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MSR1 macrophage scavenger receptor 1 [ Homo sapiens (human) ]

Gene ID: 4481, updated on 17-Mar-2015
Official Symbol
MSR1provided by HGNC
Official Full Name
macrophage scavenger receptor 1provided by HGNC
Primary source
HGNC:HGNC:7376
See related
Ensembl:ENSG00000038945; HPRD:01092; MIM:153622; Vega:OTTHUMG00000094809
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRA; SR-A; CD204; phSR1; phSR2; SCARA1
Summary
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
Orthologs
See MSR1 in MapViewer
Location:
8p22
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (16107878..16192791, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (15965387..16050300, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1A, pseudogene 1 Neighboring gene ribosomal protein L32 pseudogene 19 Neighboring gene chaperonin containing TCP1, subunit 3 (gamma) pseudogene 1 Neighboring gene uncharacterized LOC101929028 Neighboring gene mitochondrial ribosomal protein L49 pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • AGE/RAGE pathway, organism-specific biosystem (from WikiPathways)
    AGE/RAGE pathway, organism-specific biosystemAdvanced glycation end products (AGEs) are heterogeneous group of non-enzymatic malliard reaction products of aldose sugar with proteins and lipids. Formation of AGEs is an indicator of one of the ma...
  • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
    Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemScavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). So...
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Scavenging by Class A Receptors, organism-specific biosystem (from REACTOME)
    Scavenging by Class A Receptors, organism-specific biosystemClass A scavenger receptors contain an intracellular domain, a transmembrane region, a coiled-coil domain, a collagenous domain, and the SR cysteine-rich domain (reviewed in Areschoug and Gordon 2009...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
low-density lipoprotein particle binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
cholesterol transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
lipoprotein transport IEA
Inferred from Electronic Annotation
more info
 
plasma lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cholesterol storage ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of macrophage derived foam cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
collagen trimer IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
macrophage scavenger receptor types I and II
Names
macrophage scavenger receptor types I and II
macrophage acetylated LDL receptor I and II
macrophage scavenger receptor type III
scavenger receptor class A member 1
scavenger receptor class A, member 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012102.1 RefSeqGene

    Range
    5001..89914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002445.3NP_002436.1  macrophage scavenger receptor types I and II isoform type 2

    See proteins identical to NP_002436.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (SR-AII), also known as phSR2, uses two alternative exons and also lacks two downstream exons compared to variant SR-AI. These differences causes an alternate 3' end in the coding region, and has a distinct 3' UTR. It encodes isoform type 2 that is shorter and has a different C-terminus than isoform type 1.
    Source sequence(s)
    AC023396, D90188, DA995755
    Consensus CDS
    CCDS5997.1
    UniProtKB/Swiss-Prot
    P21757
    Related
    ENSP00000371428, OTTHUMP00000120050, ENST00000381998, OTTHUMT00000211635
    Conserved Domains (3) summary
    pfam01391
    Location:280334
    Collagen; Collagen triple helix repeat (20 copies)
    pfam03523
    Location:121169
    Macscav_rec; Macrophage scavenger receptor
    pfam05615
    Location:149249
    THOC7; Tho complex subunit 7
  2. NM_138715.2NP_619729.1  macrophage scavenger receptor types I and II isoform type 1

    See proteins identical to NP_619729.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (SR-AI), also known as phSR1, encodes the longest isoform.
    Source sequence(s)
    AC023396, D90187, DA995755
    Consensus CDS
    CCDS5995.1
    UniProtKB/Swiss-Prot
    P21757
    Conserved Domains (4) summary
    pfam01391
    Location:280334
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:350450
    SR; Scavenger receptor Cys-rich
    pfam03523
    Location:121169
    Macscav_rec; Macrophage scavenger receptor
    pfam05615
    Location:149249
    THOC7; Tho complex subunit 7
  3. NM_138716.2NP_619730.1  macrophage scavenger receptor types I and II isoform type 3

    See proteins identical to NP_619730.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (SR-AIII) lacks an exon in the coding region, but maintains the same reading frame, as compared to variant SR-AI. It encodes an isoform type 3 that lacks 63 internal amino acids compared to isoform type 1.
    Source sequence(s)
    AC023396, D90187, DA995755
    Consensus CDS
    CCDS5996.1
    UniProtKB/Swiss-Prot
    P21757
    Related
    ENSP00000262100, ENST00000350896
    Conserved Domains (4) summary
    pfam01391
    Location:280334
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00530
    Location:331387
    SRCR; Scavenger receptor cysteine-rich domain
    pfam03523
    Location:121169
    Macscav_rec; Macrophage scavenger receptor
    pfam05615
    Location:149249
    THOC7; Tho complex subunit 7

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    16107878..16192791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    16167312..16251899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)