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DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 [ Homo sapiens (human) ]

Gene ID: 1663, updated on 24-Jan-2015
Official Symbol
DDX11provided by HGNC
Official Full Name
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11provided by HGNC
Primary source
HGNC:HGNC:2736
See related
Ensembl:ENSG00000013573; HPRD:03095; MIM:601150; Vega:OTTHUMG00000168435
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHL1; KRG2; WABS; CHLR1
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Orthologs
See DDX11 in MapViewer
Location:
12p11
Exon count:
29
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (31073845..31104799)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (31226779..31257733)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 941 Neighboring gene tetraspanin 11 Neighboring gene DDX11 antisense RNA 1 Neighboring gene putative uncharacterized protein FLJ45355-like Neighboring gene ovostatin 2 Neighboring gene uncharacterized LOC101060088

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat DDX11 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
nucleocapsid gag DDX11 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

  • IRE1alpha activates chaperones, organism-specific biosystem (from REACTOME)
    IRE1alpha activates chaperones, organism-specific biosystemIRE1-alpha is a single-pass transmembrane protein that resides in the endoplasmic reticulum (ER) membrane. The C-terminus of IRE1-alpha is located in the cytosol; the N-terminus is located in the ER ...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Unfolded Protein Response (UPR), organism-specific biosystem (from REACTOME)
    Unfolded Protein Response (UPR), organism-specific biosystemThe Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER d...
  • XBP1(S) activates chaperone genes, organism-specific biosystem (from REACTOME)
    XBP1(S) activates chaperone genes, organism-specific biosystemXbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotri...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC9335, MGC133249

Gene Ontology Provided by GOA

Function Evidence Code Pubs
4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
DNA-dependent ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
activation of signaling protein activity involved in unfolded protein response TAS
Traceable Author Statement
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
endoplasmic reticulum unfolded protein response TAS
Traceable Author Statement
more info
 
sister chromatid cohesion IDA
Inferred from Direct Assay
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
colocalizes_with nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
probable ATP-dependent RNA helicase DDX11
Names
probable ATP-dependent RNA helicase DDX11
KRG-2
hCHLR1
DEAD/H box protein 11
CHL1-related protein 1
CHL1-like helicase homolog
CHL1-related helicase gene-1
keratinocyte growth factor-regulated gene 2 protein
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)
NP_001244073.1
NP_001244074.1
NP_004390.3
NP_085911.2
NP_689651.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023352.1 

    Range
    5001..35947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001257144.1NP_001244073.1  probable ATP-dependent RNA helicase DDX11 isoform 3

    See proteins identical to NP_001244073.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 3 and 4 encode the same protein.
    Source sequence(s)
    AC008013, BC050522
    Consensus CDS
    CCDS44856.1
    UniProtKB/Swiss-Prot
    Q96FC9
    Related
    ENSP00000440402, OTTHUMP00000238784, ENST00000545668, OTTHUMT00000399728
    Conserved Domains (2) summary
    smart00488
    Location:11437
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:710824
    HELICc2; helicase superfamily c-terminal domain
  2. NM_001257145.1NP_001244074.1  probable ATP-dependent RNA helicase DDX11 isoform 4

    See proteins identical to NP_001244074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding region, and uses a downstream AUG compared to variant 3. The resulting protein (isoform 4) has shorter N- and C-termini compared to isoform 3.
    Source sequence(s)
    AC008013, BC050069
    Consensus CDS
    CCDS58224.1
    UniProtKB/Swiss-Prot
    Q96FC9
    Related
    ENSP00000228264, OTTHUMP00000238780, ENST00000228264, OTTHUMT00000399723
    Conserved Domains (3) summary
    smart00488
    Location:1411
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:684841
    HELICc2; helicase superfamily c-terminal domain
    TIGR00604
    Location:201867
    ATP-dependent_RNA_helicase_CHL1; DNA repair helicase (rad3)
  3. NM_004399.2NP_004390.3  probable ATP-dependent RNA helicase DDX11 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate splice junction compared to variant 3, that results in a frameshift. The resulting isoform (2) lacks an internal segment and has a distinct C-terminus compared to isoform 3.
    Source sequence(s)
    BC011264, BC111733, X99583
    Consensus CDS
    CCDS8721.1
    UniProtKB/TrEMBL
    Q2NKM7
    UniProtKB/Swiss-Prot
    Q96FC9
    Related
    ENSP00000309965, OTTHUMP00000238785, ENST00000350437, OTTHUMT00000399729
    Conserved Domains (3) summary
    smart00488
    Location:11437
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:680817
    HELICc2; helicase superfamily c-terminal domain
    TIGR00604
    Location:227843
    ATP-dependent_RNA_helicase_CHL1; DNA repair helicase (rad3)
  4. NM_030653.3NP_085911.2  probable ATP-dependent RNA helicase DDX11 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate splice junction at a coding exon compared to variant 3, that results in a frameshift. The resulting isoform (1) is shorter and has a distinct C-terminus compared to isoform 3.
    Source sequence(s)
    BC011264, BC111733
    Consensus CDS
    CCDS41767.1
    UniProtKB/TrEMBL
    Q2NKM7
    Conserved Domains (3) summary
    smart00488
    Location:11437
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:710867
    HELICc2; helicase superfamily c-terminal domain
    TIGR00604
    Location:227893
    ATP-dependent_RNA_helicase_CHL1; DNA repair helicase (rad3)
  5. NM_152438.1NP_689651.1  probable ATP-dependent RNA helicase DDX11 isoform 3

