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FGFR3 fibroblast growth factor receptor 3 [ Homo sapiens (human) ]

Gene ID: 2261, updated on 11-Sep-2014
Official Symbol
FGFR3provided by HGNC
Official Full Name
fibroblast growth factor receptor 3provided by HGNC
Primary source
HGNC:HGNC:3690
See related
Ensembl:ENSG00000068078; HPRD:00624; MIM:134934; Vega:OTTHUMG00000121148
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACH; CEK2; JTK4; CD333; HSFGFR3EX
Summary
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009]
See FGFR3 in Epigenomics, MapViewer
Location:
4p16.3
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 4 NC_000004.12 (1793299..1808872)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (1795039..1810599)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 129, E3 ubiquitin protein ligase Neighboring gene transforming, acidic coiled-coil containing protein 3 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 1 Neighboring gene Wolf-Hirschhorn syndrome candidate 1 Neighboring gene small Cajal body-specific RNA 22

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Achondroplasia
MedGen: C0001080 OMIM: 100800 GeneReviews: Achondroplasia
Compare labs
Camptodactyly, tall stature, and hearing loss syndrome
MedGen: C1864852 OMIM: 610474 GeneReviews: Not available
Compare labs
Carcinoma of cervix
MedGen: C0302592 OMIM: 603956 GeneReviews: Not available
Compare labs
Crouzon syndrome with acanthosis nigricans Compare labs
Epidermal nevus
MedGen: C0334082 OMIM: 162900 GeneReviews: Not available
Compare labs
Hypochondroplasia
MedGen: C0410529 OMIM: 146000 GeneReviews: Hypochondroplasia
Compare labs
Isolated coronal synostosis Compare labs
Levy-Hollister syndrome
MedGen: C0265269 OMIM: 149730 GeneReviews: Not available
Compare labs
Malignant tumor of testis
MedGen: C0153594 OMIM: 273300 GeneReviews: Not available
Compare labs
Malignant tumor of urinary bladder
MedGen: C0005684 OMIM: 109800 GeneReviews: Not available
Compare labs
Muenke syndrome Compare labs
Thanatophoric dysplasia type 1
MedGen: C1868678 OMIM: 187600 GeneReviews: Thanatophoric Dysplasia
Compare labs
Thanatophoric dysplasia, type 2
MedGen: C1300257 OMIM: 187601 GeneReviews: Thanatophoric Dysplasia
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2011-11-09)

ISCA Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2011-11-09)

ISCA Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
NHGRI GWA Catalog
A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.
NHGRI GWA Catalog
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
NHGRI GWA Catalog
  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
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  • Bladder cancer, organism-specific biosystem (from KEGG)
    Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
  • Bladder cancer, conserved biosystem (from KEGG)
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    Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
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    Downstream signaling events of B Cell Receptor (BCR), organism-specific biosystemSecond messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RA...
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    Downstream signaling of activated FGFR, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
  • Endochondral Ossification, organism-specific biosystem (from WikiPathways)
    Endochondral Ossification, organism-specific biosystem
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    FGFR ligand binding and activation, organism-specific biosystemThe FGFs are a family of 22 secreted glycoproteins that are sequestered in the extracellular matrix (ECM) through their interaction with heparin and heparin sulphate proteoglycans (HSPGs). Release o...
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    FGFR3 ligand binding and activation, organism-specific biosystemFGFR3 is a receptor tyrosine kinase of the FGF receptor family, known to have a negative regulatory effect on long bone growth. Somatically, some of the same activating mutations are associated with ...
  • FGFR3b ligand binding and activation, organism-specific biosystem (from REACTOME)
    FGFR3b ligand binding and activation, organism-specific biosystemThis pathway depicts the binding of an experimentally-verified range of ligands to FGFR3b. While binding affinities may vary considerably within this set, the ligands listed have been established to ...
  • FGFR3c ligand binding and activation, organism-specific biosystem (from REACTOME)
    FGFR3c ligand binding and activation, organism-specific biosystemThis pathway depicts the binding of an experimentally-verified range of ligands to FGFR3c. While binding affinities may vary considerably within this set, the ligands listed have been established to ...
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    FRS2-mediated cascade, organism-specific biosystemThe FRS family of scaffolding adaptor proteins has two members, FRS2alpha and FRS2beta (also known as FRS3 or SNT-2). Activation of FGFR tyrosine kinase allows FRS2 proteins to become phosphorylated...
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    GAB1 signalosome, organism-specific biosystemGAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also...
  • IGF1R signaling cascade, organism-specific biosystem (from REACTOME)
    IGF1R signaling cascade, organism-specific biosystemAfter autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activ...
  • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
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    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
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    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
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    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
    NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
  • Negative regulation of FGFR signaling, organism-specific biosystem (from REACTOME)
    Negative regulation of FGFR signaling, organism-specific biosystemOnce activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-m...
  • Neural Crest Differentiation, organism-specific biosystem (from WikiPathways)
    Neural Crest Differentiation, organism-specific biosystemGene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involv...
  • PI-3K cascade, organism-specific biosystem (from REACTOME)
    PI-3K cascade, organism-specific biosystemThe ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which i...
  • PI3K Cascade, organism-specific biosystem (from REACTOME)
    PI3K Cascade, organism-specific biosystem
    PI3K Cascade
  • PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
    PI3K events in ERBB2 signaling, organism-specific biosystemERBB2:ERBB3 and ERBB2:ERBB4cyt1 heterodimers activate PI3K signaling by direct binding of PI3K regulatory subunit p85 (Yang et al. 2007, Cohen et al. 1996, Kaushansky et al. 2008) to phosphorylated t...
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    PI3K events in ERBB4 signaling, organism-specific biosystemThe CYT1 isoforms of ERBB4 possess a C-tail tyrosine residue that, upon trans-autophosphorylation, serves as a docking site for the p85 alpha subunit of PI3K - PIK3R1 (Kaushansky et al. 2008, Cohen e...
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  • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
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  • t(4;14) translocations of FGFR3, organism-specific biosystem (from REACTOME)
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
fibroblast growth factor-activated receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
JAK-STAT cascade TAS
Traceable Author Statement
more info
PubMed 
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
alveolar secondary septum development IEA
Inferred from Electronic Annotation
more info
 
