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GPR183 G protein-coupled receptor 183 [ Homo sapiens (human) ]

Gene ID: 1880, updated on 26-Aug-2014
Official Symbol
GPR183provided by HGNC
Official Full Name
G protein-coupled receptor 183provided by HGNC
Primary source
HGNC:3128
Locus tag
RP11-461N23.2
See related
Ensembl:ENSG00000169508; HPRD:12040; MIM:605741; Vega:OTTHUMG00000017263
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EBI2
Summary
This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008]
See GPR183 in Epigenomics, MapViewer
Location:
13q32.3
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 13 NC_000013.11 (99294535..99307495, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (99946789..99959749, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene UBA domain containing 2 Neighboring gene H2A histone family, member Z pseudogene 3 Neighboring gene G protein-coupled receptor 18 Neighboring gene FKSG29 Neighboring gene microRNA 623

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of G protein-coupled receptor 183 (GPR183) in Vif-expression T cells PubMed

Go to the HIV-1, Human Protein Interaction Database

  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
oxysterol binding IDA
Inferred from Direct Assay
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 
humoral immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
mature B cell differentiation involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of B cell proliferation IDA
Inferred from Direct Assay
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
G-protein coupled receptor 183
Names
G-protein coupled receptor 183
EBV-induced G-protein coupled receptor 2
epstein-Barr virus-induced G-protein coupled receptor 2
Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004951.4NP_004942.1  G-protein coupled receptor 183

    See proteins identical to NP_004942.1

    Status: REVIEWED

    Source sequence(s)
    AK313443, AW574697, BC020752
    Consensus CDS
    CCDS9492.1
    UniProtKB/Swiss-Prot
    P32249
    Related
    ENSP00000365596, OTTHUMP00000018611, ENST00000376414, OTTHUMT00000045582
    Conserved Domains (3) summary
    pfam00001
    Location:54308
    Blast Score: 538
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10328
    Location:43161
    Blast Score: 106
    7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx
    pfam13853
    Location:195267
    Blast Score: 83
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000013.11 

    Range
    99294535..99307495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000145.1 

    Range
    80541169..80554130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018924.2 

    Range
    99916965..99929926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)