Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    MYO5B myosin VB [ Homo sapiens (human) ]

    Gene ID: 4645, updated on 3-Jan-2016
    Official Symbol
    MYO5Bprovided by HGNC
    Official Full Name
    myosin VBprovided by HGNC
    Primary source
    HGNC:HGNC:7603
    See related
    Ensembl:ENSG00000167306; MIM:606540; Vega:OTTHUMG00000179843
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene, together with other proteins, may be involved in plasma membrane recycling. Mutations in this gene are associated with microvillous inclusion disease. [provided by RefSeq, Sep 2009]
    Orthologs
    See MYO5B in Epigenomics, MapViewer
    Location:
    18q21
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 18 NC_000018.10 (49822786..50195081, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (47349156..47721542, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene acetyl-CoA acyltransferase 2 Neighboring gene small Cajal body-specific RNA 17 Neighboring gene small nucleolar RNA host gene 22 Neighboring gene RNA, 5S ribosomal pseudogene 457 Neighboring gene adenosine deaminase domain containing 1 pseudogene 2 Neighboring gene uncharacterized LOC105372113 Neighboring gene microRNA 4320 Neighboring gene uncharacterized LOC105376869 Neighboring gene cilia and flagella associated protein 53 Neighboring gene methyl-CpG binding domain protein 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA1119

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    Rab GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    microfilament motor activity TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    endosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    renal water homeostasis TAS
    Traceable Author Statement
    more info
     
    transmembrane transport TAS
    Traceable Author Statement
    more info
     
    vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    water transport TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    apical cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with recycling endosome IC
    Inferred by Curator
    more info
    PubMed 
    Preferred Names
    unconventional myosin-Vb
    Names
    MYO5B variant protein
    myosin-Vb

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012925.1 RefSeqGene

      Range
      5001..377296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001080467.2NP_001073936.1  unconventional myosin-Vb

      See identical proteins and their annotated locations for NP_001073936.1

      Status: REVIEWED

      Source sequence(s)
      AB290160, AK025336, AY274809, BC032511, BX641287, DA350416, Z38208
      Consensus CDS
      CCDS42436.1
      UniProtKB/TrEMBL
      Q7Z7A5
      UniProtKB/Swiss-Prot
      Q9ULV0
      Related
      ENSP00000285039, OTTHUMP00000262724, ENST00000285039, OTTHUMT00000448515
      Conserved Domains (6) summary
      smart00015
      Location:860881
      IQ; Calmodulin-binding motif
      smart00242
      Location:64760
      MYSc; Myosin. Large ATPases
      pfam15619
      Location:8951073
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      cd15477
      Location:14741845
      Myo5b_CBD; Cargo binding domain of myosin 5b
      cl18042
      Location:9651074
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cd01380
      Location:83749
      MYSc_Myo5; class V myosin, motor domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p2 Primary Assembly

      Range
      49822786..50195081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018929.2 Alternate CHM1_1.1

      Range
      47344771..47717073 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)