axonogenesis involved in innervation IEA
Inferred from Electronic Annotation
more info
 
bone maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
bone morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
bone morphogenesis TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling IEA
Inferred from Electronic Annotation
more info
 
central nervous system myelination IEA
Inferred from Electronic Annotation
more info
 
chondrocyte differentiation TAS
Traceable Author Statement
more info
PubMed 
chondrocyte proliferation TAS
Traceable Author Statement
more info
PubMed 
cochlea development IEA
Inferred from Electronic Annotation
more info
 
digestive tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
endochondral bone growth TAS
Traceable Author Statement
more info
PubMed 
endochondral ossification TAS
Traceable Author Statement
more info
PubMed 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
epithelial cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor receptor apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
inner ear receptor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway TAS
Traceable Author Statement
more info
 
lens fiber cell development IEA
Inferred from Electronic Annotation
more info
 
lens morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
morphogenesis of an epithelium IEA
Inferred from Electronic Annotation
more info
 
negative regulation of astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of developmental growth ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitosis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of phospholipase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of Stat1 protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tyrosine phosphorylation of Stat3 protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
response to axon injury IEA
Inferred from Electronic Annotation
more info
 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
somatic stem cell maintenance IEA
Inferred from Electronic Annotation
more info
 
substantia nigra development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic membrane-bounded vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with focal adhesion TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
fibroblast growth factor receptor 3
Names
fibroblast growth factor receptor 3
FGFR-3
tyrosine kinase JTK4
hydroxyaryl-protein kinase
fibroblast growth factor receptor 3 variant 4
NP_000133.1
NP_001156685.1
NP_075254.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012632.1 

    Range
    5001..20561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000142.4NP_000133.1  fibroblast growth factor receptor 3 isoform 1 precursor

    See proteins identical to NP_000133.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript. The resulting protein (isoform 1) has the IIIc-type C-terminal half of the IgIII domain.
    Source sequence(s)
    AC016773, AW204106, BC121175, DR003490, M64347
    Consensus CDS
    CCDS3353.1
    UniProtKB/Swiss-Prot
    P22607
    UniProtKB/TrEMBL
    Q0IJ44
    Related
    ENSP00000414914, ENST00000440486
    Conserved Domains (7) summary
    cd05857
    Location:161245
    Blast Score: 465
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:268357
    Blast Score: 483
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:170235
    Blast Score: 181
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:260356
    Blast Score: 167
    IG_like; Immunoglobulin like
    pfam07714
    Location:472748
    Blast Score: 1099
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:459792
    Blast Score: 1809
    PKc_like; Protein Kinases, catalytic domain
    cl11960
    Location:54109
    Blast Score: 106
    Ig; Immunoglobulin domain
  2. NM_001163213.1NP_001156685.1  fibroblast growth factor receptor 3 isoform 3 precursor

    See proteins identical to NP_001156685.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as isoform IIIb, contains alternatively spliced exon 8 but lacks exon 9, compared to variant 1. The resulting protein (isoform 3) has the IIIb-type C-terminal half of the IgIII domain and is longer when it is compared to isoform 1.
    Source sequence(s)
    AB209441, AC016773, AW204106, BC121175
    Consensus CDS
    CCDS54706.1
    UniProtKB/Swiss-Prot
    P22607
    UniProtKB/TrEMBL
    Q0IJ44
    Related
    ENSP00000339824, ENST00000340107
    Conserved Domains (7) summary
    cd04974
    Location:268356
    Blast Score: 364
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Blast Score: 465
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:170235
    Blast Score: 181
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:260355
    Blast Score: 154
    IG_like; Immunoglobulin like
    pfam07714
    Location:474750
    Blast Score: 1099
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:461794
    Blast Score: 1809
    PKc_like; Protein Kinases, catalytic domain
    cl11960
    Location:54109
    Blast Score: 106
    Ig; Immunoglobulin domain
  3. NM_022965.3NP_075254.1  fibroblast growth factor receptor 3 isoform 2 precursor

