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    CDK7 cyclin-dependent kinase 7 [ Homo sapiens (human) ]

    Gene ID: 1022, updated on 24-Aug-2015
    Official Symbol
    CDK7provided by HGNC
    Official Full Name
    cyclin-dependent kinase 7provided by HGNC
    Primary source
    HGNC:HGNC:1778
    See related
    Ensembl:ENSG00000134058; HPRD:15993; MIM:601955; Vega:OTTHUMG00000099358
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAK1; HCAK; MO15; STK1; CDKN7; p39MO15
    Summary
    The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]
    Orthologs
    See CDK7 in Epigenomics, MapViewer
    Location:
    5q12.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (69234795..69277430)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (68530622..68573257)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene centromere protein H Neighboring gene mitochondrial ribosomal protein S36 Neighboring gene coiled-coil domain containing 125 Neighboring gene cofilin 1 (non-muscle) pseudogene 5 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme and transcription preinitiation complexes, which include TFIIH, during Tat-mediated transactivation of the HIV-1 LTR PubMed
    tat TFIIH subunits CDK7 and cyclin H have been identified as two components associated with the Tat-associated CTD kinase (TTK) that binds to HIV-1 Tat PubMed
    tat Phosphorylation of CDK7 by CDK2 is involved in the interaction of HIV-1 Tat with CDK7 and subsequent activation of HIV-1 transactivation of the HIV-1 LTR promoter PubMed
    tat TFIIH synergizes with HIV-1 Tat to induce transcription elongation from the HIV-1 LTR promoter PubMed
    tat Interaction of HIV-1 Tat with TFIIH stimulates phosphorylation of Ser-5 of the RNA polymerase II C-terminal domain (CTD), which in turn also stimulates co-transcriptional capping of HIV-1 mRNA PubMed
    tat TFIIH interacts with HIV-1 Tat as a component of the HIV-1 transcription preinitiation complex, but is released from the elongation complex which includes P-TEFb PubMed
    tat CAK/TFIIH is required for HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter PubMed
    tat Amino acids 1-48 of HIV-1 Tat, which includes the Tat activation domain, mediate the binding of Tat to CAK and the TFIIH complex through a direct interaction with CDK7 and possibly other TFIIH subunits, including p62 and ERCC3 PubMed
    Vpr vpr As a component of the TFIIH transcription complex, CDK7 inhibits HIV-1 Vpr cell cycle-arresting function PubMed
    vpr As a component of the TFIIH transcription complex, CDK7 enhances the synergistic activation of glucocorticoid receptor by HIV-1 Vpr and p300 PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-dependent ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II carboxy-terminal domain kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    androgen receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    7-methylguanosine mRNA capping TAS
    Traceable Author Statement
    more info
     
    DNA repair TAS
    Traceable Author Statement
    more info
     
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    androgen receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell cycle arrest TAS
    Traceable Author Statement
    more info
    PubMed 
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    gene expression TAS
    Traceable Author Statement
    more info
     
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    negative regulation of gene expression, epigenetic TAS
    Traceable Author Statement
    more info
     
    nucleotide-excision repair TAS
    Traceable Author Statement
    more info
     
    nucleotide-excision repair, DNA damage removal TAS
    Traceable Author Statement
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of viral transcription TAS
    Traceable Author Statement
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cyclin-dependent protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of gene expression, epigenetic TAS
    Traceable Author Statement
    more info
     
    termination of RNA polymerase I transcription TAS
    Traceable Author Statement
    more info
     
    transcription elongation from RNA polymerase I promoter TAS
    Traceable Author Statement
    more info
     
    transcription elongation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    transcription from RNA polymerase I promoter TAS
    Traceable Author Statement
    more info
     
    transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    transcription initiation from RNA polymerase I promoter TAS
    Traceable Author Statement
    more info
     
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    transcription-coupled nucleotide-excision repair TAS
    Traceable Author Statement
    more info
     
    viral process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    holo TFIIH complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    cyclin-dependent kinase 7
    Names
    39 KDa protein kinase
    CAK
    CDK-activating kinase 1
    TFIIH basal transcription factor complex kinase subunit
    cell division protein kinase 7
    cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)
    homolog of Xenopus MO15 Cdk-activating kinase
    kinase subunit of CAK
    p39 Mo15
    protein kinase
    serine/threonine kinase stk1
    serine/threonine protein kinase 1
    serine/threonine protein kinase MO15
    serine/threonine-protein kinase 1
    NP_001790.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001799.3NP_001790.1  cyclin-dependent kinase 7

      See identical proteins and their annotated locations for NP_001790.1

      Status: VALIDATED

      Source sequence(s)
      BC000834, BC005298, BI520184, CA437275
      Consensus CDS
      CCDS3999.1
      UniProtKB/Swiss-Prot
      P50613
      Related
      ENSP00000256443, OTTHUMP00000125195, ENST00000256443, OTTHUMT00000216802
      Conserved Domains (2) summary
      PTZ00024
      Location:7308
      PTZ00024; cyclin-dependent protein kinase; Provisional
      cd07841
      Location:11308
      STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

      Range
      69234795..69277430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543094.1XP_011541396.1  

      Conserved Domains (1) summary
      cl21453
      Location:1191
      PKc_like; Protein Kinases, catalytic domain
    2. XM_011543093.1XP_011541395.1  

      See identical proteins and their annotated locations for XP_011541395.1

      Conserved Domains (2) summary
      PTZ00024
      Location:7251
      PTZ00024; cyclin-dependent protein kinase; Provisional
      cd07841
      Location:11251
      STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
    3. XM_005248398.3XP_005248455.1  

      See identical proteins and their annotated locations for XP_005248455.1

      Conserved Domains (1) summary
      cl21453
      Location:43251
      PKc_like; Protein Kinases, catalytic domain

    Reference GRCh38.p2 ALT_REF_LOCI_1

    Genomic

    1. NW_003315917.2 Reference GRCh38.p2 ALT_REF_LOCI_1

      Range
      17975..60596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011546944.1XP_011545246.1  

      See identical proteins and their annotated locations for XP_011545246.1

      Conserved Domains (2) summary
      PTZ00024
      Location:7251
      PTZ00024; cyclin-dependent protein kinase; Provisional
      cd07841
      Location:11251
      STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
    2. XM_005276756.3XP_005276813.1  

      See identical proteins and their annotated locations for XP_005276813.1

      Conserved Domains (1) summary
      cl21453
      Location:43251
      PKc_like; Protein Kinases, catalytic domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      68530362..68573002
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)