    See proteins identical to NP_689651.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3). Variants 3 and 4 encode the same protein.
    Source sequence(s)
    BC011264, BC111733
    Consensus CDS
    CCDS44856.1
    UniProtKB/TrEMBL
    Q2NKM7
    UniProtKB/Swiss-Prot
    Q96FC9
    Conserved Domains (2) summary
    smart00488
    Location:11437
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:710824
    HELICc2; helicase superfamily c-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 

    Range
    31073845..31104799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719049.1XP_006719112.1  

    See proteins identical to XP_006719112.1

    Conserved Domains (2) summary
    smart00488
    Location:1411
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:684798
    HELICc2; helicase superfamily c-terminal domain
  2. XM_006719047.1XP_006719110.1  

    See proteins identical to XP_006719110.1

    Conserved Domains (2) summary
    smart00488
    Location:11437
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:710824
    HELICc2; helicase superfamily c-terminal domain
  3. XM_006719053.1XP_006719116.1  

    Conserved Domains (2) summary
    smart00491
    Location:502616
    HELICc2; helicase superfamily c-terminal domain
    cl21455
    Location:20229
    ABC_ATPase; ATP-binding cassette transporter nucleotide-binding domain
  4. XM_006719044.1XP_006719107.1  

    See proteins identical to XP_006719107.1

    Conserved Domains (2) summary
    smart00488
    Location:11437
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:710824
    HELICc2; helicase superfamily c-terminal domain
  5. XM_006719048.1XP_006719111.1  

    See proteins identical to XP_006719111.1

    Conserved Domains (2) summary
    smart00488
    Location:1411
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:684798
    HELICc2; helicase superfamily c-terminal domain
  6. XM_006719045.1XP_006719108.1  

    See proteins identical to XP_006719108.1

    Conserved Domains (2) summary
    smart00488
    Location:11437
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:710824
    HELICc2; helicase superfamily c-terminal domain
  7. XM_006719041.1XP_006719104.1  

    See proteins identical to XP_006719104.1

    Conserved Domains (2) summary
    smart00488
    Location:47473
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:746860
    HELICc2; helicase superfamily c-terminal domain
  8. XM_006719042.1XP_006719105.1  

    See proteins identical to XP_006719105.1

    Conserved Domains (2) summary
    smart00488
    Location:47473
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:746860
    HELICc2; helicase superfamily c-terminal domain
  9. XM_006719046.1XP_006719109.1  

    See proteins identical to XP_006719109.1

    Conserved Domains (2) summary
    smart00488
    Location:11437
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:710824
    HELICc2; helicase superfamily c-terminal domain
  10. XM_006719050.1XP_006719113.1  

    Conserved Domains (3) summary
    smart00488
    Location:47473
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:746903
    HELICc2; helicase superfamily c-terminal domain
    TIGR00604
    Location:263929
    ATP-dependent_RNA_helicase_CHL1; DNA repair helicase (rad3)
  11. XM_005253331.1XP_005253388.1  

    Conserved Domains (2) summary
    smart00488
    Location:47473
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:746860
    HELICc2; helicase superfamily c-terminal domain
  12. XM_006719051.1XP_006719114.1  

    Conserved Domains (3) summary
    smart00488
    Location:47473
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:746890
    HELICc2; helicase superfamily c-terminal domain
    TIGR00604
    Location:263916
    ATP-dependent_RNA_helicase_CHL1; DNA repair helicase (rad3)
  13. XM_006719043.1XP_006719106.1  

    Conserved Domains (2) summary
    smart00488
    Location:47473
    DEXDc2; DEAD-like helicases superfamily
    cl21455
    Location:746847
    ABC_ATPase; ATP-binding cassette transporter nucleotide-binding domain
  14. XM_005253333.1XP_005253390.1  

    Conserved Domains (3) summary
    smart00488
    Location:47473
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:746903
    HELICc2; helicase superfamily c-terminal domain
    TIGR00604
    Location:263929
    ATP-dependent_RNA_helicase_CHL1; DNA repair helicase (rad3)
  15. XM_006719052.1XP_006719115.1  

    Conserved Domains (2) summary
    smart00488
    Location:47473
    DEXDc2; DEAD-like helicases superfamily
    cl21455
    Location:746836
    ABC_ATPase; ATP-binding cassette transporter nucleotide-binding domain

RNA

  1. XR_429031.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 

    Range
    31191725..31222687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000144.1 

    Range
    30992012..31022870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030655.2: Suppressed sequence

    Description
    NM_030655.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.