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    CDCP1 CUB domain containing protein 1 [ Homo sapiens (human) ]

    Gene ID: 64866, updated on 26-Jun-2015
    Official Symbol
    CDCP1provided by HGNC
    Official Full Name
    CUB domain containing protein 1provided by HGNC
    Primary source
    HGNC:HGNC:24357
    See related
    Ensembl:ENSG00000163814; HPRD:16696; MIM:611735; Vega:OTTHUMG00000133090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD318; TRASK; SIMA135
    Summary
    This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
    Orthologs
    See CDCP1 in Epigenomics, MapViewer
    Location:
    3p21.31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (45082274..45146422, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (45123766..45187914, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene exosome component 7 Neighboring gene C-type lectin domain family 3, member B Neighboring gene RNA, U5B small nuclear 3, pseudogene Neighboring gene uncharacterized LOC105377059 Neighboring gene ribosomal protein S24 pseudogene 8 Neighboring gene uncharacterized LOC101928636

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    CUB domain-containing protein 1
    Names
    CUB domain-containing protein 1
    membrane glycoprotein gp140
    subtractive immunization M plus HEp3-associated 135 kDa protein
    transmembrane and associated with src kinases

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022842.4NP_073753.3  CUB domain-containing protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_073753.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AY026461, AY167484, BC021099, CD367582
      Consensus CDS
      CCDS2727.1
      UniProtKB/Swiss-Prot
      Q9H5V8
      Related
      ENSP00000296129, OTTHUMP00000164120, ENST00000296129, OTTHUMT00000256748
      Conserved Domains (1) summary
      cl00049
      Location:225297
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    2. NM_178181.2NP_835488.1  CUB domain-containing protein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_835488.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) transcribes past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AY358779, BC021099
      Consensus CDS
      CCDS46812.1
      UniProtKB/Swiss-Prot
      Q9H5V8
      Related
      ENSP00000399342, OTTHUMP00000209568, ENST00000425231, OTTHUMT00000343581
      Conserved Domains (1) summary
      cl00049
      Location:225297
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

      Range
      45082274..45146422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534024.1XP_011532326.1  

      Conserved Domains (1) summary
      cl00049
      Location:224296
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      45073764..45137892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)