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    MRPL13 mitochondrial ribosomal protein L13 [ Homo sapiens (human) ]

    Gene ID: 28998, updated on 30-Jun-2015
    Official Symbol
    MRPL13provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein L13provided by HGNC
    Primary source
    HGNC:HGNC:14278
    See related
    Ensembl:ENSG00000172172; HPRD:14740; MIM:610200; Vega:OTTHUMG00000165039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L13; L13A; L13mt; RPL13; RPML13
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
    Orthologs
    See MRPL13 in Epigenomics, MapViewer
    Location:
    8q22.1-q22.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (120395844..120445407, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (121408083..121457647, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375730 Neighboring gene uncharacterized LOC105375729 Neighboring gene collagen, type XIV, alpha 1 Neighboring gene MDM2 binding protein Neighboring gene syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) Neighboring gene non-SMC condensin I complex, subunit G pseudogene Neighboring gene uncharacterized LOC101927561

    NHGRI GWAS Catalog

    Description
    Epidemiological and genome-wide association study of gastritis or gastric ulcer in korean populations.
    NHGRI GWA Catalog
    • Mitochondrial translation, organism-specific biosystem (from REACTOME)
      Mitochondrial translation, organism-specific biosystemOf the roughly 1000 human mitochondrial proteins only 13 proteins, all of them hydrophobic inner membrane proteins that are components of the oxidative phosphorylation apparatus, are encoded in the m...
    • Mitochondrial translation elongation, organism-specific biosystem (from REACTOME)
      Mitochondrial translation elongation, organism-specific biosystemTranslation elongation proceeds by cycles of aminoacyl-tRNAs binding, peptide bond formation, and displacement of deacylated tRNAs (reviewed in Christian and Spremulli 2012). In each cycle an aminoac...
    • Mitochondrial translation initiation, organism-specific biosystem (from REACTOME)
      Mitochondrial translation initiation, organism-specific biosystemTranslation initiates with the mitochondrial mRNA binding the 28S subunit:MTIF3 (28S subunit:IF-3Mt, 28S subunit:IF3mt) complex together with MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP) (reviewed in Christian ...
    • Mitochondrial translation termination, organism-specific biosystem (from REACTOME)
      Mitochondrial translation termination, organism-specific biosystemTranslation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al...
    • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
      Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
    • Ribosome, organism-specific biosystem (from KEGG)
      Ribosome, organism-specific biosystem
      Ribosome
    • Ribosome, conserved biosystem (from KEGG)
      Ribosome, conserved biosystem
      Ribosome
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    mitochondrial translation TAS
    Traceable Author Statement
    more info
     
    mitochondrial translational elongation TAS
    Traceable Author Statement
    more info
     
    mitochondrial translational initiation TAS
    Traceable Author Statement
    more info
     
    mitochondrial translational termination TAS
    Traceable Author Statement
    more info
     
    organelle organization TAS
    Traceable Author Statement
    more info
     
    translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    mitochondrial large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    PubMed 
    mitochondrial ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    39S ribosomal protein L13, mitochondrial
    Names
    MRP-L13

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014078.5NP_054797.2  39S ribosomal protein L13, mitochondrial

      See identical proteins and their annotated locations for NP_054797.2

      Status: REVIEWED

      Source sequence(s)
      BC021744, BF243677, CN362173
      Consensus CDS
      CCDS6332.1
      UniProtKB/Swiss-Prot
      Q9BYD1
      Related
      ENSP00000306548, OTTHUMP00000228247, ENST00000306185, OTTHUMT00000381523
      Conserved Domains (1) summary
      cd00392
      Location:18131
      Ribosomal_L13; Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

      Range
      120395844..120445407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006716547.1XP_006716610.1  

      See identical proteins and their annotated locations for XP_006716610.1

      Conserved Domains (1) summary
      cd00392
      Location:2107
      Ribosomal_L13; Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      121448575..121498142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)