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LAMB1 laminin, beta 1 [ Homo sapiens (human) ]

Gene ID: 3912, updated on 7-Dec-2014
Official Symbol
LAMB1provided by HGNC
Official Full Name
laminin, beta 1provided by HGNC
Primary source
HGNC:HGNC:6486
See related
Ensembl:ENSG00000091136; HPRD:01029; MIM:150240; Vega:OTTHUMG00000149966
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLM; LIS5
Summary
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011]
See LAMB1 in Epigenomics, MapViewer
Location:
7q22
Exon count:
34
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 7 NC_000007.14 (107923801..108003359, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (107564244..107643804, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class C pseudogene 2 Neighboring gene dihydrolipoamide dehydrogenase Neighboring gene laminin, beta 4 Neighboring gene uncharacterized LOC102724363 Neighboring gene neuronal cell adhesion molecule

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Lissencephaly 5
MedGen: CN169267 OMIM: 615191 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
NHGRI GWA Catalog
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution PubMed
tat HIV-1 Tat enhances adhesion of human U937 monocyte-like cells to proteins of the extracellular matrix, such as collagen IV, laminin, and ECM1 PubMed
tat HIV-1 Tat upregulates the expression of extracellular matrix proteins, including the major basement membrane protein laminin PubMed

Go to the HIV-1, Human Interaction Database

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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC142015

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix structural constituent IDA
Inferred from Direct Assay
more info
PubMed 
glycosphingolipid binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding IEA
Inferred from Electronic Annotation
more info
 
structural molecule activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
axon guidance TAS
Traceable Author Statement
more info
 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
embryo implantation IEA
Inferred from Electronic Annotation
more info
 
endodermal cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
extracellular matrix disassembly TAS
Traceable Author Statement
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
negative regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
neuronal-glial interaction involved in cerebral cortex radial glia guided migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
odontogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell proliferation TAS
Traceable Author Statement
more info
PubMed 
substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
basement membrane TAS
Traceable Author Statement
more info
PubMed 
extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
laminin-1 complex IDA
Inferred from Direct Assay
more info
PubMed 
laminin-1 complex IPI
Inferred from Physical Interaction
more info
PubMed 
laminin-1 complex TAS
Traceable Author Statement
more info
PubMed 
laminin-10 complex IDA
Inferred from Direct Assay
more info
PubMed 
laminin-2 complex IDA
Inferred from Direct Assay
more info
PubMed 
laminin-2 complex TAS
Traceable Author Statement
more info
PubMed 
laminin-8 complex IDA
Inferred from Direct Assay
more info
PubMed 
laminin-8 complex TAS
Traceable Author Statement
more info
PubMed 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
laminin subunit beta-1
Names
laminin subunit beta-1
laminin B1 chain

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023255.1 

    Range
    5001..84559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002291.2NP_002282.2  laminin subunit beta-1 precursor

    See proteins identical to NP_002282.2

    Status: REVIEWED

    Source sequence(s)
    AC078853, BC026018, BC113455, DA861108
    Consensus CDS
    CCDS5750.1
    UniProtKB/Swiss-Prot
    P07942
    UniProtKB/TrEMBL
    Q8TAS6
    Related
    ENSP00000222399, OTTHUMP00000195574, ENST00000222399, OTTHUMT00000314584
    Conserved Domains (5) summary
    COG1340
    Location:14521778
    COG1340; Uncharacterized archaeal coiled-coil protein [Function unknown]
    cd00055
    Location:772819
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:35269
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam01044
    Location:14461781
    Vinculin; Vinculin family
    cl12013
    Location:12161327
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14 

    Range
    107923801..108003359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 

    Range
    107497967..107577516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000139.1 

    Range
    101926690..102006298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)