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CEL carboxyl ester lipase [ Homo sapiens (human) ]

Gene ID: 1056, updated on 13-Sep-2014
Official Symbol
CELprovided by HGNC
Official Full Name
carboxyl ester lipaseprovided by HGNC
Primary source
HGNC:HGNC:1848
See related
Ensembl:ENSG00000170835; HPRD:07509; MIM:114840; Vega:OTTHUMG00000020855
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAL; FAP; BSDL; BSSL; CELL; FAPP; LIPA; CEase; MODY8
Summary
The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]
Location:
9q34.3
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 9 NC_000009.12 (133061978..133071863)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (135936741..135947250)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene general transcription factor IIIC, polypeptide 5, 63kDa Neighboring gene microRNA 6877 Neighboring gene uncharacterized LOC100996574 Neighboring gene regulating synaptic membrane exocytosis protein 1-like Neighboring gene carboxyl ester lipase pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Bile salt-stimulated lipase (BSSL) isolated from human milk binds to DC-SIGN, preventing HIV-1 gp120 from interacting with this receptor PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acylglycerol lipase activity TAS
Traceable Author Statement
more info
 
catalytic activity TAS
Traceable Author Statement
more info
PubMed 
heparin binding NAS
Non-traceable Author Statement
more info
PubMed 
hydrolase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sterol esterase activity NAS
Non-traceable Author Statement
more info
PubMed 
sterol esterase activity TAS
Traceable Author Statement
more info
 
triglyceride lipase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cholesterol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
fatty acid catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
intestinal cholesterol absorption NAS
Non-traceable Author Statement
more info
PubMed 
intestinal lipid catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
lipid digestion TAS
Traceable Author Statement
more info
 
lipid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
pancreatic juice secretion IDA
Inferred from Direct Assay
more info
PubMed 
protein esterification NAS
Non-traceable Author Statement
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
triglyceride metabolic process IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
Preferred Names
bile salt-activated lipase
Names
bile salt-activated lipase
bucelipase
sterol esterase
cholesterol esterase
carboxyl ester hydrolase
fetoacinar pancreatic protein
lysophospholipase, pancreatic
bile salt-dependent lipase, oncofetal isoform
carboxyl ester lipase (bile salt-stimulated lipase)
NP_001798.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016394.1 

    Range
    5001..14886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001807.4NP_001798.2  bile salt-activated lipase precursor

    Status: REVIEWED

    Source sequence(s)
    AF081673, AK299965, AL162417, BC042510, BE045879
    Consensus CDS
    CCDS43896.1
    UniProtKB/TrEMBL
    B4DSX9
    UniProtKB/TrEMBL
    O75612
    UniProtKB/TrEMBL
    Q86SR3
    UniProtKB/TrEMBL
    X6R868
    Related
    ENSP00000361151, OTTHUMP00000022450, ENST00000372080, OTTHUMT00000054823
    Conserved Domains (5) summary
    pfam06346
    Location:571718
    Drf_FH1; Formin Homology Region 1
    COG0657
    Location:119251
    Aes; Esterase/lipase [Lipid metabolism]
    cd00312
    Location:28535
    Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...
    cl09133
    Location:624682
    COG1615; Uncharacterized conserved protein [Function unknown]
    pfam10428
    Location:602744
    SOG2; RAM signalling pathway protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000009.12 

    Range
    133061978..133071863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000141.1 

    Range
    105431068..105440909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 

    Range
    136087941..136097924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)