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    ZNF638 zinc finger protein 638 [ Homo sapiens (human) ]

    Gene ID: 27332, updated on 8-Aug-2016
    Official Symbol
    ZNF638provided by HGNC
    Official Full Name
    zinc finger protein 638provided by HGNC
    Primary source
    HGNC:HGNC:17894
    See related
    Ensembl:ENSG00000075292 HPRD:11736; MIM:614349; Vega:OTTHUMG00000129735
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZFML; NP220; Zfp638
    Summary
    The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    2p13.1
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (71276543..71435061)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (71503729..71662191)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein interacting protein 2B Neighboring gene uncharacterized LOC105374797 Neighboring gene RNA, U6 small nuclear 105, pseudogene Neighboring gene dysferlin Neighboring gene uncharacterized LOC107985896

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study in Han Chinese identifies three novel loci for human height.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC26130, MGC90196, DKFZp686P1231

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    double-stranded DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    zinc finger protein 638
    Names
    CTCL tumor antigen se33-1
    CTCL-associated antigen se33-1
    NP220 nuclear protein
    cutaneous T-cell lymphoma-associated antigen se33-1
    nuclear protein 220
    zinc finger matrin-like protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014972.2NP_001014972.1  zinc finger protein 638 isoform 1

      See identical proteins and their annotated locations for NP_001014972.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AI357871, BC143728, BM152722, BP348645, DB130984
      Consensus CDS
      CCDS1917.1
      UniProtKB/Swiss-Prot
      Q14966
      Conserved Domains (4) summary
      smart00451
      Location:19271959
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:10091082
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:676751
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      pfam07382
      Location:741847
      HC2; Histone H1-like nucleoprotein HC2
    2. NM_001252612.1NP_001239541.1  zinc finger protein 638 isoform 1

      See identical proteins and their annotated locations for NP_001239541.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AI357871, BC024000, BC143728, BM152722, BP348645, CR749322, DB094964
      Consensus CDS
      CCDS1917.1
      UniProtKB/Swiss-Prot
      Q14966
      Related
      ENSP00000386433, OTTHUMP00000202229, ENST00000409544, OTTHUMT00000327431
      Conserved Domains (4) summary
      smart00451
      Location:19271959
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:10091082
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:676751
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      pfam07382
      Location:741847
      HC2; Histone H1-like nucleoprotein HC2
    3. NM_001252613.1NP_001239542.1  zinc finger protein 638 isoform 2

      See identical proteins and their annotated locations for NP_001239542.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AI357871, AK291198, BC010355, BC083513, BM152722, BP348645, DB130984
      UniProtKB/Swiss-Prot
      Q14966
      UniProtKB/TrEMBL
      A8K583
      Conserved Domains (4) summary
      cd12436
      Location:10091082
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:676751
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      pfam07382
      Location:741859
      HC2; Histone H1-like nucleoprotein HC2
      pfam14259
      Location:678745
      RRM_6; RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)
    4. NM_014497.4NP_055312.2  zinc finger protein 638 isoform 1

      See identical proteins and their annotated locations for NP_055312.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2 and 3 encode the same isoform.
      Source sequence(s)
      AI357871, BC143728, BM152722, BP348645, D83032, DB130984
      Consensus CDS
      CCDS1917.1
      UniProtKB/Swiss-Prot
      Q14966
      Related
      ENSP00000264447, OTTHUMP00000160151, ENST00000264447, OTTHUMT00000251946
      Conserved Domains (4) summary
      smart00451
      Location:19271959
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:10091082
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:676751
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      pfam07382
      Location:741847
      HC2; Histone H1-like nucleoprotein HC2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      71276543..71435061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017003809.1XP_016859298.1  

    2. XM_011532768.2XP_011531070.2  

    3. XM_017003811.1XP_016859300.1  

    4. XM_017003812.1XP_016859301.1  

      Related
      ENSP00000485608, OTTHUMP00000277889, ENST00000410075, OTTHUMT00000327432
    5. XM_017003810.1XP_016859299.1  

    6. XM_006711989.1XP_006712052.1  

      See identical proteins and their annotated locations for XP_006712052.1

      Conserved Domains (4) summary
      smart00451
      Location:14161448
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:498571
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:165240
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      pfam14259
      Location:167234
      RRM_6; RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)
    7. XM_005264263.1XP_005264320.1  

      See identical proteins and their annotated locations for XP_005264320.1

      Conserved Domains (4) summary
      smart00451
      Location:14161448
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:498571
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:165240
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      pfam14259
      Location:167234
      RRM_6; RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)

    RNA

    1. XR_939678.2 RNA Sequence

    2. XR_001738705.1 RNA Sequence

    3. XR_001738706.1 RNA Sequence

    4. XR_001738707.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      71487646..71591542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)