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    WNT3 wingless-type MMTV integration site family, member 3 [ Homo sapiens (human) ]

    Gene ID: 7473, updated on 4-Jul-2015
    Official Symbol
    WNT3provided by HGNC
    Official Full Name
    wingless-type MMTV integration site family, member 3provided by HGNC
    Primary source
    HGNC:HGNC:12782
    See related
    Ensembl:ENSG00000108379; HPRD:01318; MIM:165330; Vega:OTTHUMG00000178076
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    INT4; TETAMS
    Summary
    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]
    Orthologs
    See WNT3 in Epigenomics, MapViewer
    Location:
    17q21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (46762506..46818760, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (44839872..44896126, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like 17A Neighboring gene leucine rich repeat containing 37, member A2 Neighboring gene N-ethylmaleimide-sensitive factor Neighboring gene ribosomal protein S7 pseudogene 11 Neighboring gene uncharacterized LOC101929777 Neighboring gene wingless-type MMTV integration site family, member 9B

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Tetraamelia, autosomal recessive
    MedGen: C2749279 OMIM: 273395 GeneReviews: Tetra-Amelia Syndrome
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population.
    NHGRI GWA Catalog
    Identification of a novel Parkinson's disease locus via stratified genome-wide association study.
    NHGRI GWA Catalog
    Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
    NHGRI GWA Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    NHGRI GWA Catalog
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC131950, MGC138321, MGC138323

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    frizzled binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    receptor agonist activity IC
    Inferred by Curator
    more info
    PubMed 
    Process Evidence Code Pubs
    Spemann organizer formation at the anterior end of the primitive streak IEA
    Inferred from Electronic Annotation
    more info
     
    anterior/posterior axis specification IEA
    Inferred from Electronic Annotation
    more info
     
    axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway involved in osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to retinoic acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dorsal/ventral axis specification IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic forelimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic hindlimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    gamete generation IEA
    Inferred from Electronic Annotation
    more info
     
    head morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    limb bud formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mammary gland epithelium development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    mesoderm formation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of axon extension involved in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of collateral sprouting in absence of injury IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi lumen TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    proto-oncogene Wnt-3
    Names
    WNT-3 proto-oncogene protein
    proto-oncogene Int-4 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008084.2 RefSeqGene

      Range
      4957..61211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_030753.4NP_110380.1  proto-oncogene Wnt-3 precursor

      See identical proteins and their annotated locations for NP_110380.1

      Status: REVIEWED

      Source sequence(s)
      BC114219, CX872929, DB462855
      Consensus CDS
      CCDS11505.1
      UniProtKB/Swiss-Prot
      P56703
      Related
      ENSP00000225512, OTTHUMP00000258452, ENST00000225512, OTTHUMT00000440427
      Conserved Domains (1) summary
      smart00097
      Location:47355
      WNT1; found in Wnt-1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

      Range
      46762506..46818760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p2 ALT_REF_LOCI_1

    Genomic

    1. NT_167251.2 Reference GRCh38.p2 ALT_REF_LOCI_1

      Range
      1748384..1804487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p2 ALT_REF_LOCI_2

    Genomic

    1. NT_187663.1 Reference GRCh38.p2 ALT_REF_LOCI_2

      Range
      1281918..1338200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      44903996..44960278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)