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SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin [ Homo sapiens (human) ]

Gene ID: 6614, updated on 7-Dec-2014
Official Symbol
SIGLEC1provided by HGNC
Official Full Name
sialic acid binding Ig-like lectin 1, sialoadhesinprovided by HGNC
Primary source
HGNC:HGNC:11127
See related
Ensembl:ENSG00000088827; HPRD:02854; MIM:600751; Vega:OTTHUMG00000031757
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SN; CD169; SIGLEC-1; dJ1009E24.1
Summary
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
See SIGLEC1 in Epigenomics, MapViewer
Location:
20p13
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 20 NC_000020.11 (3686970..3712566, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3667617..3693213, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene GDNF family receptor alpha 4 Neighboring gene ADAM metallopeptidase domain 33 Neighboring gene heat shock 70kD protein 12B Neighboring gene chromosome 20 open reading frame 27

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Interferon-alpha- and interferon-gamma-induced sialoadhesin-expressing monocytes adsorb HIV-1 through interaction with the sialic acid residues on the viral envelope glycoprotein gp120 PubMed
Pr55(Gag) gag HIV-1 Gag co-localizes with Siglec-1 in the sac-like compartment PubMed

Go to the HIV-1, Human Interaction Database

  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ00051, FLJ00055, FLJ00073, FLJ00411, FLJ32150, DKFZp667F058

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell-matrix adhesion NAS
Non-traceable Author Statement
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of T cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
single organismal cell-cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
sialoadhesin
Names
sialoadhesin
sialic acid-binding Ig-like lectin 1
sialic acid-binding immunoglobulin-like lectin 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023068.3NP_075556.1  sialoadhesin precursor

    See proteins identical to NP_075556.1

    Status: REVIEWED

    Source sequence(s)
    AF230073, AK024462, AY927519, CD365566
    Consensus CDS
    CCDS13060.1
    UniProtKB/Swiss-Prot
    Q9BZZ2
    Related
    ENSP00000341141, OTTHUMP00000030124, ENST00000344754, OTTHUMT00000077761
    Conserved Domains (8) summary
    cd00096
    Location:430503
    Ig; Immunoglobulin domain
    smart00408
    Location:254312
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:10931168
    IG; Immunoglobulin
    smart00410
    Location:516594
    IG_like; Immunoglobulin like
    pfam07679
    Location:898980
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:142228
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:245323
    Ig_2; Immunoglobulin domain
    cl11960
    Location:21136
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 

    Range
    3686970..3712566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723612.1XP_006723675.1  

    Conserved Domains (8) summary
    cd00096
    Location:430503
    Ig; Immunoglobulin domain
    smart00408
    Location:254312
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:10071082
    IG; Immunoglobulin
    smart00410
    Location:338408
    IG_like; Immunoglobulin like
    pfam07679
    Location:812894
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:142228
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:245323
    Ig_2; Immunoglobulin domain
    cl11960
    Location:21136
    Ig; Immunoglobulin domain
  2. XM_006723611.1XP_006723674.1  

    UniProtKB/Swiss-Prot
    Q9BZZ2
    Conserved Domains (8) summary
    cd00096
    Location:430503
    Ig; Immunoglobulin domain
    smart00408
    Location:254312
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:10931168
    IG; Immunoglobulin
    smart00410
    Location:516594
    IG_like; Immunoglobulin like
    pfam07679
    Location:898980
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:142228
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:245323
    Ig_2; Immunoglobulin domain
    cl11960
    Location:21136
    Ig; Immunoglobulin domain
  3. XM_006723610.1XP_006723673.1  

    See proteins identical to XP_006723673.1

    UniProtKB/Swiss-Prot
    Q9BZZ2
    Conserved Domains (8) summary
    cd00096
    Location:430503
    Ig; Immunoglobulin domain
    smart00408
    Location:254312
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:10931168
    IG; Immunoglobulin
    smart00410
    Location:516594
    IG_like; Immunoglobulin like
    pfam07679
    Location:898980
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:142228
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:245323
    Ig_2; Immunoglobulin domain
    cl11960
    Location:21136
    Ig; Immunoglobulin domain
  4. XM_006723613.1XP_006723676.1  

    Conserved Domains (7) summary
    cd00096
    Location:106179
    Ig; Immunoglobulin domain
    smart00408
    Location:9491007
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:769844
    IG; Immunoglobulin
    smart00410
    Location:192270
    IG_like; Immunoglobulin like
    pfam07679
    Location:574656
    I-set; Immunoglobulin I-set domain
    pfam13895
    Location:576656
    Ig_2; Immunoglobulin domain
    cl11960
    Location:12281306
    Ig; Immunoglobulin domain

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 

    Range
    3667931..3688082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000152.1 

    Range
    3615947..3636103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)