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STAMBP STAM binding protein [ Homo sapiens (human) ]

Gene ID: 10617, updated on 12-Apr-2015
Official Symbol
STAMBPprovided by HGNC
Official Full Name
STAM binding proteinprovided by HGNC
Primary source
HGNC:HGNC:16950
See related
Ensembl:ENSG00000124356; HPRD:05877; MIM:606247; Vega:OTTHUMG00000129817
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMSH; MICCAP
Summary
Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
See STAMBP in MapViewer
Location:
2p13.1
Exon count:
16
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (73828916..73873656)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74056043..74100783)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) Neighboring gene chromosome 2 open reading frame 78 Neighboring gene uncharacterized LOC105374807 Neighboring gene uncharacterized LOC105374806 Neighboring gene zinc finger, DHHC-type containing 6 pseudogene Neighboring gene actin, gamma 2, smooth muscle, enteric

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Internalization of ErbB1, organism-specific biosystem (from Pathway Interaction Database)
    Internalization of ErbB1, organism-specific biosystem
    Internalization of ErbB1
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC126516, MGC126518

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
JAK-STAT cascade TAS
Traceable Author Statement
more info
PubMed 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
STAM-binding protein
Names
STAM-binding protein
associated molecule with the SH3 domain of STAM
endosome-associated ubiquitin isopeptidase
NP_006454.1
NP_964010.1
NP_998787.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033223.1 RefSeqGene

    Range
    5001..43253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006463.4NP_006454.1  STAM-binding protein

    See identical proteins and their annotated locations for NP_006454.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC073046, BC101467, DB477012, DR158757
    Consensus CDS
    CCDS1929.1
    UniProtKB/Swiss-Prot
    O95630
    Related
    ENSP00000377636, ENST00000394073
    Conserved Domains (2) summary
    cd08066
    Location:254424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:13117
    USP8_dimer; USP8 dimerization domain
  2. NM_201647.2NP_964010.1  STAM-binding protein

    See identical proteins and their annotated locations for NP_964010.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC073046, DN919763, U73522
    Consensus CDS
    CCDS1929.1
    UniProtKB/Swiss-Prot
    O95630
    Related
    ENSP00000344742, ENST00000339566
    Conserved Domains (2) summary
    cd08066
    Location:254424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:13117
    USP8_dimer; USP8 dimerization domain
  3. NM_213622.2NP_998787.1  STAM-binding protein

    See identical proteins and their annotated locations for NP_998787.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC073046, BC065574, CX758449
    Consensus CDS
    CCDS1929.1
    UniProtKB/Swiss-Prot
    O95630
    Related
    ENSP00000377633, OTTHUMP00000160249, ENST00000394070, OTTHUMT00000252048
    Conserved Domains (2) summary
    cd08066
    Location:254424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:13117
    USP8_dimer; USP8 dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    73828916..73873656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264088.2XP_005264145.1  

    See identical proteins and their annotated locations for XP_005264145.1

    UniProtKB/Swiss-Prot
    O95630
    Conserved Domains (2) summary
    cd08066
    Location:254424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:13117
    USP8_dimer; USP8 dimerization domain
  2. XM_011532483.1XP_011530785.1  

    See identical proteins and their annotated locations for XP_011530785.1

    Related
    ENSP00000386548, OTTHUMP00000202512, ENST00000409707, OTTHUMT00000328094
    Conserved Domains (2) summary
    cd08066
    Location:254424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:13117
    USP8_dimer; USP8 dimerization domain
  3. XM_011532484.1XP_011530786.1  

    Conserved Domains (2) summary
    cd08066
    Location:254405
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:13117
    USP8_dimer; USP8 dimerization domain
  4. XM_011532485.1XP_011530787.1  

    Conserved Domains (2) summary
    pfam08969
    Location:13117
    USP8_dimer; USP8 dimerization domain
    cl13996
    Location:254335
    MPN; Mpr1p, Pad1p N-terminal (MPN) domains
  5. XM_005264091.2XP_005264148.1  

    Conserved Domains (1) summary
    cd08066
    Location:119289
    MPN_AMSH_like; Mov34/MPN/PAD-1 family

RNA

  1. XR_939651.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    73985403..74023636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)