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FYN FYN proto-oncogene, Src family tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 2534, updated on 26-Aug-2014
Official Symbol
FYNprovided by HGNC
Official Full Name
FYN proto-oncogene, Src family tyrosine kinaseprovided by HGNC
Primary source
HGNC:4037
Locus tag
RP1-66H14.1
See related
Ensembl:ENSG00000010810; HPRD:00655; MIM:137025; Vega:OTTHUMG00000016305
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLK; SYN; p59-FYN
Summary
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]
Location:
6q21
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (111660332..111873452, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (111981535..112194655, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TRAF3IP2 antisense RNA 1 Neighboring gene uncharacterized LOC100996652 Neighboring gene TRAF3 interacting protein 2 Neighboring gene small nuclear ribonucleoprotein-associated protein B'-like Neighboring gene uncharacterized LOC102724646 Neighboring gene WNT1 inducible signaling pathway protein 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tyrosine kinase Fyn-mediated phosphorylation of IFITM3 at position Y20 induces localization of IFITM3 at the endocytic compartments, which impairs inhibition of Env-mediated entry by IFITM3 delta(1-21) mutant PubMed
env Interaction of HIV-1 gp120 with CD4 leads to increased levels of phosphorylation of the src-family Lck and Fyn protein tyrosine kinases and enhancement of their activities PubMed
Envelope surface glycoprotein gp160, precursor env Pretreatment of cells with HIV-1 gp160 results in marked inhibition of tyrosine phosphorylation of p59(fyn), PLC-gamma1, ras activation, and TNF-alpha secretion in anti-CD3 mAb activated CD4+ T cells PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp120 and gp41-induced cell killing is accompanied by tyrosine phosphorylation and activation of the CD4-associated p56(Lck) kinase, and by activation of a second member of the scr family of protein tyrosine kinases, p59(fyn) kinase PubMed
Nef nef The single amino acid residue number 96 in the SH3 domain of Fyn regulates its affinity and specificity in binding to HIV-1 Nef PubMed
nef Crystal structure studies reveal the conserved PXXP sequence motif of HIV-1 Nef is part of a polyproline type II helix that is required for Nef binding to the SH3 domain of Fyn PubMed
nef HIV-1 Nef binds to the SH3 domain of Fyn through its proline-rich (PXXP) motifs between amino acid residues 65 and 82; this binding enhances viral replication but not down-regulation of CD4 PubMed
Pr55(Gag) gag Fyn enhances HIV-1 Gag assembly and release in T cells PubMed

