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MTFMT mitochondrial methionyl-tRNA formyltransferase [ Homo sapiens (human) ]

Gene ID: 123263, updated on 11-Sep-2014
Official Symbol
MTFMTprovided by HGNC
Official Full Name
mitochondrial methionyl-tRNA formyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:29666
See related
Ensembl:ENSG00000103707; HPRD:14799; MIM:611766
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FMT1; COXPD15
Summary
The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA. [provided by RefSeq, Jun 2011]
See MTFMT in Epigenomics, MapViewer
Location:
15q22.31
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 15 NC_000015.10 (65001512..65029639, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65293850..65321977, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and death domain containing 1A Neighboring gene spastic paraplegia 21 (autosomal recessive, Mast syndrome) Neighboring gene transmembrane protein 126A pseudogene Neighboring gene solute carrier family 51, beta subunit Neighboring gene RAS-like, family 12 Neighboring gene kelch repeat and BTB (POZ) domain containing 13

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
methionyl-tRNA formyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IEA
Inferred from Electronic Annotation
more info
 
translational initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
methionyl-tRNA formyltransferase, mitochondrial
Names
methionyl-tRNA formyltransferase, mitochondrial
NP_640335.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029184.1 

    Range
    5001..33128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139242.3NP_640335.2  methionyl-tRNA formyltransferase, mitochondrial

    See proteins identical to NP_640335.2

    Status: REVIEWED

    Source sequence(s)
    AC103691, BC033687, BQ774051, DC295382
    Consensus CDS
    CCDS45280.1
    UniProtKB/Swiss-Prot
    Q96DP5
    Related
    ENSP00000220058, OTTHUMP00000248255, ENST00000220058, OTTHUMT00000418155
    Conserved Domains (3) summary
    cd08646
    Location:48244
    Blast Score: 585
    FMT_core_Met-tRNA-FMT_N; Methionyl-tRNA formyltransferase, N-terminal hydrolase domain
    TIGR00460
    Location:49360
    Blast Score: 939
    fmt; methionyl-tRNA formyltransferase
    pfam02911
    Location:243350
    Blast Score: 149
    Formyl_trans_C; Formyl transferase, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000015.10 

    Range
    65001512..65029639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254158.2XP_005254215.1  

    See proteins identical to XP_005254215.1

    UniProtKB/Swiss-Prot
    Q96DP5
    Conserved Domains (2) summary
    cd08646
    Location:10159
    Blast Score: 488
    FMT_core_Met-tRNA-FMT_N; Methionyl-tRNA formyltransferase, N-terminal hydrolase domain
    pfam02911
    Location:158265
    Blast Score: 151
    Formyl_trans_C; Formyl transferase, C-terminal domain

Alternate HuRef

Genomic

  1. AC_000147.1 

    Range
    42118760..42146953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 

    Range
    65413707..65441816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)