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NRXN1 neurexin 1 [ Homo sapiens (human) ]

Gene ID: 9378, updated on 6-Jul-2014
Official Symbol
NRXN1provided by HGNC
Official Full Name
neurexin 1provided by HGNC
Primary source
HGNC:8008
See related
Ensembl:ENSG00000179915; HPRD:11858; MIM:600565; Vega:OTTHUMG00000129263
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTHSL2; SCZD17; Hs.22998
Summary
Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq Project has decided to create only a few representative transcript variants of the multitude that are possible. [provided by RefSeq, Oct 2008]
Annotation information
Note: The neurexin genes use alternate promoters, splice sites and exons to encode potentially hundreds or thousands of mRNA transcripts. The RefSeq Project has chosen to represent the longest protein isoform and one transcript variant each for the alpha and beta isoforms. [13 Feb 2013]
See NRXN1 in Epigenomics, MapViewer
Location:
2p16.3
Exon count :
28
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (49918505..51032536, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (50145643..51259674, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene microRNA 548ba Neighboring gene follicle stimulating hormone receptor Neighboring gene ribosomal protein L7 pseudogene 13 Neighboring gene uncharacterized LOC101927089 Neighboring gene uncharacterized LOC730100 Neighboring gene lysine-rich nucleolar protein 1 pseudogene 3 Neighboring gene crystallin, gamma G, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Pitt-Hopkins-like syndrome 2
MedGen: C3280479 OMIM: 614325 GeneReviews: Not available
Compare labs
Schizophrenia 17
MedGen: C3280524 OMIM: 614332 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2012-05-17)

ISCA Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2012-05-17)

ISCA Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
A genome-wide association study of behavioral disinhibition.
NHGRI GWA Catalog
A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality.
NHGRI GWA Catalog
A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
NHGRI GWA Catalog
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
NHGRI GWA Catalog
Joint influence of small-effect genetic variants on human longevity.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of neurexin 1 (NRXN1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
  • Non-integrin membrane-ECM interactions, organism-specific biosystem (from REACTOME)
    Non-integrin membrane-ECM interactions, organism-specific biosystemSeveral non-integrin membrane proteins interact with extracellular matrix proteins. Transmembrane proteoglycans may associate with integrins and growth factor receptors to influence their function, o...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acetylcholine receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion molecule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
neuroligin family protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity TAS
Traceable Author Statement
more info
PubMed 
receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
N-methyl-D-aspartate receptor clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
adult behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
axon guidance TAS
Traceable Author Statement
more info
PubMed 
calcium-dependent cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
cerebellar granule cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
establishment of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
gamma-aminobutyric acid receptor clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
gephyrin clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
guanylate kinase-associated protein clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
heterophilic cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
neuroligin clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuromuscular process controlling balance ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
neuron cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron cell-cell adhesion TAS
Traceable Author Statement
more info
PubMed 
neuronal signal transduction TAS
Traceable Author Statement
more info
PubMed 
neurotransmitter secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of establishment of protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of excitatory postsynaptic membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synapse maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic density protein 95 clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
prepulse inhibition IEA
Inferred from Electronic Annotation
more info
 
presynaptic membrane assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor localization to synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of N-methyl-D-aspartate selective glutamate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of grooming behavior IEA
Inferred from Electronic Annotation
more info
 
social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
vocal learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
vocalization behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axonal growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
endocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IC
Inferred by Curator
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
presynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
presynaptic membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
neurexin-1-beta
Names
neurexin-1-beta
neurexin I

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011878.1 

    Range
    5001..1119032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135659.1NP_001129131.1  neurexin-1-beta isoform alpha2 precursor

    See proteins identical to NP_001129131.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha2) represents the transcript that encodes the longest protein (isoform alpha2) of the three representative RefSeq records.
    Source sequence(s)
    BC150247, BM021375, DA168874, DA320230, EF539882
    Consensus CDS
    CCDS46282.1
    UniProtKB/TrEMBL
    A7E294
    UniProtKB/Swiss-Prot
    Q9ULB1
    Conserved Domains (4) summary
    smart00294
    Location:14921510
    Blast Score: 100
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:720753
    Blast Score: 114
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:521690
    Blast Score: 353
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14721527
    Blast Score: 93
    Syndecan; Syndecan domain
  2. NM_004801.4NP_004792.1  neurexin-1-beta isoform alpha1 precursor

    See proteins identical to NP_004792.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha1) lacks several segments in the coding region, as compared to variant alpha2. The resulting protein (isoform alpha1) is shorter when it is compared to isoform alpha2.
    Source sequence(s)
    AB035356, AK124726, BC046631, BC125179, BC150247, BM021375, DA168874, EF539882
    Consensus CDS
    CCDS54360.1
    UniProtKB/TrEMBL
    A4FVB9
    UniProtKB/TrEMBL
    A7E294
    UniProtKB/TrEMBL
    Q49A31
    UniProtKB/Swiss-Prot
    Q9ULB1
    Related
    ENSP00000384311, OTTHUMP00000201211, ENST00000406316, OTTHUMT00000325291
    Conserved Domains (4) summary
    smart00294
    Location:14221440
    Blast Score: 100
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:680713
    Blast Score: 115
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:481650
    Blast Score: 352
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14021457
    Blast Score: 93
    Syndecan; Syndecan domain
  3. NM_138735.2NP_620072.1  neurexin-1-beta isoform beta precursor

