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BAG3 BCL2-associated athanogene 3 [ Homo sapiens (human) ]

Gene ID: 9531, updated on 6-Jul-2014
Official Symbol
BAG3provided by HGNC
Official Full Name
BCL2-associated athanogene 3provided by HGNC
Primary source
HGNC:939
See related
Ensembl:ENSG00000151929; HPRD:04860; MIM:603883; Vega:OTTHUMG00000019155
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BIS; MFM6; BAG-3; CAIR-1
Summary
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
See BAG3 in Epigenomics, MapViewer
Location:
10q25.2-q26.2
Exon count :
4
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 10 NC_000010.11 (119651347..119677819)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (121410859..121437331)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RAD1 homolog pseudogene 1 Neighboring gene ribosomal protein S8 pseudogene 4 Neighboring gene thioredoxin pseudogene 1 Neighboring gene inositol polyphosphate-5-phosphatase F Neighboring gene phosphatase and actin regulator 2 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy.
NHGRI GWA Catalog
  • Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
    Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chaperone binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
brain development IEA
Inferred from Electronic Annotation
more info
 
cellular response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of striated muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
protein folding NAS
Non-traceable Author Statement
more info
PubMed 
protein stabilization IEA
Inferred from Electronic Annotation
more info
 
spinal cord development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Z disc IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
BAG family molecular chaperone regulator 3
Names
BAG family molecular chaperone regulator 3
docking protein CAIR-1
BCL2-binding athanogene 3
bcl-2-binding protein Bis

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016125.1 

    Range
    5001..31450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004281.3NP_004272.2  BAG family molecular chaperone regulator 3

    See proteins identical to NP_004272.2

    Status: REVIEWED

    Source sequence(s)
    AF071218, BC006418
    Consensus CDS
    CCDS7615.1
    UniProtKB/Swiss-Prot
    O95817
    Related
    ENSP00000358081, OTTHUMP00000020599, ENST00000369085, OTTHUMT00000050662
    Conserved Domains (2) summary
    cd00201
    Location:2353
    Blast Score: 114
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam02179
    Location:424498
    Blast Score: 247
    BAG; BAG domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000010.11 

    Range
    119651347..119677819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270287.1XP_005270344.1  

    Conserved Domains (2) summary
    cd00201
    Location:2353
    Blast Score: 114
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam02179
    Location:423497
    Blast Score: 247
    BAG; BAG domain

Alternate HuRef

Genomic

  1. AC_000142.1 

    Range
    115040288..115066931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 

    Range
    121695782..121722250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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