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PRDX2 peroxiredoxin 2 [ Homo sapiens (human) ]

Gene ID: 7001, updated on 22-Dec-2014
Official Symbol
PRDX2provided by HGNC
Official Full Name
peroxiredoxin 2provided by HGNC
Primary source
HGNC:HGNC:9353
See related
Ensembl:ENSG00000167815; HPRD:02763; MIM:600538; Vega:OTTHUMG00000134285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRP; TSA; PRX2; PTX1; TPX1; NKEFB; PRXII; TDPX1; NKEF-B; HEL-S-2a
Summary
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]
See PRDX2 in Epigenomics, MapViewer
Location:
19p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (12796820..12801910, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12907634..12912724, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene microRNA 5684 Neighboring gene jun B proto-oncogene Neighboring gene ribonuclease H2, subunit A Neighboring gene retbindin

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human peroxiredoxin 2 (PRDX2) at amino acid residues 47-48 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC4104

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antioxidant activity IDA
Inferred from Direct Assay
more info
PubMed 
antioxidant activity NAS
Non-traceable Author Statement
more info
PubMed 
thioredoxin peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
thioredoxin peroxidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
hydrogen peroxide catabolic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
removal of superoxide radicals IDA
Inferred from Direct Assay
more info
PubMed 
response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
peroxiredoxin-2
Names
peroxiredoxin-2
torin
thioredoxin peroxidase 1
thiol-specific antioxidant 1
natural killer cell-enhancing factor B
thioredoxin-dependent peroxide reductase 1
epididymis secretory sperm binding protein Li 2a
NP_005800.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029901.1 

    Range
    4971..10061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005809.5NP_005800.3  peroxiredoxin-2

    See proteins identical to NP_005800.3

    Status: REVIEWED

    Source sequence(s)
    BC000452, BP248561, BQ549456
    Consensus CDS
    CCDS12281.1
    UniProtKB/Swiss-Prot
    P32119
    UniProtKB/TrEMBL
    V9HW12
    Related
    ENSP00000301522, OTTHUMP00000165823, ENST00000301522, OTTHUMT00000258950
    Conserved Domains (2) summary
    COG0450
    Location:7197
    AhpC; Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]
    cd03015
    Location:8179
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    12796820..12801910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    12908110..12913203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    12479370..12484460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181737.1: Suppressed sequence

    Description
    NM_181737.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_181738.1: Suppressed sequence

    Description
    NM_181738.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.