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ADRBK2 adrenergic, beta, receptor kinase 2 [ Homo sapiens (human) ]

Gene ID: 157, updated on 11-Sep-2014
Official Symbol
ADRBK2provided by HGNC
Official Full Name
adrenergic, beta, receptor kinase 2provided by HGNC
Primary source
HGNC:HGNC:290
See related
Ensembl:ENSG00000100077; HPRD:00183; MIM:109636; Vega:OTTHUMG00000150280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRK3; BARK2
Summary
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]
See ADRBK2 in Epigenomics, MapViewer
Location:
22q12.1
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 22 NC_000022.11 (25564894..25729294)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (25960861..26125259)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene crystallin, beta B2 pseudogene 1 Neighboring gene microRNA 6817 Neighboring gene uncharacterized LOC100996404 Neighboring gene YES1 pseudogene 1 Neighboring gene RNA, 5S ribosomal pseudogene 494 Neighboring gene myosin XVIIIB Neighboring gene uncharacterized LOC102724801

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
    Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Corticotropin-releasing hormone, organism-specific biosystem (from WikiPathways)
    Corticotropin-releasing hormone, organism-specific biosystemCorticotropin-releasing hormone (CRH) is a neuropeptide secreted abundantly in the paraventricular nucleus of the hypothalamus, amygdala, cerebral cortex and cerebellum in the central nervous system ...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Glutamatergic synapse, organism-specific biosystem (from KEGG)
    Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Glutamatergic synapse, conserved biosystem (from KEGG)
    Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • IL-4 signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-4 signaling Pathway, organism-specific biosystemInterleukin-4 belongs to the IL-2 family of cytokines, which includes IL-2, IL-7, IL-9, IL-15 and IL-21. It signals through 2 different receptor complexes; Receptor complex 1 comprises of IL-4 recept...
  • Morphine addiction, organism-specific biosystem (from KEGG)
    Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Morphine addiction, conserved biosystem (from KEGG)
    Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Olfactory transduction, organism-specific biosystem (from KEGG)
    Olfactory transduction, organism-specific biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
  • Olfactory transduction, conserved biosystem (from KEGG)
    Olfactory transduction, conserved biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
  • Thromboxane A2 receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    Thromboxane A2 receptor signaling, organism-specific biosystem
    Thromboxane A2 receptor signaling
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
G-protein coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
 
beta-adrenergic receptor kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
receptor internalization IDA
Inferred from Direct Assay
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
termination of G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
beta-adrenergic receptor kinase 2
Names
beta-adrenergic receptor kinase 2
beta-ARK-2
G-protein-coupled receptor kinase 3
NP_005151.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005160.3NP_005151.2  beta-adrenergic receptor kinase 2

    See proteins identical to NP_005151.2

    Status: REVIEWED

    Source sequence(s)
    AL022329, BC036797, BC063545, BX387339
    Consensus CDS
    CCDS13832.1
    UniProtKB/TrEMBL
    A0A024R1D8
    UniProtKB/Swiss-Prot
    P35626
    UniProtKB/TrEMBL
    Q8N433
    Related
    ENSP00000317578, OTTHUMP00000196857, ENST00000324198, OTTHUMT00000317296
    Conserved Domains (5) summary
    cd05606
    Location:196473
    STKc_beta_ARK; Catalytic domain of the Protein Serine/Threonine Kinase, beta-adrenergic receptor kinase
    cd08747
    Location:30186
    RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
    smart00133
    Location:454520
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd01240
    Location:553670
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    pfam00069
    Location:191453
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000022.11 

    Range
    25564894..25729294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724158.1XP_006724221.1  

    See proteins identical to XP_006724221.1

    Conserved Domains (5) summary
    cd05606
    Location:83360
    STKc_beta_ARK; Catalytic domain of the Protein Serine/Threonine Kinase, beta-adrenergic receptor kinase
    smart00133
    Location:341407
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd01240
    Location:440557
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    pfam00069
    Location:78340
    Pkinase; Protein kinase domain
    cl02565
    Location:173
    RGS; Regulator of G protein signaling (RGS) domain superfamily

Alternate HuRef

Genomic

  1. AC_000154.1 

    Range
    8948071..9073051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 

    Range
    25919893..26084649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)