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    DPM3 dolichyl-phosphate mannosyltransferase subunit 3 [ Homo sapiens (human) ]

    Gene ID: 54344, updated on 14-Apr-2016
    Official Symbol
    DPM3provided by HGNC
    Official Full Name
    dolichyl-phosphate mannosyltransferase subunit 3provided by HGNC
    Primary source
    HGNC:HGNC:3007
    See related
    Ensembl:ENSG00000179085 HPRD:16179; MIM:605951; Vega:OTTHUMG00000035335
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDG1O
    Summary
    Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    1q22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (155139891..155140520, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155112367..155112996, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ephrin A1 Neighboring gene solute carrier family 50 member 1 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 18 Neighboring gene keratinocyte associated protein 2

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
    NHGRI GWA Catalog
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC34275, MGC125904, MGC125905

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to dolichyl-phosphate beta-D-mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    GPI anchor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GPI anchor biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    carbohydrate metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan TAS
    Traceable Author Statement
    more info
    PubMed 
    protein N-linked glycosylation via asparagine TAS
    Traceable Author Statement
    more info
     
    protein O-linked mannosylation TAS
    Traceable Author Statement
    more info
    PubMed 
    protein mannosylation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of protein stability IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    dolichol-phosphate-mannose synthase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    integral component of endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mannosyltransferase complex TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    dolichol-phosphate mannosyltransferase subunit 3
    Names
    DPM synthase complex subunit 3
    DPM synthase subunit 3
    MPD synthase subunit 3
    dolichol-phosphate mannose synthase subunit 3
    dolichyl-phosphate beta-D-mannosyltransferase subunit 3
    dolichyl-phosphate mannosyltransferase polypeptide 3
    mannose-P-dolichol synthase subunit 3
    prostin 1
    prostin-1
    testicular tissue protein Li 58
    NP_061846.2
    NP_714963.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012871.1 RefSeqGene

      Range
      5001..5630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_018973.3NP_061846.2  dolichol-phosphate mannosyltransferase subunit 3 isoform 1

      See identical proteins and their annotated locations for NP_061846.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF312922
      Consensus CDS
      CCDS1094.1
      UniProtKB/Swiss-Prot
      Q9P2X0
      Related
      ENSP00000357384, OTTHUMP00000033285, ENST00000368399, OTTHUMT00000085520
      Conserved Domains (1) summary
      pfam08285
      Location:31122
      DPM3; Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
    2. NM_153741.1NP_714963.1  dolichol-phosphate mannosyltransferase subunit 3 isoform 2

      See identical proteins and their annotated locations for NP_714963.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and 5' coding region, compared to variant 1. This results in translation initiation from a downstream ATG and an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      BC032223
      Consensus CDS
      CCDS1095.1
      UniProtKB/Swiss-Prot
      Q9P2X0
      UniProtKB/TrEMBL
      Q86TM7
      Related
      ENSP00000357385, OTTHUMP00000033283, ENST00000368400, OTTHUMT00000085518
      Conserved Domains (1) summary
      pfam08285
      Location:192
      DPM3; Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

      Range
      155139891..155140520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      156508106..156508735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)