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    SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) [ Homo sapiens (human) ]

    Gene ID: 23020, updated on 30-Jun-2015
    Official Symbol
    SNRNP200provided by HGNC
    Official Full Name
    small nuclear ribonucleoprotein 200kDa (U5)provided by HGNC
    Primary source
    HGNC:HGNC:30859
    See related
    Ensembl:ENSG00000144028; HPRD:03391; MIM:601664; Vega:OTTHUMG00000130455
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BRR2; RP33; HELIC2; ASCC3L1; U5-200KD
    Summary
    Pre-mRNA splicing is catalyzed by the spliceosome, a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA segment. The spliceosome consists of small nuclear RNA proteins (snRNPs) U1, U2, U4, U5 and U6, together with approximately 80 conserved proteins. U5 snRNP contains nine specific proteins. This gene encodes one of the U5 snRNP-specific proteins. This protein belongs to the DEXH-box family of putative RNA helicases. It is a core component of U4/U6-U5 snRNPs and appears to catalyze an ATP-dependent unwinding of U4/U6 RNA duplices. Mutations in this gene cause autosomal-dominant retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined. [provided by RefSeq, Mar 2010]
    Orthologs
    See SNRNP200 in Epigenomics, MapViewer
    Location:
    2q11.2
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (96274336..96305569, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (96940074..96971307, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 127 Neighboring gene cytosolic iron-sulfur assembly component 1 Neighboring gene uncharacterized LOC105373495 Neighboring gene inositol 1,4,5-trisphosphate receptor interacting protein-like 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify small nuclear ribonucleoprotein 200kDa (SNRNP200), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify small nuclear ribonucleoprotein 200kDa (SNRNP200), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify small nuclear ribonucleoprotein 200kDa (SNRNP200), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify small nuclear ribonucleoprotein 200kDa (SNRNP200), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, small nuclear ribonucleoprotein 200kDa (SNRNP200), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SNRNP200 is increased by RRE PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Clone Names

    • FLJ11521

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP-dependent helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing TAS
    Traceable Author Statement
    more info
     
    cis assembly of pre-catalytic spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    gene expression TAS
    Traceable Author Statement
    more info
     
    mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    U5 snRNP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    U5 small nuclear ribonucleoprotein 200 kDa helicase
    Names
    BRR2 homolog
    U5 snRNP-specific 200 kDa protein
    activating signal cointegrator 1 complex subunit 3-like 1
    NP_054733.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016973.1 RefSeqGene

      Range
      4991..36224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_014014.4NP_054733.2  U5 small nuclear ribonucleoprotein 200 kDa helicase

      See identical proteins and their annotated locations for NP_054733.2

      Status: REVIEWED

      Source sequence(s)
      AB018331, AW190145, AY572488, BP873066, DB067751
      Consensus CDS
      CCDS2020.1
      UniProtKB/Swiss-Prot
      O75643
      Related
      ENSP00000317123, OTTHUMP00000161012, ENST00000323853, OTTHUMT00000252846
      Conserved Domains (6) summary
      smart00487
      Location:13201508
      DEXDc; DEAD-like helicases superfamily
      smart00611
      Location:18092125
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      COG1204
      Location:4521241
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cd00046
      Location:13451491
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:684870
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam02889
      Location:9821286
      Sec63; Sec63 Brl domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

      Range
      96274336..96305569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      96944413..96975645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)