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    VPS35 VPS35 retromer complex component [ Homo sapiens (human) ]

    Gene ID: 55737, updated on 30-Jun-2015
    Official Symbol
    VPS35provided by HGNC
    Official Full Name
    VPS35 retromer complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:13487
    See related
    HPRD:06085; MIM:601501
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MEM3; PARK17
    Summary
    This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]
    Orthologs
    See VPS35 in Epigenomics, MapViewer
    Location:
    16q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (46657995..46689232, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (46693589..46723144, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene SHC SH2-domain binding protein 1 Neighboring gene RAB43 pseudogene 1 Neighboring gene origin recognition complex, subunit 6 Neighboring gene myosin light chain kinase 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env The gp41 cytoplasmic tail binds directly to retromer components VPS26 and VPS35 in HIV-1-infected cells PubMed
    Tat tat Expression of HIV-1 Tat upregulates the abundance of vacuolar protein sorting 35 homolog (VPS35) in the nucleoli of Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Clone Names

    • FLJ10752, FLJ13588, FLJ20388, DKFZp434E1211, DKFZp434P1672

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of late endosome to lysosome transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retrograde transport, endosome to Golgi IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retrograde transport, endosome to Golgi NAS
    Non-traceable Author Statement
    more info
    PubMed 
    retrograde transport, endosome to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    retromer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    tubular endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    vacuolar protein sorting-associated protein 35
    Names
    hVPS35
    maternal-embryonic 3
    vacuolar protein sorting 35 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029970.1 RefSeqGene

      Range
      5001..34556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_018206.4NP_060676.2  vacuolar protein sorting-associated protein 35

      See identical proteins and their annotated locations for NP_060676.2

      Status: REVIEWED

      Source sequence(s)
      BC093036, BM971213, BQ574179, DB049686
      Consensus CDS
      CCDS10721.1
      UniProtKB/Swiss-Prot
      Q96QK1
      Conserved Domains (1) summary
      pfam03635
      Location:14754
      Vps35; Vacuolar protein sorting-associated protein 35

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

      Range
      46657995..46689232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005256045.2XP_005256102.1  

      See identical proteins and their annotated locations for XP_005256102.1

      Conserved Domains (1) summary
      pfam03635
      Location:1687
      Vps35; Vacuolar protein sorting-associated protein 35
    2. XM_011523227.1XP_011521529.1  

      See identical proteins and their annotated locations for XP_011521529.1

      Conserved Domains (1) summary
      pfam03635
      Location:1725
      Vps35; Vacuolar protein sorting-associated protein 35

    Alternate CHM1_1.1

    Genomic

    1. NC_018927.2 Alternate CHM1_1.1

      Range
      48100524..48130101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)