    See proteins identical to NP_620072.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta) represents a beta neurexin transcript. It is transcribed from a downstream promoter, includes a different segment for its 5' UTR and 5' coding region, and lacks most of the 5' exons present in alpha transcripts, as compared to variant alpha2. The resulting protein (isoform beta) has a shorter and distinct N-terminus when it is compared to isoform alpha2.
    Source sequence(s)
    AC068725, BC125179, BC150247, BM021375, DA168874, EF539882
    Consensus CDS
    CCDS1845.1
    UniProtKB/TrEMBL
    A4FVB9
    UniProtKB/TrEMBL
    A7E294
    UniProtKB/Swiss-Prot
    P58400
    UniProtKB/Swiss-Prot
    Q9ULB1
    Related
    ENSP00000341184, OTTHUMP00000159578, ENST00000342183, OTTHUMT00000251372
    Conserved Domains (3) summary
    smart00294
    Location:387405
    Blast Score: 99
    4.1m; putative band 4.1 homologues' binding motif
    cd00110
    Location:90238
    Blast Score: 238
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:367422
    Blast Score: 93
    Syndecan; Syndecan domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 

    Range
    49918505..51032536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712135.1XP_006712198.1  

    Conserved Domains (4) summary
    smart00294
    Location:14361454
    Blast Score: 100
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:667700
    Blast Score: 115
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:468637
    Blast Score: 353
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14161471
    Blast Score: 93
    Syndecan; Syndecan domain
  2. XM_006712136.1XP_006712199.1  

    Conserved Domains (4) summary
    smart00294
    Location:14321450
    Blast Score: 100
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:672705
    Blast Score: 116
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:473642
    Blast Score: 352
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14121467
    Blast Score: 93
    Syndecan; Syndecan domain
  3. XM_006712139.1XP_006712202.1  

    Conserved Domains (4) summary
    smart00294
    Location:14111429
    Blast Score: 100
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:672705
    Blast Score: 115
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:473642
    Blast Score: 353
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:13911446
    Blast Score: 93
    Syndecan; Syndecan domain
  4. XM_005264643.1XP_005264700.1  

    See proteins identical to XP_005264700.1

    UniProtKB/TrEMBL
    A7E294
    Conserved Domains (4) summary
    smart00294
    Location:14411459
    Blast Score: 100
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:672705
    Blast Score: 115
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:473642
    Blast Score: 353
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14211476
    Blast Score: 93
    Syndecan; Syndecan domain
  5. XM_006712138.1XP_006712201.1  

    Conserved Domains (4) summary
    smart00294
    Location:14191437
    Blast Score: 100
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:680713
    Blast Score: 115
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:481650
    Blast Score: 353
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:13991454
    Blast Score: 93
    Syndecan; Syndecan domain
  6. XM_006712133.1XP_006712196.1  

    Conserved Domains (4) summary
    smart00294
    Location:14491467
    Blast Score: 100
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:680713
    Blast Score: 115
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:481650
    Blast Score: 353
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14291484
    Blast Score: 93
    Syndecan; Syndecan domain
  7. XM_006712134.1XP_006712197.1  

    Conserved Domains (4) summary
    smart00294
    Location:14471465
    Blast Score: 100
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:687720
    Blast Score: 116
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:488657
    Blast Score: 352
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14271482
    Blast Score: 93
    Syndecan; Syndecan domain
  8. XM_006712137.1XP_006712200.1  

    Conserved Domains (4) summary
    smart00294
    Location:14261444
    Blast Score: 100
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:687720
    Blast Score: 114
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:488657
    Blast Score: 353
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14061461
    Blast Score: 93
    Syndecan; Syndecan domain
  9. XM_005264642.1XP_005264699.1  

    Conserved Domains (4) summary
    smart00294
    Location:14561474
    Blast Score: 100
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:687720
    Blast Score: 115
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:488657
    Blast Score: 353
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14361491
    Blast Score: 93
    Syndecan; Syndecan domain
  10. XM_006712143.1XP_006712206.1  

    Conserved Domains (4) summary
    smart00294
    Location:11671185
    Blast Score: 100
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:407440
    Blast Score: 118
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:208377
    Blast Score: 352
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:11471202
    Blast Score: 93
    Syndecan; Syndecan domain
  11. XM_006712142.1XP_006712205.1  

    Conserved Domains (4) summary
    smart00294
    Location:11761194
    Blast Score: 100
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:407440
    Blast Score: 117
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:208377
    Blast Score: 352
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:11561211
    Blast Score: 93
    Syndecan; Syndecan domain
  12. XM_006712144.1XP_006712207.1  

    Conserved Domains (3) summary
    smart00294
    Location:384402
    Blast Score: 99
    4.1m; putative band 4.1 homologues' binding motif
    cd00110
    Location:90238
    Blast Score: 239
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:364419
    Blast Score: 93
    Syndecan; Syndecan domain
  13. XM_006712140.1XP_006712203.1  

    Conserved Domains (2) summary
    cd00054
    Location:687720
    Blast Score: 114
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:488657
    Blast Score: 351
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  14. XM_006712141.1XP_006712204.1  

    Conserved Domains (2) summary
    cd00054
    Location:687720
    Blast Score: 113
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:488657
    Blast Score: 349
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

Alternate HuRef

Genomic

  1. AC_000134.1 

    Range
    49879094..50994141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 

    Range
    50076199..51190490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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