Go to the HIV-1, Human Protein Interaction Database

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  • ErbB4 signaling events, organism-specific biosystem (from Pathway Interaction Database)
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    Nephrin/Neph1 signaling in the kidney podocyte
  • Netrin mediated repulsion signals, organism-specific biosystem (from REACTOME)
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  • Netrin-1 signaling, organism-specific biosystem (from REACTOME)
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  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
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  • Osteoclast differentiation, conserved biosystem (from KEGG)
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  • PDGFR-beta signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    PDGFR-beta signaling pathway, organism-specific biosystem
    PDGFR-beta signaling pathway
  • PECAM1 interactions, organism-specific biosystem (from REACTOME)
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  • PI-3K cascade, organism-specific biosystem (from REACTOME)
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  • PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
    PI3K events in ERBB2 signaling, organism-specific biosystemERBB2:ERBB3 and ERBB2:ERBB4cyt1 heterodimers activate PI3K signaling by direct binding of PI3K regulatory subunit p85 (Yang et al. 2007, Cohen et al. 1996, Kaushansky et al. 2008) to phosphorylated t...
  • PI3K events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
    PI3K events in ERBB4 signaling, organism-specific biosystemThe CYT1 isoforms of ERBB4 possess a C-tail tyrosine residue that, upon trans-autophosphorylation, serves as a docking site for the p85 alpha subunit of PI3K - PIK3R1 (Kaushansky et al. 2008, Cohen e...
  • PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
    PI3K/AKT Signaling in Cancer, organism-specific biosystemThis pathway describes how normal signaling by PI3K/AKT, presented in the contained module 'PIP3 Activates AKT Signaling' and recently reviewed by Manning and Cantley in 2007, is perturbed in cancer,...
  • PI3K/AKT activation, organism-specific biosystem (from REACTOME)
    PI3K/AKT activation, organism-specific biosystemPI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell...
  • PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
    PIP3 activates AKT signaling, organism-specific biosystemSignaling by AKT is one of the key outcomes of receptor tyrosine kinase (RTK) activation. AKT is activated by the cellular second messenger PIP3, a phospholipid that is generated by PI3K. In ustimula...
  • Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
    Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
  • Pathogenic Escherichia coli infection, organism-specific biosystem (from WikiPathways)
    Pathogenic Escherichia coli infection, organism-specific biosystemSources: [http://www.genome.jp/kegg/pathway/hsa/hsa05130.html KEGG]
  • Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
    Pathogenic Escherichia coli infection, conserved biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
  • Platelet Adhesion to exposed collagen, organism-specific biosystem (from REACTOME)
    Platelet Adhesion to exposed collagen, organism-specific biosystemInitiation of platelet adhesion is the first step in the formation of the platelet plug. Circulating platelets are arrested and subsequently activated by exposed collagen and vWF. It is not entirely ...
  • Platelet activation, organism-specific biosystem (from KEGG)
    Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Prion diseases, organism-specific biosystem (from KEGG)
    Prion diseases, organism-specific biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
  • Prion diseases, conserved biosystem (from KEGG)
    Prion diseases, conserved biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
  • Prolactin Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Prolactin Signaling Pathway, organism-specific biosystemProlactin (PRL), a pleiotropic polypeptide hormone, mostly secreted by the lactotrophic cells of anterior pituitary gland and to a lesser extent expressed in numerous extra pituitary tissues such as ...
  • Reelin signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    Reelin signaling pathway, organism-specific biosystem
    Reelin signaling pathway
  • Regulation of KIT signaling, organism-specific biosystem (from REACTOME)
    Regulation of KIT signaling, organism-specific biosystemSCF induced proliferation is negatively regulated by various proteins including SHP1, PKC, CBL, SOCS1, SOCS6 and LNK.
  • Regulation of p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of p38-alpha and p38-beta, organism-specific biosystem
    Regulation of p38-alpha and p38-beta
  • Regulation of signaling by CBL, organism-specific biosystem (from REACTOME)
    Regulation of signaling by CBL, organism-specific biosystemCbl is an E3 ubiquitin-protein ligase that negatively regulates signaling pathways by targeting proteins for ubiquitination and proteasomal degradation (Rao et al. 2002). Cbl negatively regulates PI3...
  • Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystem (from REACTOME)
    Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystemThe lipid raft resident adaptor molecules LAT1 and Non-T cell activation linker (NTAL), also known as linker for activation of B cells (LAB)/LAT2 are known participants in the regulation of mast cell...
  • SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion, organism-specific biosystem (from REACTOME)
    SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion, organism-specific biosystemSema3A, a prototypical semaphorin, acts as a chemorepellent or a chemoattractant for axons by activating a receptor complex comprising neuropilin-1 as the ligand-binding subunit and plexin-A1 as the ...
  • Sema3A PAK dependent Axon repulsion, organism-specific biosystem (from REACTOME)
    Sema3A PAK dependent Axon repulsion, organism-specific biosystemActivated Rac1 bound to plexin-A might modulate actin dynamics through the sequential phosphorylation and activation of PAK, LIMK1 and cofilin.
  • Semaphorin interactions, organism-specific biosystem (from REACTOME)
    Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by EGFR, organism-specific biosystem (from REACTOME)
    Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
  • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
    Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in parallel with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...
  • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
    Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
  • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
    Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
  • Signaling by FGFR, organism-specific biosystem (from REACTOME)
    Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
    Signaling by FGFR in disease, organism-specific biosystemThe pathway 'Signaling by FGFR in disease' shows 'Signaling by FGFR mutants' in parallel with the wild-type pathway 'Signaling by FGFR', allowing users to compare disease and normal events. FGFR mut...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Signaling by PDGF, organism-specific biosystem (from REACTOME)
    Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
  • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
    Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
  • Signaling by VEGF, organism-specific biosystem (from REACTOME)
    Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
  • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
    Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
  • Signaling events mediated by PTP1B, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by PTP1B, organism-specific biosystem
    Signaling events mediated by PTP1B
  • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
    Signaling events mediated by VEGFR1 and VEGFR2
  • Signaling events mediated by focal adhesion kinase, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by focal adhesion kinase, organism-specific biosystem
    Signaling events mediated by focal adhesion kinase
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • Syndecan-3-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    Syndecan-3-mediated signaling events, organism-specific biosystem
    Syndecan-3-mediated signaling events
  • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
    T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • T cell receptor signaling pathway, conserved biosystem (from KEGG)
    T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • TCR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TCR Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
  • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
    TCR signaling in naive CD4+ T cells, organism-specific biosystem
    TCR signaling in naive CD4+ T cells
  • TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
    TCR signaling in naive CD8+ T cells, organism-specific biosystem
    TCR signaling in naive CD8+ T cells
  • The role of Nef in HIV-1 replication and disease pathogenesis, organism-specific biosystem (from REACTOME)
    The role of Nef in HIV-1 replication and disease pathogenesis, organism-specific biosystemThe HIV-1 Nef protein is a 27-kDa myristoylated protein that is abundantly produced during the early phase of viral replication cycle. It is highly conserved in all primate lentiviruses, suggesting t...
  • Thromboxane A2 receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    Thromboxane A2 receptor signaling, organism-specific biosystem
    Thromboxane A2 receptor signaling
  • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
    VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
  • Viral myocarditis, organism-specific biosystem (from KEGG)
    Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
  • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
    amb2 Integrin signaling, organism-specific biosystem
    amb2 Integrin signaling
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC45350

