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    IL24 interleukin 24 [ Homo sapiens (human) ]

    Gene ID: 11009, updated on 19-Jul-2016
    Official Symbol
    IL24provided by HGNC
    Official Full Name
    interleukin 24provided by HGNC
    Primary source
    HGNC:HGNC:11346
    See related
    Ensembl:ENSG00000162892 HPRD:04995; MIM:604136; Vega:OTTHUMG00000036459
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C49A; FISP; MDA7; MOB5; ST16; IL10B
    Summary
    This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    1q32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (206897404..206904139)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207070630..207077484)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene interleukin 20 Neighboring gene uncharacterized LOC105372879 Neighboring gene ribosomal protein L13a pseudogene 8 Neighboring gene Fc fragment of IgM receptor Neighboring gene polymeric immunoglobulin receptor

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of interleukin 24 (IL24) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • IL23-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL23-mediated signaling events, organism-specific biosystem
      IL23-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-19, 20, 22, 24, organism-specific biosystem (from REACTOME)
      Interleukin-19, 20, 22, 24, organism-specific biosystemThe interleukin-20 (IL20) subfamily comprises IL19, IL-20, IL-22, IL-24 and IL-26. They are members of the larger IL-10 family, but have been grouped together based on their usage of common receptor ...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interleukin-4 IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of JAK-STAT cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of tyrosine phosphorylation of Stat3 protein IEA
    Inferred from Electronic Annotation
    more info
     
    serine phosphorylation of STAT3 protein IEA
    Inferred from Electronic Annotation
    more info
     
    wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    interleukin-24
    Names
    IL-4-induced secreted protein
    melanocyte-associated Mda-7
    melanoma differentiation-associated gene 7 protein
    suppression of tumorigenicity 16 (melanoma differentiation)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029565.1 RefSeqGene

      Range
      5001..11697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001185156.1NP_001172085.1  interleukin-24 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001172085.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is 1 aa longer than isoform 1.
      Source sequence(s)
      AY641441, BC009681, BP222545
      Consensus CDS
      CCDS53465.1
      UniProtKB/Swiss-Prot
      Q13007
      Related
      ENSP00000375795, OTTHUMP00000034621, ENST00000391929, OTTHUMT00000088681
      Conserved Domains (1) summary
      PHA02839
      Location:74201
      PHA02839; Il-24-like protein; Provisional
    2. NM_001185157.1NP_001172086.1  interleukin-24 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001172086.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as IL-24 delE5) uses an alternate in-frame splice site in the 5' coding region, and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (4) that is shorter than isoform 1.
      Source sequence(s)
      AY641441, BP222545
      Consensus CDS
      CCDS53466.1
      UniProtKB/Swiss-Prot
      Q13007
      Related
      ENSP00000356060, OTTHUMP00000216789, ENST00000367093, OTTHUMT00000357808
    3. NM_001185158.1NP_001172087.1  interleukin-24 isoform 5

      See identical proteins and their annotated locations for NP_001172087.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as mda-7s) lacks two alternate coding exons, which results in a frameshift in the central and 3' coding regions, compared to variant 1. The encoded isoform (5, also known as MDA-7S) shares the same N-terminus but has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AY641441, BP222545, BP222651
      Consensus CDS
      CCDS73021.1
      UniProtKB/Swiss-Prot
      Q13007
      Related
      ENSP00000484900, ENST00000611909
    4. NM_006850.3NP_006841.1  interleukin-24 isoform 1 precursor

      See identical proteins and their annotated locations for NP_006841.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AY641441, BP222545, U16261
      Consensus CDS
      CCDS1471.1
      UniProtKB/Swiss-Prot
      Q13007
      Related
      ENSP00000294984, OTTHUMP00000034620, ENST00000294984, OTTHUMT00000088680
      Conserved Domains (1) summary
      PHA02839
      Location:73200
      PHA02839; Il-24-like protein; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      206897404..206904139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000121.1XP_016855610.1  

    2. XM_011509101.2XP_011507403.1  

      See identical proteins and their annotated locations for XP_011507403.1

      Conserved Domains (1) summary
      PHA02839
      Location:46173
      PHA02839; Il-24-like protein; Provisional

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      208343358..208350049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181339.1: Suppressed sequence

      Description
      NM_181339.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.