    See proteins identical to NP_075254.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks exons 8, 9 and 10, compared to variant 1. The resulting protein (isoform 2) is missing the C-terminal half of the IgIII domain and the transmembrane region, compared to isoform 1. The missing transmembrane region suggests that isoform 2 is a soluble receptor.
    Source sequence(s)
    AC016773, AF245114, AW204106, BC121175, DR003490
    Consensus CDS
    CCDS3354.1
    UniProtKB/Swiss-Prot
    P22607
    UniProtKB/TrEMBL
    Q0IJ44
    Related
    ENSP00000412903, ENST00000412135
    Conserved Domains (7) summary
    cd04974
    Location:268357
    Blast Score: 364
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Blast Score: 465
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:170235
    Blast Score: 181
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:260289
    Blast Score: 89
    IG; Immunoglobulin
    pfam07714
    Location:360636
    Blast Score: 1099
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:347680
    Blast Score: 1799
    PKc_like; Protein Kinases, catalytic domain
    cl11960
    Location:54109
    Blast Score: 105
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12 

    Range
    1793299..1808872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713868.1XP_006713931.1  

    Conserved Domains (7) summary
    cd04974
    Location:268356
    Blast Score: 364
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Blast Score: 465
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:170235
    Blast Score: 181
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:260355
    Blast Score: 154
    IG_like; Immunoglobulin like
    pfam07714
    Location:476752
    Blast Score: 1099
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:463797
    Blast Score: 1798
    PKc_like; Protein Kinases, catalytic domain
    cl11960
    Location:54109
    Blast Score: 106
    Ig; Immunoglobulin domain
  2. XM_006713869.1XP_006713932.1  

    Conserved Domains (7) summary
    cd04974
    Location:268356
    Blast Score: 364
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Blast Score: 465
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:170235
    Blast Score: 181
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:260355
    Blast Score: 154
    IG_like; Immunoglobulin like
    pfam07714
    Location:476752
    Blast Score: 1099
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:463796
    Blast Score: 1810
    PKc_like; Protein Kinases, catalytic domain
    cl11960
    Location:54109
    Blast Score: 106
    Ig; Immunoglobulin domain
  3. XM_006713870.1XP_006713933.1  

    Conserved Domains (7) summary
    cd04974
    Location:268356
    Blast Score: 364
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Blast Score: 465
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:170235
    Blast Score: 181
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:260355
    Blast Score: 154
    IG_like; Immunoglobulin like
    pfam07714
    Location:475751
    Blast Score: 1099
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:462796
    Blast Score: 1798
    PKc_like; Protein Kinases, catalytic domain
    cl11960
    Location:54109
    Blast Score: 106
    Ig; Immunoglobulin domain
  4. XM_006713871.1XP_006713934.1  

    Conserved Domains (7) summary
    cd04974
    Location:268356
    Blast Score: 364
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Blast Score: 465
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:170235
    Blast Score: 181
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:260355
    Blast Score: 154
    IG_like; Immunoglobulin like
    pfam07714
    Location:474750
    Blast Score: 1099
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:461795
    Blast Score: 1798
    PKc_like; Protein Kinases, catalytic domain
    cl11960
    Location:54109
    Blast Score: 106
    Ig; Immunoglobulin domain
  5. XM_006713872.1XP_006713935.1  

    See proteins identical to XP_006713935.1

    UniProtKB/TrEMBL
    X5D2G8
    Related
    ENSP00000420533, OTTHUMP00000217007, ENST00000481110, OTTHUMT00000358204
    Conserved Domains (7) summary
    cd05857
    Location:161245
    Blast Score: 465
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:268357
    Blast Score: 483
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:170235
    Blast Score: 181
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:260356
    Blast Score: 167
    IG_like; Immunoglobulin like
    pfam07714
    Location:473749
    Blast Score: 1099
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:460793
    Blast Score: 1809
    PKc_like; Protein Kinases, catalytic domain
    cl11960
    Location:54109
    Blast Score: 106
    Ig; Immunoglobulin domain
  6. XM_006713873.1XP_006713936.1  

    Conserved Domains (7) summary
    cd05857
    Location:161245
    Blast Score: 465
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:268357
    Blast Score: 483
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:170235
    Blast Score: 181
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:260356
    Blast Score: 167
    IG_like; Immunoglobulin like
    pfam07714
    Location:472748
    Blast Score: 1099
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:459793
    Blast Score: 1797
    PKc_like; Protein Kinases, catalytic domain
    cl11960
    Location:54109
    Blast Score: 106
    Ig; Immunoglobulin domain

Alternate HuRef

Genomic

  1. AC_000136.1 

    Range
    1725137..1753471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 

    Range
    1792977..1808551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)