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    ATG4C autophagy related 4C cysteine peptidase [ Homo sapiens (human) ]

    Gene ID: 84938, updated on 19-Jul-2016
    Official Symbol
    ATG4Cprovided by HGNC
    Official Full Name
    autophagy related 4C cysteine peptidaseprovided by HGNC
    Primary source
    HGNC:HGNC:16040
    See related
    Ensembl:ENSG00000125703 HPRD:07473; MIM:611339; Vega:OTTHUMG00000009142
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APG4C; AUTL1; AUTL3; APG4-C
    Summary
    Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    1p31.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (62784106..62865270)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (63249777..63330941)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 7 Neighboring gene angiopoietin like 3 Neighboring gene ribosomal protein L13a pseudogene 9 Neighboring gene uncharacterized LOC105378769 Neighboring gene uncharacterized LOC105378770 Neighboring gene long intergenic non-protein coding RNA 466 Neighboring gene RNA, 5S ribosomal pseudogene 49

    NHGRI GWAS Catalog

    Description
    Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
    NHGRI GWA Catalog
    Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
    NHGRI GWA Catalog
    Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif binds more strongly to autophagy-related protein 4 (ATG4)-cleaved form I (LC3-I) than to ATG4-cleaved form II (LC3-II) in an A3G-independent manner PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ14867

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    C-terminal protein lipidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    autophagosome assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    autophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein delipidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein targeting to membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    cysteine protease ATG4C
    Names
    APG4 autophagy 4 homolog C
    ATG4 autophagy related 4 homolog C
    AUT-like 1, cysteine endopeptidase
    AUT-like 3 cysteine endopeptidase
    autophagin-3
    autophagy related 4C, cysteine peptidase
    autophagy-related cysteine endopeptidase 3
    autophagy-related protein 4 homolog C

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032852.3NP_116241.2  cysteine protease ATG4C

      See identical proteins and their annotated locations for NP_116241.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the predominant transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC033024, BI518482, BM146035, BQ777265, DB183325
      Consensus CDS
      CCDS623.1
      UniProtKB/Swiss-Prot
      Q96DT6
      Related
      ENSP00000322159, OTTHUMP00000010714, ENST00000317868, OTTHUMT00000025332
      Conserved Domains (1) summary
      pfam03416
      Location:73402
      Peptidase_C54; Peptidase family C54
    2. NM_178221.2NP_835739.1  cysteine protease ATG4C

      See identical proteins and their annotated locations for NP_835739.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR as compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC008395, BC033024, BM146035, BM720875, BQ777265, DB183325
      Consensus CDS
      CCDS623.1
      UniProtKB/Swiss-Prot
      Q96DT6
      Related
      ENSP00000360161, OTTHUMP00000010715, ENST00000371120, OTTHUMT00000025333
      Conserved Domains (1) summary
      pfam03416
      Location:73402
      Peptidase_C54; Peptidase family C54

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      62784106..62865270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002601.1XP_016858090.1  

    2. XM_017002600.1XP_016858089.1  

    3. XM_011542313.2XP_011540615.1  

      Conserved Domains (1) summary
      pfam03416
      Location:73402
      Peptidase_C54; Peptidase family C54
    4. XM_005271288.2XP_005271345.1  

      See identical proteins and their annotated locations for XP_005271345.1

      UniProtKB/Swiss-Prot
      Q96DT6
      Conserved Domains (1) summary
      pfam03416
      Location:73402
      Peptidase_C54; Peptidase family C54

    RNA

    1. XR_001737493.1 RNA Sequence

    2. XR_001737494.1 RNA Sequence

    3. XR_001737492.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      63364721..63446306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)