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
CD4 receptor binding IEA
Inferred from Electronic Annotation
more info
 
CD8 receptor binding IEA
Inferred from Electronic Annotation
more info
 
T cell receptor binding IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
glycoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ion channel binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
peptide hormone receptor binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity EXP
Inferred from Experiment
more info
 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
tubulin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
T cell costimulation TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
activated T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
calcium ion transport NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to peptide hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
detection of mechanical stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
feeding behavior TAS
Traceable Author Statement
more info
PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
learning TAS
Traceable Author Statement
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of defense response to virus by virus TAS
Traceable Author Statement
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
viral process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tyrosine-protein kinase Fyn
Names
tyrosine-protein kinase Fyn
src-like kinase
proto-oncogene Syn
c-syn protooncogene
proto-oncogene c-Fyn
src/yes-related novel
tyrosine kinase p59fyn(T)
FYN oncogene related to SRC, FGR, YES
OKT3-induced calcium influx regulator
NP_002028.1
NP_694592.1
NP_694593.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002037.5NP_002028.1  tyrosine-protein kinase Fyn isoform a

    See proteins identical to NP_002028.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BP391373, DA570412, M14333, Z97989
    Consensus CDS
    CCDS5094.1
    UniProtKB/Swiss-Prot
    P06241
    Related
    ENSP00000346671, OTTHUMP00000017914, ENST00000354650, OTTHUMT00000043655
    Conserved Domains (4) summary
    cd05070
    Location:264523
    Blast Score: 1547
    PTKc_Fyn_Yrk; Catalytic domain of the Protein Tyrosine Kinases, Fyn and Yrk
    cd10418
    Location:145245
    Blast Score: 602
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85140
    Blast Score: 328
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    pfam07714
    Location:271520
    Blast Score: 1073
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_153047.3NP_694592.1  tyrosine-protein kinase Fyn isoform b

    See proteins identical to NP_694592.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and lacks an alternate in-frame exon but includes a different in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    BC032496, BP391373, S74774, Z97989
    Consensus CDS
    CCDS5095.1
    UniProtKB/Swiss-Prot
    P06241
    Related
    ENSP00000440646, ENST00000538466
    Conserved Domains (4) summary
    cd10368
    Location:145245
    Blast Score: 585
    SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
    cd12006
    Location:85140
    Blast Score: 326
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    pfam07714
    Location:268517
    Blast Score: 1070
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:261520
    Blast Score: 1514
    PKc_like; Protein Kinases, catalytic domain
  3. NM_153048.3NP_694593.1  tyrosine-protein kinase Fyn isoform c

