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WNT1 wingless-type MMTV integration site family, member 1 [ Homo sapiens (human) ]

Gene ID: 7471, updated on 5-Apr-2015
Official Symbol
WNT1provided by HGNC
Official Full Name
wingless-type MMTV integration site family, member 1provided by HGNC
Primary source
HGNC:HGNC:12774
See related
HPRD:01276; MIM:164820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INT1; OI15; BMND16
Summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
Orthologs
See WNT1 in MapViewer
Location:
12q13
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (48978453..48982613)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49372236..49376396)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor 3 Neighboring gene wingless-type MMTV integration site family, member 10B Neighboring gene uncharacterized LOC105369757 Neighboring gene uncharacterized LOC105369756 Neighboring gene uncharacterized LOC105369758 Neighboring gene dendrin

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of wingless-type MMTV integration site family, member 1 (WNT1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-mediated downregulation of beta-catenin/Wnt signaling is dependent on the core and cysteine-rich domains (residues 20-48) of Tat PubMed

Go to the HIV-1, Human Interaction Database

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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity ISS
Inferred from Sequence or Structural Similarity
more info
 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
 
frizzled binding IC
Inferred by Curator
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
receptor agonist activity IC
Inferred by Curator
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Spemann organizer formation ISS
Inferred from Sequence or Structural Similarity
more info
 
T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway involved in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
cell-cell signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to peptide hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
central nervous system morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cerebellum formation ISS
Inferred from Sequence or Structural Similarity
more info
 
diencephalon development IEA
Inferred from Electronic Annotation
more info
 
embryonic axis specification ISS
Inferred from Sequence or Structural Similarity
more info
 
forebrain anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
hematopoietic stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
hepatocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
inner ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
midbrain development ISS
Inferred from Sequence or Structural Similarity
more info
 
midbrain-hindbrain boundary maturation during brain development IEA
Inferred from Electronic Annotation
more info
 
myoblast fusion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell aging IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
neuron fate determination IEA
Inferred from Electronic Annotation
more info
 
organ regeneration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of dermatome development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
signal transduction in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
spinal cord association neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent SMAD protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
proto-oncogene Wnt-1
Names
proto-oncogene Wnt-1
proto-oncogene Int-1 homolog
wingless-type MMTV integration site family, member 1 (oncogene INT1)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033141.1 RefSeqGene

    Range
    5001..9161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005430.3NP_005421.1  proto-oncogene Wnt-1 precursor

    See proteins identical to NP_005421.1

    Status: REVIEWED

    Source sequence(s)
    AC073610, BC074798
    Consensus CDS
    CCDS8776.1
    UniProtKB/Swiss-Prot
    P04628
    Conserved Domains (1) summary
    smart00097
    Location:60370
    WNT1; found in Wnt-1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    48978453..48982613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    49338028..49342188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)