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    CDC14B cell division cycle 14B [ Homo sapiens (human) ]

    Gene ID: 8555, updated on 25-Jul-2015
    Official Symbol
    CDC14Bprovided by HGNC
    Official Full Name
    cell division cycle 14Bprovided by HGNC
    Primary source
    HGNC:HGNC:1719
    See related
    Ensembl:ENSG00000081377; HPRD:04615; MIM:603505; Vega:OTTHUMG00000020300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDC14B3; Cdc14B1; Cdc14B2; hCDC14B
    Summary
    The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
    Orthologs
    See CDC14B in Epigenomics, MapViewer
    Location:
    9q22.3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (96490218..96619830, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (99252807..99382112, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 3 Neighboring gene solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 Neighboring gene NSA2 ribosome biogenesis homolog (S. cerevisiae) pseudogene Neighboring gene zinc finger protein 367 Neighboring gene hyaluronan binding protein 4 Neighboring gene uncharacterized LOC105376163 Neighboring gene uncharacterized LOC105376164 Neighboring gene AhpC/TSA antioxidant enzyme domain containing 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
      MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
    • MAPK6/MAPK4 signaling, organism-specific biosystem (from REACTOME)
      MAPK6/MAPK4 signaling, organism-specific biosystemMAPK6 and MAPK4 (also known as ERK3 and ERK4) are vertebrate-specific atypical MAP kinases. Atypical MAPK are less well characterized than their conventional counterparts, and are generally classifi...
    • PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      PLK1 signaling events, organism-specific biosystem
      PLK1 signaling events
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    G2 DNA damage checkpoint IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of anaphase-promoting complex activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein dephosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    dual specificity protein phosphatase CDC14B
    Names
    CDC14 cell division cycle 14 homolog B
    NP_001070649.1
    NP_003662.1
    NP_201588.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077181.1NP_001070649.1  dual specificity protein phosphatase CDC14B isoform 3

      See identical proteins and their annotated locations for NP_001070649.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate 5' exon, compared to variant 2, resulting in a protein (isoform 3) that has an alternate N-terminus, compared to isoform 2.
      Source sequence(s)
      AK126388, AL133477, DA943563
      Consensus CDS
      CCDS43853.1
      UniProtKB/Swiss-Prot
      O60729
      Conserved Domains (3) summary
      COG2453
      Location:175327
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:15152
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:209323
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. NM_003671.3NP_003662.1  dual specificity protein phosphatase CDC14B isoform 1

      See identical proteins and their annotated locations for NP_003662.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon, compared to variant 2, resulting in a shorter protein (isoform 1) that lacks an internal segment in the C-terminal region, compared to isoform 2.
      Source sequence(s)
      AF064104, AL133477
      Consensus CDS
      CCDS6721.1
      UniProtKB/Swiss-Prot
      O60729
      Related
      ENSP00000413940, OTTHUMP00000215878, ENST00000412285, OTTHUMT00000356341
      Conserved Domains (3) summary
      COG2453
      Location:212364
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:52189
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:246360
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    3. NM_033331.2NP_201588.1  dual specificity protein phosphatase CDC14B isoform 2

      See identical proteins and their annotated locations for NP_201588.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AF064104, AL133477
      Consensus CDS
      CCDS6722.1
      UniProtKB/Swiss-Prot
      O60729
      Related
      ENSP00000364389, OTTHUMP00000021729, ENST00000375241, OTTHUMT00000053278
      Conserved Domains (3) summary
      COG2453
      Location:212364
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:52189
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:246360
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

      Range
      96490218..96619830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519158.1XP_011517460.1  

      See identical proteins and their annotated locations for XP_011517460.1

      UniProtKB/Swiss-Prot
      O60729
      Conserved Domains (3) summary
      COG2453
      Location:212364
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:52189
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:246360
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. XM_011519152.1XP_011517454.1  

      Conserved Domains (3) summary
      COG2453
      Location:305457
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:145282
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:339453
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    3. XM_011519147.1XP_011517449.1  

      Conserved Domains (3) summary
      COG2453
      Location:305457
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:145282
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:339453
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    4. XM_011519149.1XP_011517451.1  

      Conserved Domains (3) summary
      COG2453
      Location:305457
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:145282
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:339453
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    5. XM_011519153.1XP_011517455.1  

      Conserved Domains (3) summary
      COG2453
      Location:305457
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:145282
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:339453
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    6. XM_011519148.1XP_011517450.1  

      Conserved Domains (3) summary
      COG2453
      Location:305457
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:145282
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:339453
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    7. XM_011519150.1XP_011517452.1  

      See identical proteins and their annotated locations for XP_011517452.1

      Conserved Domains (3) summary
      COG2453
      Location:305457
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:145282
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:339453
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    8. XM_005252288.2XP_005252345.1  

      Conserved Domains (3) summary
      COG2453
      Location:175327
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:15152
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:209323
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    9. XM_011519155.1XP_011517457.1  

      Conserved Domains (3) summary
      COG2453
      Location:212364
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:52189
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:246360
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    10. XM_011519156.1XP_011517458.1  

      Conserved Domains (3) summary
      COG2453
      Location:206358
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:47183
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:240354
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    11. XM_011519146.1XP_011517448.1  

      Conserved Domains (3) summary
      COG2453
      Location:305457
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:145282
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:339453
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    12. XM_011519157.1XP_011517459.1  

      Conserved Domains (3) summary
      COG2453
      Location:175327
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:15152
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:209323
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    13. XM_011519159.1XP_011517461.1  

      Conserved Domains (2) summary
      COG2453
      Location:23175
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      cl21483
      Location:57171
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    14. XM_011519154.1XP_011517456.1  

      Conserved Domains (3) summary
      COG2453
      Location:215367
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:57192
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:249363
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    15. XM_011519151.1XP_011517453.1  

      See identical proteins and their annotated locations for XP_011517453.1

      Conserved Domains (3) summary
      COG2453
      Location:305457
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:145282
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:339453
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    16. XM_011519160.1XP_011517462.1  

      Conserved Domains (1) summary
      pfam14671
      Location:145233
      DSPn; Dual specificity protein phosphatase, N-terminal half

    RNA

    1. XR_929866.1 RNA Sequence

    2. XR_929864.1 RNA Sequence

    3. XR_929865.1 RNA Sequence

    4. XR_242602.2 RNA Sequence

    5. XR_929868.1 RNA Sequence

    6. XR_929867.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      99409222..99528933
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_033332.1: Suppressed sequence

      Description
      NM_033332.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.