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IL16 interleukin 16 [ Homo sapiens (human) ]

Gene ID: 3603, updated on 19-Sep-2014
Official Symbol
IL16provided by HGNC
Official Full Name
interleukin 16provided by HGNC
Primary source
HGNC:HGNC:5980
See related
Ensembl:ENSG00000172349; HPRD:04329; MIM:603035; Vega:OTTHUMG00000144186
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LCF; NIL16; PRIL16; prIL-16
Summary
The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
See IL16 in Epigenomics, MapViewer
Location:
15q26.3
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 15 NC_000015.10 (81182600..81312763)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (81474941..81605104)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene acidic (leucine-rich) nuclear phosphoprotein 32 family, member B pseudogene 3 Neighboring gene chromosome 15 open reading frame 26 Neighboring gene uncharacterized LOC101929655 Neighboring gene StAR-related lipid transfer (START) domain containing 5 Neighboring gene transmembrane channel-like 3 Neighboring gene uncharacterized LOC102723985

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of interleukin 16 (IL16) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env IL-16 induces rapid translocation of PKC from the cytosol to the membrane in CD4+ cells; PKC inhibitors completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibody binding to CD4 PubMed
Tat tat Recombinant IL-16 inhibits HIV-1 Tat activation of the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ16806, FLJ42735, FLJ44234

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
immune response TAS
Traceable Author Statement
more info
PubMed 
induction of positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
leukocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
pro-interleukin-16
Names
pro-interleukin-16
prointerleukin 16
neuronal interleukin 16
lymphocyte chemoattractant factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029933.1 

    Range
    5001..120886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001172128.1NP_001165599.1  pro-interleukin-16 isoform 3

    See proteins identical to NP_001165599.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is longer, compared to isoform 1.
    Source sequence(s)
    AC103858, AK124725, AK131530
    Consensus CDS
    CCDS53966.1
    UniProtKB/Swiss-Prot
    Q14005
    Related
    ENSP00000378155, OTTHUMP00000185571, ENST00000394660, OTTHUMT00000291391
    Conserved Domains (2) summary
    cd00992
    Location:217300
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl09133
    Location:860955
    COG1615; Uncharacterized conserved protein [Function unknown]
  2. NM_004513.5NP_004504.3  pro-interleukin-16 isoform 1

    See proteins identical to NP_004504.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AC103858, DB141707, U82972
    Consensus CDS
    CCDS10317.1
    UniProtKB/Swiss-Prot
    Q14005
    UniProtKB/TrEMBL
    Q9UME6
    Conserved Domains (2) summary
    cd00992
    Location:410487
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl09133
    Location:159254
    COG1615; Uncharacterized conserved protein [Function unknown]
  3. NM_172217.3NP_757366.2  pro-interleukin-16 isoform 2

    See proteins identical to NP_757366.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and and 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is longer at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC103858, AK124725, AY324389
    Consensus CDS
    CCDS42069.1
    UniProtKB/Swiss-Prot
    Q14005
    Conserved Domains (2) summary
    cd00992
    Location:217300
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl09133
    Location:860955
    COG1615; Uncharacterized conserved protein [Function unknown]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000015.10 

    Range
    81182600..81312763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254342.2XP_005254399.1  

    Related
    ENSP00000302935, OTTHUMP00000190850, ENST00000302987, OTTHUMT00000303952
    Conserved Domains (2) summary
    cd00992
    Location:264347
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl09133
    Location:9071002
    COG1615; Uncharacterized conserved protein [Function unknown]
  2. XM_005254343.2XP_005254400.1  

    Conserved Domains (2) summary
    cd00992
    Location:264347
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl09133
    Location:9071002
    COG1615; Uncharacterized conserved protein [Function unknown]
  3. XM_005254344.2XP_005254401.1  

    Conserved Domains (2) summary
    cd00992
    Location:501578
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl09133
    Location:250345
    COG1615; Uncharacterized conserved protein [Function unknown]
  4. XM_005254345.2XP_005254402.1  

    Conserved Domains (2) summary
    cd00992
    Location:501578
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl09133
    Location:250345
    COG1615; Uncharacterized conserved protein [Function unknown]
  5. XM_005254346.2XP_005254403.1  

    See proteins identical to XP_005254403.1

    UniProtKB/Swiss-Prot
    Q14005
    Related
    ENSP00000378147, OTTHUMP00000190849, ENST00000394652, OTTHUMT00000303951
    Conserved Domains (2) summary
    cd00992
    Location:410487
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl09133
    Location:159254
    COG1615; Uncharacterized conserved protein [Function unknown]

RNA

  1. XR_429452.1 RNA Sequence

Alternate HuRef

Genomic

  1. AC_000147.1 

    Range
    58247361..58363403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 

    Range
    81607068..81723070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)