    See proteins identical to NP_694593.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    BC032496, BP391373, DA815564, Z97989
    Consensus CDS
    CCDS5096.1
    UniProtKB/Swiss-Prot
    P06241
    Conserved Domains (4) summary
    cd10368
    Location:145245
    Blast Score: 573
    SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
    cd12006
    Location:85140
    Blast Score: 325
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    pfam07714
    Location:231465
    Blast Score: 1008
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:205468
    Blast Score: 1407
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    111660332..111873452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266892.1XP_005266949.1  

    See proteins identical to XP_005266949.1

    UniProtKB/Swiss-Prot
    P06241
    Conserved Domains (4) summary
    cd10368
    Location:145245
    Blast Score: 573
    SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
    cd12006
    Location:85140
    Blast Score: 325
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    pfam07714
    Location:231465
    Blast Score: 1008
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:205468
    Blast Score: 1407
    PKc_like; Protein Kinases, catalytic domain
  2. XM_005266890.1XP_005266947.1  

    See proteins identical to XP_005266947.1

    UniProtKB/Swiss-Prot
    P06241
    Related
    ENSP00000357671, OTTHUMP00000017915, ENST00000368682, OTTHUMT00000043656
    Conserved Domains (4) summary
    cd10368
    Location:145245
    Blast Score: 585
    SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
    cd12006
    Location:85140
    Blast Score: 326
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    pfam07714
    Location:268517
    Blast Score: 1070
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:261520
    Blast Score: 1514
    PKc_like; Protein Kinases, catalytic domain
  3. XM_005266887.1XP_005266944.1  

    See proteins identical to XP_005266944.1

    UniProtKB/Swiss-Prot
    P06241
    Conserved Domains (4) summary
    cd05070
    Location:264523
    Blast Score: 1547
    PTKc_Fyn_Yrk; Catalytic domain of the Protein Tyrosine Kinases, Fyn and Yrk
    cd10418
    Location:145245
    Blast Score: 602
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85140
    Blast Score: 328
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    pfam07714
    Location:271520
    Blast Score: 1073
    Pkinase_Tyr; Protein tyrosine kinase
  4. XM_006715429.1XP_006715492.1  

    See proteins identical to XP_006715492.1

    UniProtKB/Swiss-Prot
    P06241
    Conserved Domains (4) summary
    cd05070
    Location:264523
    Blast Score: 1547
    PTKc_Fyn_Yrk; Catalytic domain of the Protein Tyrosine Kinases, Fyn and Yrk
    cd10418
    Location:145245
    Blast Score: 602
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85140
    Blast Score: 328
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    pfam07714
    Location:271520
    Blast Score: 1073
    Pkinase_Tyr; Protein tyrosine kinase
  5. XM_005266889.1XP_005266946.1  

    See proteins identical to XP_005266946.1

    UniProtKB/Swiss-Prot
    P06241
    Conserved Domains (4) summary
    cd05070
    Location:264523
    Blast Score: 1547
    PTKc_Fyn_Yrk; Catalytic domain of the Protein Tyrosine Kinases, Fyn and Yrk
    cd10418
    Location:145245
    Blast Score: 602
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85140
    Blast Score: 328
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    pfam07714
    Location:271520
    Blast Score: 1073
    Pkinase_Tyr; Protein tyrosine kinase
  6. XM_005266888.1XP_005266945.1  

    See proteins identical to XP_005266945.1

    UniProtKB/Swiss-Prot
    P06241
    Conserved Domains (4) summary
    cd05070
    Location:264523
    Blast Score: 1547
    PTKc_Fyn_Yrk; Catalytic domain of the Protein Tyrosine Kinases, Fyn and Yrk
    cd10418
    Location:145245
    Blast Score: 602
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85140
    Blast Score: 328
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    pfam07714
    Location:271520
    Blast Score: 1073
    Pkinase_Tyr; Protein tyrosine kinase

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    109554123..109767060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    112244349..112457405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001242779.1: Suppressed sequence

    Description
    NM_001242779.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.