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    CRH corticotropin releasing hormone [ Homo sapiens (human) ]

    Gene ID: 1392, updated on 3-Apr-2016
    Official Symbol
    CRHprovided by HGNC
    Official Full Name
    corticotropin releasing hormoneprovided by HGNC
    Primary source
    HGNC:HGNC:2355
    See related
    Ensembl:ENSG00000147571 HPRD:07172; MIM:122560; Vega:OTTHUMG00000164474
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRF; CRH1
    Summary
    This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015]
    Orthologs
    Location:
    8q13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (66176377..66178611, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (67088612..67090846, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene transfer RNA-Tyr (GTA) 5-2 Neighboring gene tripartite motif containing 55 Neighboring gene uncharacterized LOC101929722 Neighboring gene uncharacterized LOC102724687 Neighboring gene long intergenic non-protein coding RNA 967 Neighboring gene RRS1 antisense RNA 1 (head to head)

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy.
    NHGRI GWA Catalog
    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
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    • Corticotropin-releasing hormone, organism-specific biosystem (from WikiPathways)
      Corticotropin-releasing hormone, organism-specific biosystemCorticotropin-releasing hormone (CRH) is a neuropeptide secreted abundantly in the paraventricular nucleus of the hypothalamus, amygdala, cerebral cortex and cerebellum in the central nervous system ...
    • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    corticotropin-releasing hormone receptor 1 binding IEA
    Inferred from Electronic Annotation
    more info
     
    corticotropin-releasing hormone receptor 2 binding IEA
    Inferred from Electronic Annotation
    more info
     
    hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    neuropeptide hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    adrenal gland development IEA
    Inferred from Electronic Annotation
    more info
     
    associative learning IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to dexamethasone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    diterpenoid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    female pregnancy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucocorticoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    hormone-mediated apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    hypothalamus development IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    learning or memory TAS
    Traceable Author Statement
    more info
    PubMed 
    locomotory exploration behavior IEA
    Inferred from Electronic Annotation
    more info
     
    long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    lung development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell death IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of circadian sleep/wake cycle, REM sleep NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of epinephrine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of glucagon secretion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of luteinizing hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of norepinephrine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    parturition TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cAMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of calcium ion import IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell death IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of circadian sleep/wake cycle, wakefulness NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of corticosterone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of corticotropin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cortisol secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of digestive system process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of N-methyl-D-aspartate selective glutamate receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of serotonin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    response to corticosterone IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to estrogen IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to ether IEA
    Inferred from Electronic Annotation
    more info
     
    response to immobilization stress IEA
    Inferred from Electronic Annotation
    more info
     
    response to pain IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    synaptic transmission TAS
    Traceable Author Statement
    more info
    PubMed 
    synaptic transmission, dopaminergic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    varicosity IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    corticoliberin
    Names
    corticotropin-releasing factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016127.1 RefSeqGene

      Range
      4819..7087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000756.3NP_000747.1  corticoliberin preproprotein

      See identical proteins and their annotated locations for NP_000747.1

      Status: REVIEWED

      Source sequence(s)
      AK075431, CB992265
      Consensus CDS
      CCDS6188.1
      UniProtKB/Swiss-Prot
      P06850
      UniProtKB/TrEMBL
      A0A0S2Z478
      Related
      ENSP00000276571, OTTHUMP00000226787, ENST00000276571, OTTHUMT00000378926
      Conserved Domains (1) summary
      smart00039
      Location:155194
      CRF; corticotropin-releasing factor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

      Range
      66176377..66178611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      67143265..67145499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)