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SEC16A SEC16 homolog A (S. cerevisiae) [ Homo sapiens (human) ]

Gene ID: 9919, updated on 24-Jan-2015
Official Symbol
SEC16Aprovided by HGNC
Official Full Name
SEC16 homolog A (S. cerevisiae)provided by HGNC
Primary source
HGNC:HGNC:29006
Locus tag
RP11-413M3.10
See related
Ensembl:ENSG00000148396; MIM:612854; Vega:OTTHUMG00000020932
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p250; SEC16L; KIAA0310
Summary
This gene encodes a protein that forms part of the Sec16 complex. This protein has a role in protein transport from the endoplasmic reticulum (ER) to the Golgi and mediates COPII vesicle formation at the transitional ER. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Feb 2013]
Orthologs
See SEC16A in MapViewer
Location:
9q34.3
Exon count:
34
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 9 NC_000009.12 (136440096..136484840, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139334548..139379297, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene serologically defined colon cancer antigen 3 Neighboring gene peptidase (mitochondrial processing) alpha Neighboring gene inositol polyphosphate-5-phosphatase, 72 kDa Neighboring gene chromosome 9 open reading frame 163 Neighboring gene notch 1 Neighboring gene microRNA 4673 Neighboring gene long intergenic non-protein coding RNA 1573 Neighboring gene microRNA 4674

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ26737, KIAA0310

Gene Ontology Provided by GOA

Process Evidence Code Pubs
COPII vesicle coating IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum organization IDA
Inferred from Direct Assay
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
substantia nigra development IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein transport protein Sec16A
Names
protein transport protein Sec16A
protein SEC16 homolog A
NP_001263347.1
NP_055681.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276418.1NP_001263347.1  protein transport protein Sec16A isoform 2

    See proteins identical to NP_001263347.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks two alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AB002308, AB593115, BC070488, BM975558
    Consensus CDS
    CCDS75936.1
    UniProtKB/TrEMBL
    F1T0I1
    UniProtKB/Swiss-Prot
    O15027
    Related
    ENSP00000290037, ENST00000290037
    Conserved Domains (1) summary
    cd09233
    Location:14971859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  2. NM_014866.1NP_055681.1  protein transport protein Sec16A isoform 1

    See proteins identical to NP_055681.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB002308, BM975558
    Consensus CDS
    CCDS55351.1
    UniProtKB/TrEMBL
    J3KNL6
    UniProtKB/Swiss-Prot
    O15027
    Related
    ENSP00000325827, ENST00000313050
    Conserved Domains (1) summary
    cd09233
    Location:14971859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000009.12 

    Range
    136440096..136484840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266136.2XP_005266193.1  

    Conserved Domains (1) summary
    cd09233
    Location:14081770
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  2. XM_005266133.2XP_005266190.1  

    Conserved Domains (1) summary
    cd09233
    Location:16452007
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  3. XM_005266132.2XP_005266189.1  

    Conserved Domains (1) summary
    cd09233
    Location:16452007
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  4. XM_005266134.1XP_005266191.1  

    See proteins identical to XP_005266191.1

    Conserved Domains (1) summary
    cd09233
    Location:14971859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  5. XM_005266137.2XP_005266194.1  

    See proteins identical to XP_005266194.1

    Conserved Domains (1) summary
    cd09233
    Location:14971859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 

    Range
    139482991..139526945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000141.1 

    Range
    108793635..108837485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)