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    UBE2N ubiquitin-conjugating enzyme E2N [ Homo sapiens (human) ]

    Gene ID: 7334, updated on 5-Jul-2015
    Official Symbol
    UBE2Nprovided by HGNC
    Official Full Name
    ubiquitin-conjugating enzyme E2Nprovided by HGNC
    Primary source
    HGNC:HGNC:12492
    See related
    HPRD:04725; MIM:603679
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBC13; UbcH13; HEL-S-71; UbcH-ben; UBCHBEN; UBC13
    Summary
    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]
    Orthologs
    See UBE2N in Epigenomics, MapViewer
    Location:
    12q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (93408312..93443445, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (93802088..93836026, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC643339 Neighboring gene uncharacterized LOC102724933 Neighboring gene uncharacterized LOC105369910 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 4 Neighboring gene mitochondrial ribosomal protein L42 Neighboring gene SOCS2 antisense RNA 1 Neighboring gene suppressor of cytokine signaling 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Many sequence variants affecting diversity of adult human height.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag Heterodimeric E2 UBC13-UEV1A and the arginine 63-linked ubiquitin chains play a role in TRIM5alpha-mediated signaling, which leads to capsid-specific restriction PubMed

    Go to the HIV-1, Human Interaction Database

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    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
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    • C-type lectin receptors (CLRs), organism-specific biosystem (from REACTOME)
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      Cell Cycle, organism-specific biosystem
      Cell Cycle
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      G2/M Checkpoints, organism-specific biosystemG2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they f...
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      G2/M DNA damage checkpoint, organism-specific biosystemThroughout the cell cycle, the genome is constantly monitored for damage, resulting either from errors of replication, by-products of metabolism or through extrinsic sources such as ultra-violet or i...
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    • IL1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL1-mediated signaling events, organism-specific biosystem
      IL1-mediated signaling events
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      IRAK1 recruits IKK complex, organism-specific biosystemThe role of IRAK1 kinase activity in the activation of NF-kappa-B by IL-1/TLR is still uncertain. It has been shown that a kinase-dead IRAK1 mutants can still activate NF-kappa-B. Furthermore, stimu...
    • IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, organism-specific biosystem (from REACTOME)
      IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, organism-specific biosystemThe role of IRAK1 kinase activity in the activation of NF-kappa-B by IL-1/TLR is still uncertain. It has been shown that a kinase-dead IRAK1 mutants can still activate NF-kappa-B. Furthermore, stimu...
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    • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
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    • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
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      TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling, organism-specific biosystemIn plasmacytoid dendritic cell induction of type I IFNs critically depends on IFN regulatory factor 7 in TLR7 and 9 signaling (Honda et al 2005). IRF-7, but not IRF3, interacts with MyD88, TRAF6, and...
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      TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemTRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
    • TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
      TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemTRIF(TICAM1) was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists...
    • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
    • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
    • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
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      Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
    • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
    • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
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    • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
    • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
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    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC8489, MGC131857

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA double-strand break processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Fc-epsilon receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    MyD88-dependent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    cellular protein modification process TAS
    Traceable Author Statement
    more info
    PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    innate immune response TAS
    Traceable Author Statement
    more info
     
    nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    nucleotide-binding oligomerization domain containing signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling TAS
    Traceable Author Statement
    more info
     
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of histone modification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    postreplication repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein K63-linked ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein ubiquitination TAS
    Traceable Author Statement
    more info
    PubMed 
    proteolysis TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of DNA repair TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of histone ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stimulatory C-type lectin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    toll-like receptor 10 signaling pathway TAS
    Traceable Author Statement
    more info
     
    toll-like receptor 2 signaling pathway TAS
    Traceable Author Statement
    more info
     
    toll-like receptor 4 signaling pathway TAS
    Traceable Author Statement
    more info
     
    toll-like receptor 5 signaling pathway TAS
    Traceable Author Statement
    more info
     
    toll-like receptor 9 signaling pathway TAS
    Traceable Author Statement
    more info
     
    toll-like receptor TLR1:TLR2 signaling pathway TAS
    Traceable Author Statement
    more info
     
    toll-like receptor TLR6:TLR2 signaling pathway TAS
    Traceable Author Statement
    more info
     
    toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    UBC13-MMS2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    UBC13-UEV1A complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    ubiquitin-conjugating enzyme E2 N
    Names
    bendless-like ubiquitin conjugating enzyme
    bendless-like ubiquitin-conjugating enzyme
    epididymis secretory protein Li 71
    ubiquitin carrier protein N
    ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)
    ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13)
    ubiquitin-protein ligase N
    yeast UBC13 homolog
    NP_003339.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003348.3NP_003339.1  ubiquitin-conjugating enzyme E2 N

      See identical proteins and their annotated locations for NP_003339.1

      Status: REVIEWED

      Source sequence(s)
      AK098233, BC000396, BI459891, CB243041
      Consensus CDS
      CCDS31875.1
      UniProtKB/Swiss-Prot
      P61088
      UniProtKB/TrEMBL
      V9HW41
      Conserved Domains (2) summary
      COG5078
      Location:3150
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:5144
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

      Range
      93408312..93443445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538719.1XP_011537021.1  

    RNA

    1. XR_944706.1 RNA Sequence

    2. XR_944707.1 RNA Sequence

    3. XR_944705.1 RNA Sequence

    4. XR_944704.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      93767035..93800979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)