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TLX1 T-cell leukemia homeobox 1 [ Homo sapiens (human) ]

Gene ID: 3195, updated on 7-Aug-2014
Official Symbol
TLX1provided by HGNC
Official Full Name
T-cell leukemia homeobox 1provided by HGNC
Primary source
HGNC:5056
See related
Ensembl:ENSG00000107807; HPRD:01728; MIM:186770; Vega:OTTHUMG00000019341
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCL3; HOX11
Summary
This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
See TLX1 in Epigenomics, MapViewer
Location:
10q24
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 10 NC_000010.11 (101131304..101137789)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (102891061..102897546)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Kazal-type serine peptidase inhibitor domain 1 Neighboring gene TLX1 neighbor Neighboring gene RNA, Ro-associated Y5 pseudogene 7 Neighboring gene long intergenic non-protein coding RNA 1514

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC163402

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
central nervous system development IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
organ formation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
spleen development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
T-cell leukemia homeobox protein 1
Names
T-cell leukemia homeobox protein 1
proto-oncogene TCL-3
homeobox protein Hox-11
T-cell leukemia/lymphoma protein 3
homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027826.1 

    Range
    5001..11486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195517.1NP_001182446.1  T-cell leukemia homeobox protein 1 isoform 2

    See proteins identical to NP_001182446.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AL357395, BC130530, BF514683
    Consensus CDS
    CCDS55725.1
    UniProtKB/Swiss-Prot
    P31314
    Related
    ENSP00000434914, OTTHUMP00000244108, ENST00000467928, OTTHUMT00000409763
    Conserved Domains (1) summary
    cd00086
    Location:202257
    Blast Score: 211
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. NM_005521.3NP_005512.1  T-cell leukemia homeobox protein 1 isoform 1

    See proteins identical to NP_005512.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC130530, BF514683, M62626, S38742
    Consensus CDS
    CCDS7510.1
    UniProtKB/Swiss-Prot
    P31314
    Conserved Domains (1) summary
    cd00086
    Location:202259
    Blast Score: 213
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000010.11 

    Range
    101131304..101137789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000142.1 

    Range
    96520316..96526784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 

    Range
    103175307..103181792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)