identical proteins and their annotated locations for NP_001027460.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' exon structure, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      BC035747, D84454
      Consensus CDS
      CCDS35247.1
      UniProtKB/Swiss-Prot
      P78381
      Related
      ENSP00000402726, OTTHUMP00000025815, ENST00000445167, OTTHUMT00000060792
      Conserved Domains (1) summary
      cl22888
      Location:114145
      EamA; EamA-like transporter family
    2. NM_001042498.2NP_001035963.1  UDP-galactose translocator isoform c

      See identical proteins and their annotated locations for NP_001035963.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as UGT1) differs in the 3' exon structure, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      D84454
      Consensus CDS
      CCDS43937.1
      UniProtKB/Swiss-Prot
      P78381
      Related
      ENSP00000365704, OTTHUMP00000025814, ENST00000376521, OTTHUMT00000060791
      Conserved Domains (2) summary
      TIGR00803
      Location:114338
      nst; UDP-galactose transporter
      pfam04142
      Location:96331
      Nuc_sug_transp; Nucleotide-sugar transporter
    3. NM_001282647.1NP_001269576.1  UDP-galactose translocator isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (d) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AI632201, BI820134, D84454
      Consensus CDS
      CCDS75974.1
      UniProtKB/TrEMBL
      A6NFI1
      UniProtKB/Swiss-Prot
      P78381
      Conserved Domains (1) summary
      cl22888
      Location:114145
      EamA; EamA-like transporter family
    4. NM_001282648.1NP_001269577.1  UDP-galactose translocator isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks a portion of the 5' coding region, initiates translation at an alternate upstream start codon, and differs in the 3' exon structure, compared to variant 1. The encoded isoform (e) is shorter and has distinct N- and C-termini, compared to isoform a.
      Source sequence(s)
      AL556714, D84454
      Consensus CDS
      CCDS75975.1
      UniProtKB/TrEMBL
      A6NKM8
      UniProtKB/Swiss-Prot
      P78381
      Conserved Domains (1) summary
      cl22888
      Location:90121
      EamA; EamA-like transporter family
    5. NM_001282649.1NP_001269578.1  UDP-galactose translocator isoform f

      See identical proteins and their annotated locations for NP_001269578.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon in the 5' coding region and differs in the 3' exon structure, compared to variant 1. The encoded isoform (f) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK293415, D84454
      Consensus CDS
      CCDS65253.1
      UniProtKB/Swiss-Prot
      P78381
      Related
      ENSP00000393233, ENST00000413561
      Conserved Domains (2) summary
      TIGR00803
      Location:53277
      nst; UDP-galactose transporter
      pfam04142
      Location:35270
      Nuc_sug_transp; Nucleotide-sugar transporter
    6. NM_001282650.1NP_001269579.1  UDP-galactose translocator isoform g

      See identical proteins and their annotated locations for NP_001269579.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate in-frame splice site in the 5' coding region and differs in the 3' exon structure, compared to variant 1. The encoded isoform (g) is longer and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK293419, D84454
      Consensus CDS
      CCDS75973.1
      UniProtKB/TrEMBL
      B4DE15
      UniProtKB/Swiss-Prot
      P78381
      Related
      ENSP00000478617, ENST00000616181
      Conserved Domains (2) summary
      TIGR00803
      Location:127351
      nst; UDP-galactose transporter
      pfam04142
      Location:109344
      Nuc_sug_transp; Nucleotide-sugar transporter
    7. NM_001282651.1NP_001269580.1  UDP-galactose translocator isoform h

      See identical proteins and their annotated locations for NP_001269580.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) contains an alternate in-frame exon in the 5' coding region and differs in the 3' exon structure, compared to variant 1. The encoded isoform (h) is longer and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK298484, D84454
      Consensus CDS
      CCDS65254.1
      UniProtKB/Swiss-Prot
      P78381
      Related
      ENSP00000416002, ENST00000452555
      Conserved Domains (2) summary
      TIGR00803
      Location:142366
      nst; UDP-galactose transporter
      pfam04142
      Location:124359
      Nuc_sug_transp; Nucleotide-sugar transporter
    8. NM_005660.2NP_005651.1  UDP-galactose translocator isoform a

      See identical proteins and their annotated locations for NP_005651.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as UGT2) encodes isoform a.
      Source sequence(s)
      AI632201, D84454, D88146
      Consensus CDS
      CCDS14311.1
      UniProtKB/Swiss-Prot
      P78381
      Related
      ENSP00000247138, OTTHUMP00000025813, ENST00000247138, OTTHUMT00000060790
      Conserved Domains (2) summary
      TIGR00803
      Location:114338
      nst; UDP-galactose transporter
      pfam04142
      Location:96331
      Nuc_sug_transp; Nucleotide-sugar transporter

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

      Range
      48903180..48911958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018934.2 Alternate CHM1_1.1

      Range
      48791599..48800377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)