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MUS81 MUS81 structure-specific endonuclease subunit [ Homo sapiens (human) ]

Gene ID: 80198, updated on 13-Jan-2015
Official Symbol
MUS81provided by HGNC
Official Full Name
MUS81 structure-specific endonuclease subunitprovided by HGNC
Primary source
HGNC:HGNC:29814
See related
Ensembl:ENSG00000172732; HPRD:09419; MIM:606591; Vega:OTTHUMG00000166633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLX3
Orthologs
See MUS81 in MapViewer
Location:
11q13
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (65860401..65866443)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65627872..65633914)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene sorting nexin 32 Neighboring gene cofilin 1 (non-muscle) Neighboring gene EGF containing fibulin-like extracellular matrix protein 2 Neighboring gene cathepsin W Neighboring gene fibroblast growth factor (acidic) intracellular binding protein Neighboring gene coiled-coil domain containing 85B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of MUS81 endonuclease homolog (S. cerevisiae, MUS81) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr VPRBP is required for HIV-1 Vpr-mediated activation of the SLX4 complex and modulation of MUS81 levels. The interaction between Vpr and VPRBP is involved in MUS81 ubiquitination PubMed
vpr HIV-1 Vpr induces untimely activation of SLX4-associated MUS81-EME1 through phosphorylation of EME1 by PLK1 PubMed
vpr Co-immunoprecipitation and glycerol-gradient sedimentation demonstrate that HIV-1 Vpr, VPRBP, DDB1, SLX4, MUS81, EME1, ERCC1, and ERCC4 form a complex PubMed

Go to the HIV-1, Human Interaction Database

  • Fanconi anemia pathway, organism-specific biosystem (from KEGG)
    Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
  • Fanconi anemia pathway, conserved biosystem (from KEGG)
    Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
  • Homologous recombination, organism-specific biosystem (from KEGG)
    Homologous recombination, organism-specific biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
  • Homologous recombination, conserved biosystem (from KEGG)
    Homologous recombination, conserved biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ21012, FLJ44872

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-flap endonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA catabolic process, endonucleolytic IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA recombination IEA
Inferred from Electronic Annotation
more info
 
DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to intra-S DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
crossover junction endonuclease MUS81
Names
crossover junction endonuclease MUS81
MUS81 endonuclease homolog
SLX3 structure-specific endonuclease subunit homolog
NP_079404.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025128.4NP_079404.3  crossover junction endonuclease MUS81

    See proteins identical to NP_079404.3

    Status: VALIDATED

    Source sequence(s)
    AK223564, BC009999, BI816797, DA449863
    Consensus CDS
    CCDS8115.1
    UniProtKB/TrEMBL
    Q53ES5
    UniProtKB/Swiss-Prot
    Q96NY9
    Related
    ENSP00000307853, OTTHUMP00000233868, ENST00000308110, OTTHUMT00000390941
    Conserved Domains (2) summary
    COG1948
    Location:261515
    MUS81; ERCC4-type nuclease [DNA replication, recombination, and repair]
    pfam02732
    Location:273415
    ERCC4; ERCC4 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    65860401..65866443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274307.1XP_005274364.1  

    See proteins identical to XP_005274364.1

    Conserved Domains (2) summary
    COG1948
    Location:261516
    MUS81; ERCC4-type nuclease [DNA replication, recombination, and repair]
    pfam02732
    Location:273416
    ERCC4; ERCC4 domain

RNA

  1. XR_247212.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    65512285..65518328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    61954389..61960431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)