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    KLK10 kallikrein-related peptidase 10 [ Homo sapiens (human) ]

    Gene ID: 5655, updated on 26-Jun-2015
    Official Symbol
    KLK10provided by HGNC
    Official Full Name
    kallikrein-related peptidase 10provided by HGNC
    Primary source
    HGNC:HGNC:6358
    See related
    Ensembl:ENSG00000129451; HPRD:04054; MIM:602673; Vega:OTTHUMG00000182916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NES1; PRSSL1
    Summary
    Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
    Orthologs
    See KLK10 in Epigenomics, MapViewer
    Location:
    19q13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (51012744..51020175, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51516000..51523431, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kallikrein-related peptidase 8 Neighboring gene kallikrein-related peptidase 9 Neighboring gene kallikrein-related peptidase 11 Neighboring gene kallikrein-related peptidase 12

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type peptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    kallikrein-10
    Names
    kallikrein-10
    breast normal epithelial cell associated serine protease
    kallikrein 10 protein 1
    kallikrein 10 protein 12
    kallikrein 10 protein 13
    kallikrein 10 protein 2
    kallikrein 10 protein 3
    kallikrein 10 protein 4
    kallikrein 10 protein 5
    kallikrein 10 protein 7
    kallikrein 10 protein 8
    kallikrein 10 protein 9
    normal epithelial cell-specific 1
    protease serine-like 1
    protease, serine-like, 1
    NP_001070968.1
    NP_002767.2
    NP_665895.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077500.1NP_001070968.1  kallikrein-10 preproprotein

      See identical proteins and their annotated locations for NP_001070968.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All transcript variants encode the same protein.
      Source sequence(s)
      AC011473, AY561635, BM830577, BU685208
      Consensus CDS
      CCDS12817.1
      UniProtKB/Swiss-Prot
      O43240
      Related
      ENSP00000375681, ENST00000391805
      Conserved Domains (2) summary
      smart00020
      Location:49269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. NM_002776.4NP_002767.2  kallikrein-10 preproprotein

      See identical proteins and their annotated locations for NP_002767.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All transcript variants encode the same protein.
      Source sequence(s)
      AC011473, AY561635, BC002710, BU685208
      Consensus CDS
      CCDS12817.1
      UniProtKB/Swiss-Prot
      O43240
      Related
      ENSP00000311746, OTTHUMP00000270512, ENST00000309958, OTTHUMT00000464337
      Conserved Domains (2) summary
      smart00020
      Location:49269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. NM_145888.2NP_665895.1  kallikrein-10 preproprotein

      See identical proteins and their annotated locations for NP_665895.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All transcript variants encode the same protein.
      Source sequence(s)
      AC011473, AF024605, AY561635, BU685208
      Consensus CDS
      CCDS12817.1
      UniProtKB/Swiss-Prot
      O43240
      Conserved Domains (2) summary
      smart00020
      Location:49269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

      Range
      51012744..51020175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006723288.2XP_006723351.1  

      See identical proteins and their annotated locations for XP_006723351.1

      UniProtKB/Swiss-Prot
      O43240
      Conserved Domains (2) summary
      smart00020
      Location:49269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. XM_006723289.2XP_006723352.1  

      See identical proteins and their annotated locations for XP_006723352.1

      UniProtKB/Swiss-Prot
      O43240
      Conserved Domains (2) summary
      smart00020
      Location:49269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. XM_005259061.2XP_005259118.1  

      See identical proteins and their annotated locations for XP_005259118.1

      UniProtKB/Swiss-Prot
      O43240
      Related
      ENSP00000351640, OTTHUMP00000270511, ENST00000358789, OTTHUMT00000464336
      Conserved Domains (2) summary
      smart00020
      Location:49269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    4. XM_006723287.2XP_006723350.1  

      See identical proteins and their annotated locations for XP_006723350.1

      UniProtKB/Swiss-Prot
      O43240
      Conserved Domains (2) summary
      smart00020
      Location:49269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    5. XM_005259062.2XP_005259119.1  

      See identical proteins and their annotated locations for XP_005259119.1

      UniProtKB/Swiss-Prot
      O43240
      Conserved Domains (2) summary
      smart00020
      Location:49269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      51517950..51525408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)